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Protein
Submitted name:

Formin-like protein 2

Gene

FMNL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cytoskeleton organization Source: InterPro
  2. regulation of cell morphogenesis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Formin-like protein 2Imported
Gene namesi
Name:FMNL2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:18267. FMNL2.

Expressioni

Gene expression databases

BgeeiC9IZY8.
ExpressionAtlasiC9IZY8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliC9IZY8.
SMRiC9IZY8. Positions 1-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains FH(formin homology 2) domain.SAAS annotation
Contains FH2 (formin homology 2) domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118986.
HOGENOMiHOG000168240.

Family and domain databases

InterProiIPR014767. Diaphanous_autoregulatory.
IPR015425. FH2_Formin.
IPR027656. FMNL2.
[Graphical view]
PANTHERiPTHR23213:SF180. PTHR23213:SF180. 1 hit.
PfamiPF02181. FH2. 1 hit.
[Graphical view]
SMARTiSM00498. FH2. 1 hit.
[Graphical view]
PROSITEiPS51231. DAD. 1 hit.
PS51444. FH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9IZY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVFNWVALK PNQINGTVFN EIDDERILED LNVDEFEEIF KTKAQGPAID
60 70 80 90 100
LSSSKQKIPQ KGSNKVTLLE ANRAKNLAIT LRKAGKTADE ICKAIHVFDL
110 120 130 140 150
KTLPVDFVEC LMRFLPTENE VKVLRLYERE RKPLENLSDE DRFMMQFSKI
160 170 180 190 200
ERLMQKMTIM AFIGNFAESI QMLTPQLHAI IAASVSIKSS QKLKKILEII
210 220 230 240 250
LALGNYMNSS KRGAVYGFKL QSLDLLLDTK STDRKQTLLH YISNVVKEKY
260 270 280 290 300
HQVSLFYNEL HYVEKAAAVS LENVLLDVKE LQRGMDLTKR EYTMHDHNTL
310 320 330 340 350
LKEFILNNEG KLKKLQDDAK IAQDAFDDVV KYFGENPKTT PPSVFFPVFV
360 370 380 390 400
RFVKAYKQAE EENELRKKQE QALMEKLLEQ EALMEQQDPK SPSHKSKRQQ
410 420 430 440 450
QELIAELRRR QVKDNRHVYE GKDGAIEDII TVLKTVPFTA RTAKRGSRFF
460
CEPVLTEEYH Y
Length:461
Mass (Da):53,384
Last modified:November 3, 2009 - v1
Checksum:i2585A66FF0D55DD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012066 Genomic DNA. No translation available.
AC012443 Genomic DNA. No translation available.
AC093794 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000475377; ENSP00000418959; ENSG00000157827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012066 Genomic DNA. No translation available.
AC012443 Genomic DNA. No translation available.
AC093794 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliC9IZY8.
SMRiC9IZY8. Positions 1-396.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000475377; ENSP00000418959; ENSG00000157827.

Organism-specific databases

HGNCiHGNC:18267. FMNL2.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118986.
HOGENOMiHOG000168240.

Miscellaneous databases

ChiTaRSiFMNL2. human.
NextBioi35484386.

Gene expression databases

BgeeiC9IZY8.
ExpressionAtlasiC9IZY8. baseline and differential.

Family and domain databases

InterProiIPR014767. Diaphanous_autoregulatory.
IPR015425. FH2_Formin.
IPR027656. FMNL2.
[Graphical view]
PANTHERiPTHR23213:SF180. PTHR23213:SF180. 1 hit.
PfamiPF02181. FH2. 1 hit.
[Graphical view]
SMARTiSM00498. FH2. 1 hit.
[Graphical view]
PROSITEiPS51231. DAD. 1 hit.
PS51444. FH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiC9IZY8_HUMAN
AccessioniPrimary (citable) accession number: C9IZY8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: March 4, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationMaxQB annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.