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C8X828 (C8X828_NAKMY) Unreviewed, UniProtKB/TrEMBL

Last modified May 14, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential EMBL ACV77004.1
Chain20 – 417398 Potential EMBL ACV77004.1
PRO_5000521841

Sequences

Sequence LengthMass (Da)Tools
C8X828 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: A52B22440F21C3AB

FASTA41744,580
        10         20         30         40         50         60 
MSSLTTGAIT GSITRAQAQD LDRTDPLAGF RDRYLPATDD VVAYLDGNSL GRPLAAIADS 

        70         80         90        100        110        120 
WQRFTHEQWA GRLIRGWSEG WMDLPELVGD ELAAAALGAA PGQTIIADST TVNFYKAMRA 

       130        140        150        160        170        180 
ALNLRPGRTK IILDRDNFPT NRYVAESLAR DLGLELVWLE PPIDGGVTPE AVAAVIDERT 

       190        200        210        220        230        240 
AVVTLSHIAY QSAFLADAPA ITEVAHRAGA LVVWDLCHSV GSTEIELDAW DVDFAVGCTY 

       250        260        270        280        290        300 
KFVGAGPGAP ALLYANARHH AGLDQPIWGW LGRQDSFEME QGYRPAAGIR SMMSGTPPLL 

       310        320        330        340        350        360 
GLLAVREGAA VIAEAGIAAI RAKAVALTEM VTAIAEDTLV PQGFTVMSPC DPARRGGHVS 

       370        380        390        400        410 
IARPDARELS QRLTEAGVLI DFRAPQAIRI GLSPLPASFT EVWDAMEVIR TLSAPAH 

« Hide

References

[1]"The complete genome of Nakamurella multipartita DSM 44233."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Sims D., Meincke L., Brettin T., Detter J.C., Han C. expand/collapse author list , Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Klenk H.-P., Eisen J.A.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700099 / DSM 44233 / JCM 9543 / Y-104.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001737 Genomic DNA. Translation: ACV77004.1.
RefSeqYP_003199993.1. NC_013235.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING479431.Namu_0589.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV77004; ACV77004; Namu_0589.
GeneID8446173.
KEGGnml:Namu_0589.
PATRIC22658686. VBINakMul62011_0594.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3844.
HOGENOMHOG000242437.
KOK01556.
OMAGRTIRWI.
OrthoDBEOG6N67XP.

Enzyme and pathway databases

BioCycNMUL479431:GHQL-596-MONOMER.
UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC8X828_NAKMY
AccessionPrimary (citable) accession number: C8X828
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: May 14, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)