C8XHN8 (C8XHN8_NAKMY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GTPase Der RuleBase RU004481 HAMAP-Rule MF_00195

Alternative name(s):
GTP-binding protein EngA HAMAP-Rule MF_00195

Gene names

Name:	der HAMAP-Rule MF_00195
Ordered Locus Names:	Namu_4051

Organism

Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / JCM 9543 / Y-104) (Microsphaera multipartita) [Complete proteome] [HAMAP] EMBL ACV80341.1

Taxonomic identifier

479431 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Nakamurellaceae › Nakamurella › Nakamurella multipartita

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. RuleBase RU004481 HAMAP-Rule MF_00195 SAAS SAAS016484
Subunit structure	Associates with the 50S ribosomal subunit By similarity. HAMAP-Rule MF_00195 SAAS SAAS016484
Sequence similarities	Belongs to the Era/MnmE GTP-binding protein family. Der subfamily. RuleBase RU004481 HAMAP-Rule MF_00195 Contains 1 KH-like domain. HAMAP-Rule MF_00195 SAAS SAAS016484 Contains 2 G (guanine nucleotide-binding) domains. HAMAP-Rule MF_00195 SAAS SAAS016484

Ontologies

Keywords
Biological process	Ribosome biogenesis HAMAP-Rule MF_00195 SAAS SAAS016484
Domain	Repeat RuleBase RU004481 HAMAP-Rule MF_00195 SAAS SAAS016484
Ligand	GTP-binding HAMAP-Rule MF_00195 SAAS SAAS016484 RuleBase RU003312 Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ribosome biogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	GTP binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Domain	49 – 163	115	G 1 By similarity HAMAP-Rule MF_00195
	Domain	222 – 340	119	G 2 By similarity HAMAP-Rule MF_00195
	Domain	394 – 478	85	KH-like By similarity HAMAP-Rule MF_00195
	Nucleotide binding	53 – 60	8	GTP 1 By similarity HAMAP-Rule MF_00195
	Nucleotide binding	100 – 104	5	GTP 1 By similarity HAMAP-Rule MF_00195
	Nucleotide binding	162 – 165	4	GTP 1 By similarity HAMAP-Rule MF_00195
	Nucleotide binding	227 – 234	8	GTP 2 By similarity HAMAP-Rule MF_00195
	Nucleotide binding	274 – 278	5	GTP 2 By similarity HAMAP-Rule MF_00195
	Nucleotide binding	339 – 342	4	GTP 2 By similarity HAMAP-Rule MF_00195

Sequences

	Sequence		Length	Mass (Da)
	C8XHN8 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: 4DBB1FCA785D51E0	FASTA	483	52,021
	10 20 30 40 50 60 MSDEYAGPAI EAGDGVADGT WADESEFTGW EDGSAEDDGF DQGGPAPTLA VVGRPNVGKS 70 80 90 100 110 120 TLVNRLIGRR EAVVQDVPGV TRDRVSHDAL WRGRRFTVVD TGGWDPMASG LQAEVTAQAE 130 140 150 160 170 180 RAMQTSDAVL VVVDASVGAT ETEDAIAKVL RRSKRPVILA VNKVDDERAE ADAAALWSLG 190 200 210 220 230 240 LGEPIAVSGL HGRGSGDLLD AVLEALPTAP EEFVGSGGGP RRVALIGRPN VGKSSLLNKL 250 260 270 280 290 300 TGESRSVVHA VAGTTVDPVD SLVEIDGQLW RFVDTAGLRR RVNQAKGMEY YASLRTQTAL 310 320 330 340 350 360 ESAEVAIALI DSSTPITEQD QRVISMVIDS GRALVIALNK ADLVDADRRA EVEDEVLRDL 370 380 390 400 410 420 ARVAWAQRIN ISAQSGRGVH RLAPAMTRAL ESWDRRIPTG RLNSWLGELI AATPPPVRGG 430 440 450 460 470 480 KQPRVLFATQ ASNRPPTFVL FTTGFLEAGY RRFIERRLRE DFEFTGSPVR VNVRVREKRG AKK

References

[1]

"The complete genome of Nakamurella multipartita DSM 44233." US DOE Joint Genome Institute (JGI-PGF) Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Sims D., Meincke L., Brettin T., Detter J.C., Han C. , Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Klenk H.-P., Eisen J.A. Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700099 / DSM 44233 / JCM 9543 / Y-104.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001737 Genomic DNA. Translation: ACV80341.1.
RefSeq	YP_003203330.1. NC_013235.1.
3D structure databases
ProteinModelPortal	C8XHN8.
ModBase	Search...
Protein-protein interaction databases
STRING	479431.Namu_4051.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACV80341; ACV80341; Namu_4051.
GeneID	8449671.
KEGG	nml:Namu_4051.
PATRIC	22665766. VBINakMul62011_4102.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1160.
HOGENOM	HOG000242861.
KO	K03977.
OMA	IEWISSS.
Enzyme and pathway databases
BioCyc	NMUL479431:GHQL-4079-MONOMER.
Family and domain databases
Gene3D	3.30.300.20. 1 hit.
HAMAP	MF_00195. GTPase_Der.
InterPro	IPR003593. AAA+_ATPase. IPR016484. GTP-bd_EngA. IPR006073. GTP_binding_domain. IPR015946. KH_dom-like_a/b. IPR005225. Small_GTP-bd_dom. [Graphical view]
PANTHER	PTHR11649:SF5. PTHR11649:SF5. 1 hit.
Pfam	PF01926. MMR_HSR1. 2 hits. [Graphical view]
PIRSF	PIRSF006485. GTP-binding_EngA. 1 hit.
PRINTS	PR00326. GTP1OBG.
SMART	SM00382. AAA. 2 hits. [Graphical view]
TIGRFAMs	TIGR03594. GTPase_EngA. 1 hit. TIGR00231. small_GTP. 2 hits.
ProtoNet	Search...

Entry information

Entry name

C8XHN8_NAKMY

Accession

Primary (citable) accession number: C8XHN8

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)