ID   C8XK68_NAKMY            Unreviewed;       524 AA.
AC   C8XK68;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Transcriptional regulator, LuxR family {ECO:0000313|EMBL:ACV76751.1};
GN   OrderedLocusNames=Namu_0321 {ECO:0000313|EMBL:ACV76751.1};
OS   Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / CIP 104796 / JCM
OS   9543 / NBRC 105858 / Y-104) (Microsphaera multipartita).
OC   Bacteria; Actinomycetota; Actinomycetes; Nakamurellales; Nakamurellaceae;
OC   Nakamurella.
OX   NCBI_TaxID=479431 {ECO:0000313|EMBL:ACV76751.1, ECO:0000313|Proteomes:UP000002218};
RN   [1] {ECO:0000313|Proteomes:UP000002218}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700099 / DSM 44233 / CIP 104796 / JCM 9543 / NBRC 105858 /
RC   Y-104 {ECO:0000313|Proteomes:UP000002218};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Ovchinnikova G., Sims D., Meincke L., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA   Woyke T., Wu D., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Nakamurella multipartita DSM 44233.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACV76751.1, ECO:0000313|Proteomes:UP000002218}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700099 / DSM 44233 / CIP 104796 / JCM 9543 / NBRC 105858 /
RC   Y-104 {ECO:0000313|Proteomes:UP000002218};
RX   PubMed=21304699;
RA   Tice H., Mayilraj S., Sims D., Lapidus A., Nolan M., Lucas S.,
RA   Glavina Del Rio T., Copeland A., Cheng J.F., Meincke L., Bruce D.,
RA   Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA   Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Detter J.C., Brettin T., Rohde M., Goker M., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Chen F.;
RT   "Complete genome sequence of Nakamurella multipartita type strain (Y-
RT   104).";
RL   Stand. Genomic Sci. 2:168-175(2010).
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DR   EMBL; CP001737; ACV76751.1; -; Genomic_DNA.
DR   RefSeq; WP_012814226.1; NC_013235.1.
DR   AlphaFoldDB; C8XK68; -.
DR   STRING; 479431.Namu_0321; -.
DR   KEGG; nml:Namu_0321; -.
DR   eggNOG; COG2197; Bacteria.
DR   eggNOG; COG2206; Bacteria.
DR   HOGENOM; CLU_040286_1_0_11; -.
DR   InParanoid; C8XK68; -.
DR   Proteomes; UP000002218; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00077; HDc; 2.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF13487; HD_5; 2.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 2.
DR   PROSITE; PS51832; HD_GYP; 2.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002218}.
FT   DOMAIN          28..243
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   DOMAIN          259..454
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   DOMAIN          450..515
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50043"
SQ   SEQUENCE   524 AA;  55668 MW;  2393C11ADE05CF72 CRC64;
     MLAADPAPAR PRRAEVLAAL SLALDLGLGQ PMEHMLRAAV IATRMADRIG MDATERGVVY
     YAELVSWIGC QADSPELSAL FADEIAFRAG TFPIDLRGRN RARFLLGQAG HGRPPLAGGR
     ARLRLLADGR RRMHELLESH YASAGALADR LGLGAGVRDA IHHTFERWDG TGLPRGIGGP
     AIPIAMRIVH VADVIEVQLR AAGPEAAVQL ARRRSGTQFD PQVVAVLTGA ADEIFAGLDQ
     QDVWPLALSQ APDPRLALSD PEVDALLIAI GDFVDVKSPR RQGHSRRVGA LAARAGQSRG
     LPETTVHALR RAGWVHDLGR LGVPGALWDR SGPLSSADRE RIRLYPYFTQ RILGRVGGLA
     EVAEIAGAHR ERLDGSGFPR GVDGSSLSVP ARLLAAAARL QSLTEERLDR PAVGLAQAVR
     TLEREAAAGA LDAQAVAAVA DAAGQPQPRR RARATGLTAR EEQVLALAAV GRSSRQIAAE
     LTISEKTARN HLEHIYTKTG VSNRAGASLF AVQHGIVRAG PPTG
//