C8WWJ9 (C8WWJ9_ALIAD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116

Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116

Gene names

Name:	dut HAMAP MF_00116
Ordered Locus Names:	Aaci_1445

Organism

Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius) [Complete proteome] [HAMAP]

Taxonomic identifier

521098 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Alicyclobacillaceae › Alicyclobacillus

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116 SAAS SAAS008181
Catalytic activity	dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116 SAAS SAAS008181
Cofactor	Magnesium By similarity. HAMAP MF_00116 SAAS SAAS008181
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116
Sequence similarities	Belongs to the dUTPase family. HAMAP MF_00116

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00116 SAAS SAAS008181
Ligand	Magnesium HAMAP MF_00116 SAAS SAAS008181 Metal-binding HAMAP MF_00116 SAAS SAAS008181
Molecular function	Hydrolase HAMAP MF_00116 SAAS SAAS008181 EMBL ACV58470.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	68 – 70	3	Substrate binding By similarity HAMAP MF_00116
	Region	85 – 87	3	Substrate binding By similarity HAMAP MF_00116
Sites
	Binding site	81	1	Substrate By similarity HAMAP MF_00116

Sequences

	Sequence		Length	Mass (Da)
	C8WWJ9 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: E1D299BFB57A20B6	FASTA	149	15,624
	10 20 30 40 50 60 MEVKVQIVSP LLTADDLPQY ATQGSAGMDL RACLEAPRVV RPGEIVPVPT GLAIQLPRRD 70 80 90 100 110 120 AVALVYARSG LAAKHGIALA NGVGVIDSDY TGEIVVPLHH FGSKEFVLQP KERIAQLVIA 130 140 PIYVARLVAV DHLGPTARGA GGFGSTGRV

References

[1]

"The complete chromosome of Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Chertkov O., Sims D., Brettin T., Detter J.C., Han C. , Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Pukall R., Klenk H.-P., Eisen J.A. Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27009 / DSM 446 / 104-1A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001727 Genomic DNA. Translation: ACV58470.1.
RefSeq	YP_003184859.1. NC_013205.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C8WWJ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8424952.
GenomeReviews	Gene locus Aaci_1445 in contig CP001727_GR.
KEGG	aac:Aaci_1445.
PATRIC	20846324. VBIAliAci73240_1406.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LDLRACI.
Family and domain databases
HAMAP	MF_00116. dUTPase_bact. [Tree]
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
KO	K01520.
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. Dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C8WWJ9_ALIAD

Accession

Primary (citable) accession number: C8WWJ9

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	December 14, 2011
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)