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Protein

Apical junction component 1 homolog

Gene

AJM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May be involved in the control of adherens junction integrity.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Apical junction component 1 homologCurated
Gene namesi
Name:AJM1Imported
Synonyms:C9orf172
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000232434.2
HGNCiHGNC:37284 AJM1
neXtProtiNX_C9J069

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000232434
PharmGKBiPA165585544

Polymorphism and mutation databases

BioMutaiC9orf172

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003925441 – 976Apical junction component 1 homologAdd BLAST976

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineBy similarity1
Modified residuei129PhosphoserineBy similarity1
Modified residuei322Omega-N-methylarginineBy similarity1
Modified residuei468PhosphoserineBy similarity1
Modified residuei509PhosphoserineBy similarity1
Modified residuei512PhosphoserineBy similarity1
Modified residuei749Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei749Omega-N-methylarginine; alternateBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiC9J069
PRIDEiC9J069
ProteomicsDBi7898

PTM databases

iPTMnetiC9J069
PhosphoSitePlusiC9J069

Expressioni

Gene expression databases

BgeeiENSG00000232434
GenevisibleiC9J069 HS

Organism-specific databases

HPAiHPA021200

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000412388

Structurei

3D structure databases

ProteinModelPortaliC9J069
SMRiC9J069
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 422Pro-richAdd BLAST355

Phylogenomic databases

eggNOGiENOG410IEQ7 Eukaryota
ENOG4110VJZ LUCA
GeneTreeiENSGT00390000016543
HOGENOMiHOG000231560
InParanoidiC9J069
OMAiNRRFTPT
OrthoDBiEOG091G02B5
PhylomeDBiC9J069
TreeFamiTF323946

Family and domain databases

InterProiView protein in InterPro
IPR038825 Apical_junction
PANTHERiPTHR21517 PTHR21517, 1 hit

Sequencei

Sequence statusi: Complete.

C9J069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRTDPPDLL VSTVYQDIKV ATPGPASKCS PCERSVARPA EPAPFNKRHC
60 70 80 90 100
RSFDFLEALD GPAMETLPEP PPPESAVPRA RTREAEPRRR ARSKSAPRAP
110 120 130 140 150
PGLTPAPASP PVLPRRGREA QRAARAEASP RREPAYPALR ALANELHPIK
160 170 180 190 200
LQPQRGGPGR VAPLCAAAGR CAPPEPPAGP APHVRCRLDI KPDDAVLQHA
210 220 230 240 250
TRGSRSCGPT EAAHWARPAP QFHGLTVPGP RHMALSRTPT PSDSYCADPR
260 270 280 290 300
AFYCDGPLPG PRDYAERRSL PFTTPPGPTQ FFYTEEPQGF RGSFAASPGP
310 320 330 340 350
TFDAYYPRPY PSEELSGPSP RRMGGYYAGE VRTFPIQEPP SRSYYGEAPR
360 370 380 390 400
AYGLPYGPRY VPEEPRAHST ARPFYTEDFG RYRERDVLAR TYPHPRSSPA
410 420 430 440 450
WADWGPRPYR TLQVVPPSDP DPLLASWHGG TGTSPPRLAT DSRHYSRSWD
460 470 480 490 500
NILAPGPRRE DPLGRGRSYE NLLGREVREP RGVSPEGRRP PVVVNLSTSP
510 520 530 540 550
RRYAALSLSE TSLTEKGRAG EGLGRNWYVT PEITITDNDL RATERPSARA
560 570 580 590 600
WELPGGRTRP PPHAAPDGPT SGRQRSLEQL DELITDLVID SRPTAGQASE
610 620 630 640 650
PAADCLGPQL RRLLDSRPAG SGAPALAPPR SPPASAGSAE EPAAPGEAAD
660 670 680 690 700
ASPEPSADED DLMTCSNARC RRTETMFNAC LYFKSCHSCY TYYCSRLCRR
710 720 730 740 750
EDWDAHKARC VYGRVGSVCR HVLQFCRDSG PVHRAFSRIA RVGFLSRGRG
760 770 780 790 800
VLFLGFPSPG SADNFLRFGL EGLLLSPTYL SLRELATHAA PLGSYARELA
810 820 830 840 850
AAGRLYEPAE CFLLSVSVAV GPGTAPPGTP ALPAPAPRSH GPTVRKFAKV
860 870 880 890 900
ALAAGSPARP PPARSREPDM ETLILTPPPG TAGLDQDGEA GRRAREVAFI
910 920 930 940 950
HIQRELRLRG VFLRHEFPRV YEQLCEFVEA NRRFTPTTIY PTDRRTGRPF
960 970
MCMIMAASEP RALDWVASAN LLDDIM
Length:976
Mass (Da):106,650
Last modified:November 3, 2009 - v1
Checksum:i7DB1CCE956BCA47D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355987 Genomic DNA No translation available.
CCDSiCCDS48059.1
RefSeqiNP_001073951.2, NM_001080482.2

Genome annotation databases

EnsembliENST00000436881; ENSP00000412388; ENSG00000232434
GeneIDi389813
KEGGihsa:389813
UCSCiuc011meh.3 human

Similar proteinsi

Entry informationi

Entry nameiAJM1_HUMAN
AccessioniPrimary (citable) accession number: C9J069
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: November 3, 2009
Last modified: June 20, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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