C8WXQ5 (C8WXQ5_ALIAD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
UvrABC system protein C HAMAP-Rule MF_00203
Short name=Protein UvrC HAMAP-Rule MF_00203

Alternative name(s):
Excinuclease ABC subunit C HAMAP-Rule MF_00203

Gene names

Name:	uvrC HAMAP-Rule MF_00203
Ordered Locus Names:	Aaci_1864 EMBL ACV58876.1

Organism

Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius) [Complete proteome] [HAMAP] EMBL ACV58876.1

Taxonomic identifier

521098 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Alicyclobacillaceae › Alicyclobacillus › Alicyclobacillus acidocaldarius › Alicyclobacillus acidocaldarius

Protein attributes

Sequence length	610 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203 SAAS SAAS004791
Subunit structure	Interacts with UvrB in an incision complex By similarity. HAMAP-Rule MF_00203 SAAS SAAS004791
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00203 SAAS SAAS004791.
Sequence similarities	Belongs to the UvrC family. HAMAP-Rule MF_00203 Contains 1 GIY-YIG domain. HAMAP-Rule MF_00203 SAAS SAAS004791 Contains 1 UVR domain. HAMAP-Rule MF_00203 SAAS SAAS004791

Ontologies

Keywords
Biological process	DNA damage DNA excision HAMAP-Rule MF_00203 SAAS SAAS004791 DNA repair SOS response HAMAP-Rule MF_00203 SAAS SAAS004791
Cellular component	Cytoplasm HAMAP-Rule MF_00203 SAAS SAAS004791
Molecular function	Excision nuclease HAMAP-Rule MF_00203 SAAS SAAS004791
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	SOS response Inferred from electronic annotation. Source: HAMAP nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Domain	14 – 91	78	GIY-YIG By similarity HAMAP-Rule MF_00203
	Domain	196 – 231	36	UVR By similarity HAMAP-Rule MF_00203

Sequences

	Sequence		Length	Mass (Da)
	C8WXQ5 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: 6798D19B5FAF965B	FASTA	610	69,889
	10 20 30 40 50 60 MNQVIRDKLD LLPQRPGVYL MKGEGGEILY VGKAKVLRNR VRSYFTGTHD TKTQVLVSQI 70 80 90 100 110 120 RDFEYIVTDT VAEALLLECN LIKQHQPPYN IMLRDDKSYP YIKLTKERHP RLQIVRQVKR 130 140 150 160 170 180 DGAKYFGPYP NATSAQATKR LLDRLYPLRK CKTLKKQVCL YYHIHQCLAP CVYDVDEATY 190 200 210 220 230 240 EAMAKEISHF LNGGHQDVVR ELEQKMQAAA ESLEFERAAE LRDLIRHIEQ VMQEQKVTWT 250 260 270 280 290 300 DGIDRDVFGF AEDRGLLSVQ VFFVRNGKLI ERQVQIAPHF DDPLTDFMSF VEQFYHERVD 310 320 330 340 350 360 LPKEILLPEG VPSEALAMVV DAKVLQPKRG PKRDLVDLAC ENARQALAEK IQLIDRNLDR 370 380 390 400 410 420 TLGAVMELGQ VLAIQPPRRI EAFDNSNFQG VDAVSAMVVF IDGKPAKSEY RKYKIRSTQG 430 440 450 460 470 480 PDDYEAIREV VRRRYSRLVR EQKPLPDLVV IDGGKGQLRA ALSVLEGELG LEIPVCGLAK 490 500 510 520 530 540 DERHRTSQLF FMDEEEPVRI ERHSPAFYLL ERIQDEVHRF AVEFHRLRRS KTGFQSILDE 550 560 570 580 590 600 IPGVGPERKK AILRRFGSLK AVAAAQPEDF RGLGIGDKLA REIVARVREE LAARKQADGE 610 MEISSEAPFS

References

[1]

"The complete chromosome of Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446." US DOE Joint Genome Institute (JGI-PGF) Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Chertkov O., Sims D., Brettin T., Detter J.C., Han C. , Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Pukall R., Klenk H.-P., Eisen J.A. Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27009 / DSM 446 / 104-1A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001727 Genomic DNA. Translation: ACV58876.1.
RefSeq	YP_003185265.1. NC_013205.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	521098.Aaci_1864.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACV58876; ACV58876; Aaci_1864.
GeneID	8425381.
KEGG	aac:Aaci_1864.
PATRIC	20847162. VBIAliAci73240_1814.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0322.
HOGENOM	HOG000279960.
KO	K03703.
OMA	QKLFPIR.
ProtClustDB	CLSK2821224.
Family and domain databases
Gene3D	3.40.1440.10. 1 hit. 4.10.860.10. 1 hit.
HAMAP	MF_00203. UvrC.
InterPro	IPR027299. GIY-YIG_dom. IPR000305. GIY-YIG_SF. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR010994. RuvA_2-like. IPR001943. UVR_dom. IPR004791. UvrC. IPR001162. UvrC_homol_region. [Graphical view]
Pfam	PF01541. GIY-YIG. 1 hit. PF02151. UVR. 1 hit. PF08459. UvrC_HhH_N. 1 hit. [Graphical view]
SMART	SM00465. GIYc. 1 hit. SM00278. HhH1. 1 hit. [Graphical view]
SUPFAM	SSF47781. RuvA_2_like. 1 hit. SSF46600. UvrB_C. 1 hit. SSF82771. UvrC_N. 1 hit.
TIGRFAMs	TIGR00194. uvrC. 1 hit.
PROSITE	PS50164. GIY_YIG. 1 hit. PS50151. UVR. 1 hit. PS50165. UVRC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C8WXQ5_ALIAD

Accession

Primary (citable) accession number: C8WXQ5

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)