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Protein

Kynureninase

Gene

Namu_0589

Organism
Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / JCM 9543 / Y-104) (Microsphaera multipartita)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: UniProtKB-KW

GO - Biological processi

  1. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  2. NAD biosynthetic process Source: UniProtKB-UniPathway
  3. tryptophan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseImported, HydrolaseUniRule annotation, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciNMUL479431:GHQL-596-MONOMER.
UniPathwayiUPA00253; UER00329.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Gene namesi
Ordered Locus Names:Namu_0589Imported
OrganismiNakamurella multipartita (strain ATCC 700099 / DSM 44233 / JCM 9543 / Y-104) (Microsphaera multipartita)Imported
Taxonomic identifieri479431 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeNakamurellaceaeNakamurella
ProteomesiUP000002218: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 PotentialImportedAdd
BLAST
Chaini20 – 417398 PotentialImportedPRO_5000521841Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi479431.Namu_0589.

Family & Domainsi

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242437.
KOiK01556.
OMAiRFWQPLS.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C8X828-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSLTTGAIT GSITRAQAQD LDRTDPLAGF RDRYLPATDD VVAYLDGNSL
60 70 80 90 100
GRPLAAIADS WQRFTHEQWA GRLIRGWSEG WMDLPELVGD ELAAAALGAA
110 120 130 140 150
PGQTIIADST TVNFYKAMRA ALNLRPGRTK IILDRDNFPT NRYVAESLAR
160 170 180 190 200
DLGLELVWLE PPIDGGVTPE AVAAVIDERT AVVTLSHIAY QSAFLADAPA
210 220 230 240 250
ITEVAHRAGA LVVWDLCHSV GSTEIELDAW DVDFAVGCTY KFVGAGPGAP
260 270 280 290 300
ALLYANARHH AGLDQPIWGW LGRQDSFEME QGYRPAAGIR SMMSGTPPLL
310 320 330 340 350
GLLAVREGAA VIAEAGIAAI RAKAVALTEM VTAIAEDTLV PQGFTVMSPC
360 370 380 390 400
DPARRGGHVS IARPDARELS QRLTEAGVLI DFRAPQAIRI GLSPLPASFT
410
EVWDAMEVIR TLSAPAH
Length:417
Mass (Da):44,580
Last modified:November 3, 2009 - v1
Checksum:iA52B22440F21C3AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001737 Genomic DNA. Translation: ACV77004.1.
RefSeqiWP_015745921.1. NC_013235.1.
YP_003199993.1. NC_013235.1.

Genome annotation databases

EnsemblBacteriaiACV77004; ACV77004; Namu_0589.
GeneIDi8446173.
KEGGinml:Namu_0589.
PATRICi22658686. VBINakMul62011_0594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001737 Genomic DNA. Translation: ACV77004.1.
RefSeqiWP_015745921.1. NC_013235.1.
YP_003199993.1. NC_013235.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi479431.Namu_0589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV77004; ACV77004; Namu_0589.
GeneIDi8446173.
KEGGinml:Namu_0589.
PATRICi22658686. VBINakMul62011_0594.

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242437.
KOiK01556.
OMAiRFWQPLS.
OrthoDBiEOG6N67XP.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
BioCyciNMUL479431:GHQL-596-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700099 / DSM 44233 / JCM 9543 / Y-104Imported.

Entry informationi

Entry nameiC8X828_NAKMY
AccessioniPrimary (citable) accession number: C8X828
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: February 4, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.