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C8X4E2

- C8X4E2_DESRD

UniProt

C8X4E2 - C8X4E2_DESRD

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Protein
Acetyl-coenzyme A synthetase
Gene
acsA, Dret_2132
Organism
Desulfohalobium retbaense (strain DSM 5692)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA By similarity.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei322 – 3221Coenzyme A By similarityUniRule annotation
Binding sitei398 – 3981Substrate; via nitrogen amide By similarityUniRule annotation
Binding sitei511 – 5111Substrate By similarityUniRule annotation
Binding sitei526 – 5261Substrate By similarityUniRule annotation
Active sitei528 – 5281 By similarityUniRule annotation
Binding sitei534 – 5341Coenzyme A By similarityUniRule annotation
Binding sitei537 – 5371Substrate By similarityUniRule annotation
Metal bindingi548 – 5481Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi550 – 5501Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi553 – 5531Magnesium; via carbonyl oxygen By similarityUniRule annotation
Binding sitei595 – 5951Coenzyme A By similarityUniRule annotation

GO - Molecular functioni

  1. AMP binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciDRET485915:GHRJ-2180-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene namesi
Name:acsAUniRule annotation
Ordered Locus Names:Dret_2132Imported
OrganismiDesulfohalobium retbaense (strain DSM 5692)Imported
Taxonomic identifieri485915 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfohalobiaceaeDesulfohalobium
ProteomesiUP000001052: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei620 – 6201N6-acetyllysine By similarityUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi485915.Dret_2132.

Structurei

3D structure databases

ProteinModelPortaliC8X4E2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni203 – 2064Coenzyme A By similarityUniRule annotation
Regioni422 – 4276Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiAWIWYRD.
OrthoDBiEOG68WR2H.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8X4E2-1 [UniParc]FASTAAdd to Basket

« Hide

MGGSDEHIES MMHERRHFPP PRHGSERAHI PGPEAYDDLR DQAARDPEGF    50
WAERAKALLD WDSEWDTVLE ADWETPEFKW FAGGKLNACA NCLDRHVASG 100
RGEKTALIWQ GEPEDDVRQF TYAELRDEVV KFAKVLKKWG VGKGDRVAVY 150
LPMIPELPIA MLACARIGAV HSVVFAGFSA HSLQNRIQDC EAKVLITADA 200
VIRAGKQIPL KTNGDEALEA CPSVEHCIVV NRAGLDVAMH EGRDVWWHDA 250
VAGDDGTDCP PESMDAEDLL FILYTSGSTG KPKGVVHTTG GYLTYTAQTT 300
QWVFDIQEDD VYWCTADIGW ITGHSYILYG PLALGATTVM FEGVPSYPQP 350
DRFWQVVEKF KVTIFYTAPT VIRALMREGP QWTETRDLSS LRLLGSVGEP 400
INPEAWMWYH DHVGKGELPV LDTWWQTETG GIMISAVPYA TTLKPGSASQ 450
PLPGIEADIV DRDGEPVGPN RGGHLVVKTP WPGMLRNVYG DPARYKSTYF 500
ERFPGMYESG DSARMDEEGY FWIMGRLDDV INVSGHRLGT AEIESALVAH 550
EAVAEAAVVG MPHEVKGQAI YAYVTLKSTF QENDELRKVL RQHVRTEIGA 600
IATPEIIQFA PGLPKTRSGK IMRRILRKIA ADETNAFGDT STLADPTVIA 650
DLIDGKNLLG K 661
Length:661
Mass (Da):73,245
Last modified:November 3, 2009 - v1
Checksum:i0B1F90A93F31B941
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001734 Genomic DNA. Translation: ACV69416.1.
RefSeqiWP_015752557.1. NC_013223.1.
YP_003198994.1. NC_013223.1.

Genome annotation databases

EnsemblBacteriaiACV69416; ACV69416; Dret_2132.
GeneIDi8419982.
KEGGidrt:Dret_2132.
PATRICi21701382. VBIDesRet71890_2248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001734 Genomic DNA. Translation: ACV69416.1 .
RefSeqi WP_015752557.1. NC_013223.1.
YP_003198994.1. NC_013223.1.

3D structure databases

ProteinModelPortali C8X4E2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 485915.Dret_2132.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACV69416 ; ACV69416 ; Dret_2132 .
GeneIDi 8419982.
KEGGi drt:Dret_2132.
PATRICi 21701382. VBIDesRet71890_2248.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi AWIWYRD.
OrthoDBi EOG68WR2H.

Enzyme and pathway databases

BioCyci DRET485915:GHRJ-2180-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 5692.

Entry informationi

Entry nameiC8X4E2_DESRD
AccessioniPrimary (citable) accession number: C8X4E2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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