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C8ZCV7 (SDC25_YEAS8) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Guanine nucleotide exchange factor SDC25
Gene names
Name:SDC25
Synonyms:SCD25
ORF Names:EC1118_1L10_0518g
OrganismSaccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's yeast) [Complete proteome]
Taxonomic identifier643680 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length1252 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Promotes the exchange of Ras-bound GDP by GTP By similarity.

Miscellaneous

Suppresses the CDC25-5 mutation in yeast (restores cAMP level) and has similar functions as CDC25.

Sequence similarities

Contains 1 N-terminal Ras-GEF domain.

Contains 1 Ras-GEF domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12521252Guanine nucleotide exchange factor SDC25
PRO_0000393440

Regions

Domain26 – 9772SH3
Domain782 – 914133N-terminal Ras-GEF
Domain952 – 1199248Ras-GEF

Sequences

Sequence LengthMass (Da)Tools
C8ZCV7 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: C58AD11F9870C560

FASTA1,252145,132
        10         20         30         40         50         60 
MSRTASYAGM TTPVKDKEGH GIPCLQPIDV VECTYQYFTK SQNKLSLRVG DLIYVLTKGS 

        70         80         90        100        110        120 
NGWWDGVLIR HSANNNNNSL ILDRGWFPPS FTRSILNELH GVPEIGNELE IFQAGLNLKL 

       130        140        150        160        170        180 
ELSSNPVILS LEDFLDCCRD IEFKEQLAWS PIPVHERKGC CELLYYNQDL DVYCRTLPYL 

       190        200        210        220        230        240 
PQNQVETVND YSSFPAISKI AGKKMPITSS PDLFYLNDCD VVYWYDLTRL VCHYVNLTER 

       250        260        270        280        290        300 
DLLANEREKF LTSLDLLTAQ ITYVYMLFRN LRLVEDSFKK TLKKLIYTLS RFSINANIWF 

       310        320        330        340        350        360 
HSTPFEEREA IASQKDPERR SPLLQSILGT FQKFHFLLRL LHFLSNPNEL TILPQLTPRF 

       370        380        390        400        410        420 
FKDSFNTISW NNPFLRKHLN QHMSHDLPRQ MIKAVAGASG IVAENNDEIP ASKQGTSCSS 

       430        440        450        460        470        480 
ETSHHSPSAP FQRRRRGTIF SNVPGSSDES DTIWSKRKKP YPLNEETLSL VRARKEQLDA 

       490        500        510        520        530        540 
KLKQMIKSAN EYLSNTANFS KMLNSEMNFK TYEEVSGTIP IIDILENLDL TIYLNLRELG 

       550        560        570        580        590        600 
DENRVFDEDV AIDDEDKEFL KHSLSSLSYI LSDYFNMKQY FHDVVVKFII VAQHLTLEDP 

       610        620        630        640        650        660 
FVFSPMQNDL PTGYYEPMKP SSLNLDNAKD KKNGSQNTDI QEEEDEYEPD PDSLILFHNL 

       670        680        690        700        710        720 
INQDSDFNDL KFFNLAHVFK KSCDDYFDVL KLSIEFVNRL ILERENLLNY AARMMKNNIT 

       730        740        750        760        770        780 
ELLLRGEEGY GSYDGGETAE KSDTNAVYAD SDTKDNDEWR DSQVKLPRYL QREYDSELIW 

       790        800        810        820        830        840 
GSNNRIKGGS KHALISYLTD NEKKDLFFNI TFLITFRSIF TTTEFLSYLI SQYNLDPPED 

       850        860        870        880        890        900 
LCFEEYNEWV TKKLIPVKCR VVEIMTTFFK QYWFPGYDEP DLATLNLDYF AQVAIKENIT 

       910        920        930        940        950        960 
GSVELLKEVN QKFKHGNMQE ATAPMKTLDQ QICQEHYWGT LYSTTESILA VDPVLFATQL 

       970        980        990       1000       1010       1020 
TILEHEIYCE ITIFDCLQKI WKNKYTKSYG ASPGLNEFIS FANKLTNFIS YSIVKEADKS 

      1030       1040       1050       1060       1070       1080 
KRAKLLSHFI FIAEYCRKFN NFSSMTAIIS ALYSSPIYRL EKTWQAVIPQ TRDLLQSLDK 

      1090       1100       1110       1120       1130       1140 
LMDPKKNFID YRSELKSLHS APCVPFFGVY LSDLTFTDSG NPDYLVLEHG LKGVHDEKKY 

      1150       1160       1170       1180       1190       1200 
INFNKRSRLV DILQEIIYFK KTHYDFTKDR TVIECISNSL ENIPHIEKQY QLSLIIEPKP 

      1210       1220       1230       1240       1250 
RKKVVPNSNS NNKSQEKSRD DQTDEGKTST KKDRFSKFQL HKTKKKAPKV SK 

« Hide

References

[1]"Eukaryote-to-eukaryote gene transfer events revealed by the genome sequence of the wine yeast Saccharomyces cerevisiae EC1118."
Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B., Legras J.-L., Wincker P., Casaregola S., Dequin S.
Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Lalvin EC1118 / Prise de mousse.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FN393078 Genomic DNA. Translation: CAY81223.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG78WM2F.

Family and domain databases

Gene3D1.10.840.10. 1 hit.
InterProIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDC25_YEAS8
AccessionPrimary (citable) accession number: C8ZCV7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: November 3, 2009
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families