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Protein
Submitted name:

HCG2022551, isoform CRA_j

Gene

KALRN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
HCG2022551, isoform CRA_jImported
Submitted name:
KalirinImported
Gene namesi
Name:KALRNImported
ORF Names:hCG_2022551Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4814. KALRN.

PTM / Processingi

Proteomic databases

PeptideAtlasiC9IZQ6.

Expressioni

Gene expression databases

BgeeiENSG00000160145.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000240874.

Structurei

3D structure databases

SMRiC9IZQ6. Positions 1270-1573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 180146CRAL-TRIOInterPro annotationAdd
BLAST
Domaini1272 – 1447176DH (DBL-homology)InterPro annotationAdd
BLAST
Domaini1459 – 1571113PHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili919 – 94628Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4240. Eukaryota.
ENOG410XPCA. LUCA.
GeneTreeiENSGT00760000119030.
HOGENOMiHOG000044462.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR028569. Kalirin.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR22826:SF49. PTHR22826:SF49. 2 hits.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00516. SEC14. 1 hit.
SM00150. SPEC. 7 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9IZQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDRFWDQWY LWYLRLLRLL DRGSFRNDGL KASDVLPILK EKVAFVSGGR
60 70 80 90 100
DKRGGPILTF PARSNHDRIR QEDLRKLVTY LASVPSEDVC KRGFTVIIDM
110 120 130 140 150
RGSKWDLIKP LLKTLQEAFP AEIHVALIIK PDNFWQKQKT NFGSSKFIFE
160 170 180 190 200
TSMVSVEGLT KLVDPSQLTE EFDGSLDYNH EEWIELRLSL EEFFNSAVHL
210 220 230 240 250
LSRLEDLQEM LARKEFPVDV EGSRRLIDEH TQLKKKVLKA PVEELDREGQ
260 270 280 290 300
RLLQCIRCSD GFSGRNCIPG SADFQSLVPK ITSLLDKLHS TRQHLHQMWH
310 320 330 340 350
VRKLKLDQCF QLRLFEQDAE KMFDWISHNK ELFLQSHTEI GVSYQYALDL
360 370 380 390 400
QTQHNHFAMN SMNAYVNINR IMSVASRLSE AGHYASQQIK QISTQLDQEW
410 420 430 440 450
KSFAAALDER STILAMSAVF HQKAEQFLSG VDAWCKMCSE GGLPSEMQDL
460 470 480 490 500
ELAIHHHQTL YEQVTQAYTE VSQDGKALLD VLQRPLSPGN SESLTATANY
510 520 530 540 550
SKAVHQVLDV VHEVLHHQRR LESIWQHRKV RLHQRLQLCV FQQDVQQVLD
560 570 580 590 600
WIENHGEAFL SKHTGVGKSL HRARALQKRH DDFEEVAQNT YTNADKLLEA
610 620 630 640 650
AEQLAQTGEC DPEEIYKAAR HLEVRIQDFV RRVEQRKLLL DMSVSFHTHT
660 670 680 690 700
KELWTWMEDL QKEMLEDVCA DSVDAVQELI KQFQQQQTAT LDATLNVIKE
710 720 730 740 750
GEDLIQQLRS APPSLGEPSE ARDSAVSNNK TPHSSSISHI ESVLQQLDDA
760 770 780 790 800
QVQMEELFHE RKIKLDIFLQ LRIFEQYTIE VTAELDAWNE DLLRQMNDFN
810 820 830 840 850
TEDLTLAEQR LQRHTERKLA MNNMTFEVIQ QGQDLHQYIT EVQASGIELI
860 870 880 890 900
CEKDIDLAAQ VQELLEFLHE KQHELELNAE QTHKRLEQCL QLRHLQAEVK
910 920 930 940 950
QVLGWIRNGE SMLNASLVNA SSLSEAEQLQ REHEQFQLAI EKTHQSALQV
960 970 980 990 1000
QQKAEVLLQA GHYDADAIRE CAEKVALHWQ QLMLKMEDRL KLVNASVAFY
1010 1020 1030 1040 1050
KTSEQVCSVL ESLEQEYRRD EDWCGGRDKL GPAAEIDHVI PLISKHLEQK
1060 1070 1080 1090 1100
EAFLKACTLA RRNAEVFLKY IHRNNVSMPS VASHTRGPEQ QVKAILSELL
1110 1120 1130 1140 1150
QRENRVLHFW TLKKRRLDQC QQYVVFERSA KQALDWIQET GEFYLSTHTS
1160 1170 1180 1190 1200
TGETTEETQE LLKEYGEFRV PAKQTKEKVK LLIQLADSFV EKGHIHATEI
1210 1220 1230 1240 1250
RKWVTTVDKH YRDFSLRMGK YRYSLEKALG VNTEDNKDLE LDIIPASLSD
1260 1270 1280 1290 1300
REVKLRDANH EVNEEKRKSA RKKEFIMAEL LQTEKAYVRD LHECLETYLW
1310 1320 1330 1340 1350
EMTSGVEEIP PGILNKEHII FGNIQEIYDF HNNIFLKELE KYEQLPEDVG
1360 1370 1380 1390 1400
HCFVTWADKF QMYVTYCKNK PDSNQLILEH AGTFFDEIQQ RHGLANSISS
1410 1420 1430 1440 1450
YLIKPVQRIT KYQLLLKELL TCCEEGKGEL KDGLEVMLSV PKKANDAMHV
1460 1470 1480 1490 1500
SMLEGFDENL DVQGELILQD AFQVWDPKSL IRKGRERHLF LFEISLVFSK
1510 1520 1530 1540 1550
EIKDSSGHTK YVYKNKLLTS ELGVTEHVEG DPCKFALWSG RTPSSDNKTV
1560 1570 1580 1590 1600
LKASNIETKQ EWIKNIREVI QERIIHLKGA LKEPLQLPKT PAKQRNNSKR
1610 1620 1630 1640 1650
DGVEDIDSQG DGSSQPDTIS IASRTSQNTV DSDKDGNLVP RWHLGPGDPF

STYV
Length:1,654
Mass (Da):191,244
Last modified:November 3, 2009 - v1
Checksum:i909B73D9BEE7EA36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022336 Genomic DNA. No translation available.
AC069233 Genomic DNA. No translation available.
AC080008 Genomic DNA. No translation available.
AC112129 Genomic DNA. No translation available.
AC117401 Genomic DNA. No translation available.
KF457679 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79423.1.
RefSeqiNP_001309918.1. NM_001322989.1.
UniGeneiHs.13281.
Hs.8004.

Genome annotation databases

EnsembliENST00000460856; ENSP00000418611; ENSG00000160145.
GeneIDi8997.
UCSCiuc010hrv.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022336 Genomic DNA. No translation available.
AC069233 Genomic DNA. No translation available.
AC080008 Genomic DNA. No translation available.
AC112129 Genomic DNA. No translation available.
AC117401 Genomic DNA. No translation available.
KF457679 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79423.1.
RefSeqiNP_001309918.1. NM_001322989.1.
UniGeneiHs.13281.
Hs.8004.

3D structure databases

SMRiC9IZQ6. Positions 1270-1573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000240874.

Proteomic databases

PeptideAtlasiC9IZQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000460856; ENSP00000418611; ENSG00000160145.
GeneIDi8997.
UCSCiuc010hrv.2. human.

Organism-specific databases

CTDi8997.
HGNCiHGNC:4814. KALRN.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4240. Eukaryota.
ENOG410XPCA. LUCA.
GeneTreeiENSGT00760000119030.
HOGENOMiHOG000044462.

Miscellaneous databases

ChiTaRSiKALRN. human.
GenomeRNAii8997.

Gene expression databases

BgeeiENSG00000160145.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR028569. Kalirin.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR22826:SF49. PTHR22826:SF49. 2 hits.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00516. SEC14. 1 hit.
SM00150. SPEC. 7 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC9IZQ6_HUMAN
AccessioniPrimary (citable) accession number: C9IZQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.