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C8X828

- C8X828_NAKMY

UniProt

C8X828 - C8X828_NAKMY

Protein

Kynureninase

Gene

Namu_0589

Organism
Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / JCM 9543 / Y-104) (Microsphaera multipartita)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: UniProtKB-KW

    GO - Biological processi

    1. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    2. NAD biosynthetic process Source: UniProtKB-UniPathway
    3. tryptophan catabolic process Source: InterPro

    Keywords - Molecular functioni

    AminotransferaseImported, HydrolaseUniRule annotation, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciNMUL479431:GHQL-596-MONOMER.
    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
    Gene namesi
    Ordered Locus Names:Namu_0589Imported
    OrganismiNakamurella multipartita (strain ATCC 700099 / DSM 44233 / JCM 9543 / Y-104) (Microsphaera multipartita)Imported
    Taxonomic identifieri479431 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeNakamurellaceaeNakamurella
    ProteomesiUP000002218: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919 PotentialImportedAdd
    BLAST
    Chaini20 – 417398 PotentialImportedPRO_5000521841Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi479431.Namu_0589.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Phylogenomic databases

    eggNOGiCOG3844.
    HOGENOMiHOG000242437.
    KOiK01556.
    OMAiGRTIRWI.
    OrthoDBiEOG6N67XP.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C8X828-1 [UniParc]FASTAAdd to Basket

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    MSSLTTGAIT GSITRAQAQD LDRTDPLAGF RDRYLPATDD VVAYLDGNSL    50
    GRPLAAIADS WQRFTHEQWA GRLIRGWSEG WMDLPELVGD ELAAAALGAA 100
    PGQTIIADST TVNFYKAMRA ALNLRPGRTK IILDRDNFPT NRYVAESLAR 150
    DLGLELVWLE PPIDGGVTPE AVAAVIDERT AVVTLSHIAY QSAFLADAPA 200
    ITEVAHRAGA LVVWDLCHSV GSTEIELDAW DVDFAVGCTY KFVGAGPGAP 250
    ALLYANARHH AGLDQPIWGW LGRQDSFEME QGYRPAAGIR SMMSGTPPLL 300
    GLLAVREGAA VIAEAGIAAI RAKAVALTEM VTAIAEDTLV PQGFTVMSPC 350
    DPARRGGHVS IARPDARELS QRLTEAGVLI DFRAPQAIRI GLSPLPASFT 400
    EVWDAMEVIR TLSAPAH 417
    Length:417
    Mass (Da):44,580
    Last modified:November 3, 2009 - v1
    Checksum:iA52B22440F21C3AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001737 Genomic DNA. Translation: ACV77004.1.
    RefSeqiWP_015745921.1. NC_013235.1.
    YP_003199993.1. NC_013235.1.

    Genome annotation databases

    EnsemblBacteriaiACV77004; ACV77004; Namu_0589.
    GeneIDi8446173.
    KEGGinml:Namu_0589.
    PATRICi22658686. VBINakMul62011_0594.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001737 Genomic DNA. Translation: ACV77004.1 .
    RefSeqi WP_015745921.1. NC_013235.1.
    YP_003199993.1. NC_013235.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 479431.Namu_0589.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACV77004 ; ACV77004 ; Namu_0589 .
    GeneIDi 8446173.
    KEGGi nml:Namu_0589.
    PATRICi 22658686. VBINakMul62011_0594.

    Phylogenomic databases

    eggNOGi COG3844.
    HOGENOMi HOG000242437.
    KOi K01556.
    OMAi GRTIRWI.
    OrthoDBi EOG6N67XP.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .
    BioCyci NMUL479431:GHQL-596-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700099 / DSM 44233 / JCM 9543 / Y-104Imported.

    Entry informationi

    Entry nameiC8X828_NAKMY
    AccessioniPrimary (citable) accession number: C8X828
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3