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Protein
Submitted name:

HCG2022551, isoform CRA_j

Gene

KALRN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
HCG2022551, isoform CRA_jImported
Submitted name:
KalirinImported
Gene namesi
Name:KALRNImported
ORF Names:hCG_2022551Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000160145.15
HGNCiHGNC:4814 KALRN

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160145

Expressioni

Gene expression databases

BgeeiENSG00000160145

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 180CRAL-TRIOInterPro annotationAdd BLAST146
Domaini1272 – 1447DHInterPro annotationAdd BLAST176
Domaini1459 – 1571PHInterPro annotationAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili740 – 760Sequence analysisAdd BLAST21
Coiled coili858 – 878Sequence analysisAdd BLAST21
Coiled coili919 – 946Sequence analysisAdd BLAST28
Coiled coili1248 – 1268Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4240 Eukaryota
ENOG410XPCA LUCA
GeneTreeiENSGT00760000119030
HOGENOMiHOG000044462

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd00170 SEC14, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR028569 Kalirin
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PANTHERiPTHR22826:SF49 PTHR22826:SF49, 7 hits
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF00435 Spectrin, 4 hits
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00516 SEC14, 1 hit
SM00150 SPEC, 7 hits
SUPFAMiSSF48065 SSF48065, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

C9IZQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDRFWDQWY LWYLRLLRLL DRGSFRNDGL KASDVLPILK EKVAFVSGGR
60 70 80 90 100
DKRGGPILTF PARSNHDRIR QEDLRKLVTY LASVPSEDVC KRGFTVIIDM
110 120 130 140 150
RGSKWDLIKP LLKTLQEAFP AEIHVALIIK PDNFWQKQKT NFGSSKFIFE
160 170 180 190 200
TSMVSVEGLT KLVDPSQLTE EFDGSLDYNH EEWIELRLSL EEFFNSAVHL
210 220 230 240 250
LSRLEDLQEM LARKEFPVDV EGSRRLIDEH TQLKKKVLKA PVEELDREGQ
260 270 280 290 300
RLLQCIRCSD GFSGRNCIPG SADFQSLVPK ITSLLDKLHS TRQHLHQMWH
310 320 330 340 350
VRKLKLDQCF QLRLFEQDAE KMFDWISHNK ELFLQSHTEI GVSYQYALDL
360 370 380 390 400
QTQHNHFAMN SMNAYVNINR IMSVASRLSE AGHYASQQIK QISTQLDQEW
410 420 430 440 450
KSFAAALDER STILAMSAVF HQKAEQFLSG VDAWCKMCSE GGLPSEMQDL
460 470 480 490 500
ELAIHHHQTL YEQVTQAYTE VSQDGKALLD VLQRPLSPGN SESLTATANY
510 520 530 540 550
SKAVHQVLDV VHEVLHHQRR LESIWQHRKV RLHQRLQLCV FQQDVQQVLD
560 570 580 590 600
WIENHGEAFL SKHTGVGKSL HRARALQKRH DDFEEVAQNT YTNADKLLEA
610 620 630 640 650
AEQLAQTGEC DPEEIYKAAR HLEVRIQDFV RRVEQRKLLL DMSVSFHTHT
660 670 680 690 700
KELWTWMEDL QKEMLEDVCA DSVDAVQELI KQFQQQQTAT LDATLNVIKE
710 720 730 740 750
GEDLIQQLRS APPSLGEPSE ARDSAVSNNK TPHSSSISHI ESVLQQLDDA
760 770 780 790 800
QVQMEELFHE RKIKLDIFLQ LRIFEQYTIE VTAELDAWNE DLLRQMNDFN
810 820 830 840 850
TEDLTLAEQR LQRHTERKLA MNNMTFEVIQ QGQDLHQYIT EVQASGIELI
860 870 880 890 900
CEKDIDLAAQ VQELLEFLHE KQHELELNAE QTHKRLEQCL QLRHLQAEVK
910 920 930 940 950
QVLGWIRNGE SMLNASLVNA SSLSEAEQLQ REHEQFQLAI EKTHQSALQV
960 970 980 990 1000
QQKAEVLLQA GHYDADAIRE CAEKVALHWQ QLMLKMEDRL KLVNASVAFY
1010 1020 1030 1040 1050
KTSEQVCSVL ESLEQEYRRD EDWCGGRDKL GPAAEIDHVI PLISKHLEQK
1060 1070 1080 1090 1100
EAFLKACTLA RRNAEVFLKY IHRNNVSMPS VASHTRGPEQ QVKAILSELL
1110 1120 1130 1140 1150
QRENRVLHFW TLKKRRLDQC QQYVVFERSA KQALDWIQET GEFYLSTHTS
1160 1170 1180 1190 1200
TGETTEETQE LLKEYGEFRV PAKQTKEKVK LLIQLADSFV EKGHIHATEI
1210 1220 1230 1240 1250
RKWVTTVDKH YRDFSLRMGK YRYSLEKALG VNTEDNKDLE LDIIPASLSD
1260 1270 1280 1290 1300
REVKLRDANH EVNEEKRKSA RKKEFIMAEL LQTEKAYVRD LHECLETYLW
1310 1320 1330 1340 1350
EMTSGVEEIP PGILNKEHII FGNIQEIYDF HNNIFLKELE KYEQLPEDVG
1360 1370 1380 1390 1400
HCFVTWADKF QMYVTYCKNK PDSNQLILEH AGTFFDEIQQ RHGLANSISS
1410 1420 1430 1440 1450
YLIKPVQRIT KYQLLLKELL TCCEEGKGEL KDGLEVMLSV PKKANDAMHV
1460 1470 1480 1490 1500
SMLEGFDENL DVQGELILQD AFQVWDPKSL IRKGRERHLF LFEISLVFSK
1510 1520 1530 1540 1550
EIKDSSGHTK YVYKNKLLTS ELGVTEHVEG DPCKFALWSG RTPSSDNKTV
1560 1570 1580 1590 1600
LKASNIETKQ EWIKNIREVI QERIIHLKGA LKEPLQLPKT PAKQRNNSKR
1610 1620 1630 1640 1650
DGVEDIDSQG DGSSQPDTIS IASRTSQNTV DSDKDGNLVP RWHLGPGDPF

STYV
Length:1,654
Mass (Da):191,244
Last modified:November 3, 2009 - v1
Checksum:i909B73D9BEE7EA36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022336 Genomic DNA No translation available.
AC069233 Genomic DNA No translation available.
AC080008 Genomic DNA No translation available.
AC112129 Genomic DNA No translation available.
AC117401 Genomic DNA No translation available.
KF457679 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79423.1
RefSeqiNP_001309918.1, NM_001322989.1
UniGeneiHs.13281
Hs.8004

Genome annotation databases

EnsembliENST00000460856; ENSP00000418611; ENSG00000160145
GeneIDi8997
UCSCiuc010hrv.2 human

Similar proteinsi

Entry informationi

Entry nameiC9IZQ6_HUMAN
AccessioniPrimary (citable) accession number: C9IZQ6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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