C9IZW4 (C9IZW4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Breast cancer type 1 susceptibility protein Ensembl ENSP00000418986

Gene names

Name:

BRCA1 Ensembl ENSP00000418986

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000418986

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	177 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000418986

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: InterPro DNA replication Inferred from electronic annotation. Source: Compara centrosome cycle Inferred from electronic annotation. Source: Compara chordate embryonic development Inferred from electronic annotation. Source: Compara dosage compensation by inactivation of X chromosome Inferred from electronic annotation. Source: Compara negative regulation of histone H3-K4 methylation Inferred from electronic annotation. Source: Compara negative regulation of histone H3-K9 methylation Inferred from electronic annotation. Source: Compara negative regulation of histone acetylation Inferred from electronic annotation. Source: Compara positive regulation of histone H3-K4 methylation Inferred from electronic annotation. Source: Compara positive regulation of histone H3-K9 acetylation Inferred from electronic annotation. Source: Compara positive regulation of histone H3-K9 methylation Inferred from electronic annotation. Source: Compara positive regulation of histone H4-K16 acetylation Inferred from electronic annotation. Source: Compara positive regulation of histone H4-K20 methylation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of DNA methylation Inferred from electronic annotation. Source: Compara regulation of gene expression by genetic imprinting Inferred from electronic annotation. Source: Compara
Cellular_component	condensed nuclear chromosome Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara
Molecular_function	damaged DNA binding Inferred from electronic annotation. Source: Compara transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	177	1	Ensembl ENSP00000418986

Sequences

	Sequence		Length	Mass (Da)
	C9IZW4 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: 3FFE5470C6CC4831	FASTA	177	20,037
	10 20 30 40 50 60 MNVEKAEFCN KSKQPGLARS QHNRWAGSKE TCNDRRTPST EKKVDLNADP LCERKEWNKQ 70 80 90 100 110 120 KLPCSENPRD TEDVPWITLN SSIQKVNEWF SRSDELLGSD DSHDGESESN AKVADVLDVL 130 140 150 160 170 NEVDEYSGSS EKIDLLASDP HEALICKSER VHSKSVESNI EDKIFGKTYR KKASLPN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC060780 Genomic DNA. No translation available. AC135721 Genomic DNA. No translation available.
IPI	IPI00945613.
3D structure databases
ProteinModelPortal	C9IZW4.
ModBase	Search...
Protein-protein interaction databases
STRING	C9IZW4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000497488; ENSP00000418986; ENSG00000012048.
Organism-specific databases
HGNC	HGNC:1100. BRCA1.
GenAtlas	Search...
Gene expression databases
ArrayExpress	C9IZW4.
Bgee	C9IZW4.
Family and domain databases
InterPro	IPR011364. BRCA1. IPR025994. BRCA1_serine_dom. [Graphical view]
PANTHER	PTHR13763. PTHR13763. 1 hit.
Pfam	PF12820. BRCT_assoc. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BRCA1. human.
NextBio	35484374.

Entry information

Entry name

C9IZW4_HUMAN

Accession

Primary (citable) accession number: C9IZW4

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	April 3, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.