ID   C8WWG6_ALIAD            Unreviewed;       682 AA.
AC   C8WWG6;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN   Name=flhA {ECO:0000256|RuleBase:RU364093};
GN   OrderedLocusNames=Aaci_1410 {ECO:0000313|EMBL:ACV58437.1};
OS   Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 /
OS   DSM 446 / BCRC 14685 / JCM 5260 / KCTC 1825 / NBRC 15652 / NCIMB 11725 /
OS   NRRL B-14509 / 104-IA) (Bacillus acidocaldarius).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC   Alicyclobacillus.
OX   NCBI_TaxID=521098 {ECO:0000313|EMBL:ACV58437.1, ECO:0000313|Proteomes:UP000001917};
RN   [1] {ECO:0000313|Proteomes:UP000001917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27009 / DSM 446 / BCRC 14685 / JCM 5260 / KCTC 1825 / NBRC
RC   15652 / NCIMB 11725 / NRRL B-14509 / 104-IA
RC   {ECO:0000313|Proteomes:UP000001917};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA   Ovchinnikova G., Chertkov O., Sims D., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA   Woyke T., Wu D., Pukall R., Klenk H.-P., Eisen J.A.;
RT   "The complete chromosome of Alicyclobacillus acidocaldarius subsp.
RT   acidocaldarius DSM 446.";
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACV58437.1, ECO:0000313|Proteomes:UP000001917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27009 / DSM 446 / BCRC 14685 / JCM 5260 / KCTC 1825 / NBRC
RC   15652 / NCIMB 11725 / NRRL B-14509 / 104-IA
RC   {ECO:0000313|Proteomes:UP000001917};
RX   PubMed=21304673; DOI=10.4056/sigs.591104;
RA   Mavromatis K., Sikorski J., Lapidus A., Glavina Del Rio T., Copeland A.,
RA   Tice H., Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D., Goodwin L.,
RA   Pitluck S., Ivanova N., Ovchinnikova G., Pati A., Chen A., Palaniappan K.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Chain P., Meincke L.,
RA   Sims D., Chertkov O., Han C., Brettin T., Detter J.C., Wahrenburg C.,
RA   Rohde M., Pukall R., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT   "Complete genome sequence of Alicyclobacillus acidocaldarius type strain
RT   (104-IA).";
RL   Stand. Genomic Sci. 2:9-18(2010).
CC   -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC       apparatus. Together with FliI and FliH, may constitute the export
CC       apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC       pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC       ECO:0000256|RuleBase:RU364093}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU364093}.
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DR   EMBL; CP001727; ACV58437.1; -; Genomic_DNA.
DR   RefSeq; WP_012810757.1; NC_013205.1.
DR   AlphaFoldDB; C8WWG6; -.
DR   STRING; 521098.Aaci_1410; -.
DR   KEGG; aac:Aaci_1410; -.
DR   eggNOG; COG1298; Bacteria.
DR   HOGENOM; CLU_015346_3_0_9; -.
DR   Proteomes; UP000001917; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR   Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR   Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR   InterPro; IPR042194; FHIPEP_1.
DR   InterPro; IPR042193; FHIPEP_3.
DR   InterPro; IPR042196; FHIPEP_4.
DR   InterPro; IPR006301; FlhA.
DR   InterPro; IPR001712; T3SS_FHIPEP.
DR   NCBIfam; TIGR01398; FlhA; 1.
DR   PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR   PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR   Pfam; PF00771; FHIPEP; 1.
DR   PIRSF; PIRSF005419; FlhA; 1.
DR   PRINTS; PR00949; TYPE3IMAPROT.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW   Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU364093};
KW   Cell projection {ECO:0000313|EMBL:ACV58437.1};
KW   Cilium {ECO:0000313|EMBL:ACV58437.1};
KW   Flagellum {ECO:0000313|EMBL:ACV58437.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW   Protein transport {ECO:0000256|RuleBase:RU364093};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001917};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU364093};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT   TRANSMEM        12..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364093"
FT   TRANSMEM        34..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364093"
FT   TRANSMEM        105..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364093"
FT   TRANSMEM        192..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364093"
FT   TRANSMEM        234..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364093"
FT   TRANSMEM        275..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU364093"
SQ   SEQUENCE   682 AA;  75005 MW;  557BC67AA7BE5EC2 CRC64;
     MANWLKRTDL MVMLFVLWTI VMIVIPIPRP LLDVLILFNM FVSMTILLVA MNTSEPLEFS
     IFPSLLLVTT LYRLSLNIST TRLILSQGNA GAVIQTFGNF VIGNNPVVGF IVFLIIIIVQ
     YVVITRGAER VAEVAARFTL DAMPGKQLAI DADLNAGLIQ EAEARRRREK IQQEADFYGA
     MDGASKFVKG DAIASMVIVA INVVAGLIIG VAMQHDSFSE ALHTYTMLSV GDGLVSQIPA
     LLLSTATGLM VSRAATDQNM GADVVKQVFG YARALYVVSG AIVLLGLITP IGILPVIPIA
     GGATLMARRA ERSRALQQKR EEEEKARQKR SEAKKPENVY QLITVEPVEF EFGYGLIPLV
     DARQGGDFME RVAMIRRQLA TDLGVVLPMV RMRDNVLLKP TQYVIKLKGV EVARGEILMG
     HWLALSPGID NPEVKGIPTK DPTFGLPALW VTGEMKLRAE ASGYTVVDPP SVMATHLTEV
     LRRHAHELLG RQQVKELLEH LKQTHPAVVE DVYPGTLSLG HIQRVLCNLL EEGVPIRDLV
     TILEALADAG RQTQDVDQLT EKVRQRLARH ICAQYLQGED GLTVLTFDPA LEREMQQAVV
     EQGGALSIGL EPQKAQAVFR KLKELWTELQ GTGKSPVLLV HPRIRLPLSR LVRRYVPDLP
     VLSFAELDPS ISIHSGGVVN VT
//