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Protein

Isocitrate dehydrogenase [NADP]

Gene

Aaci_2348

Organism
Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / JCM 5260 / NBRC 15652 / NCIMB 11725 / NRRL B-14509 / 104-1A) (Bacillus acidocaldarius)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium or manganese ion per subunit.
  • Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciAACI521098:GCIO-2419-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Aaci_2348Imported
OrganismiAlicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / JCM 5260 / NBRC 15652 / NCIMB 11725 / NRRL B-14509 / 104-1A) (Bacillus acidocaldarius)Imported
Taxonomic identifieri521098 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesAlicyclobacillaceaeAlicyclobacillus
ProteomesiUP000001917 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi521098.Aaci_2348.

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8WRU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTFERYQLP TEGEPITLVD GKLNVPDHPI IPFIEGDGTG PDIWRAAQRV
60 70 80 90 100
FDAAVEKAYG GKRKIAWYEV YAGEKAYNMF GEWLPQDTLT ALSEYIVSIK
110 120 130 140 150
GPLTTPVGGG IRSLNVAVRQ ELDLYVCQRP VRYFQGVPSP VKHPELVDMV
160 170 180 190 200
IFRENSEDIY AGIEWQAGTP EVKKVIEFLQ KEMGVKKIRF PETSGIGVKP
210 220 230 240 250
VSREGTERLV RAAIEYALRH KRKSVTLVHK GNIMKFTEGA FKNWGYELAE
260 270 280 290 300
REFSDKVFTW AQYDRIKAEK GQEAADAAQK EAIEAGKLIV KDVIADAFLQ
310 320 330 340 350
QILTRPAEYD VIATLNLNGD YISDALAAQV GGIGIAPGAN INYETGHAVF
360 370 380 390 400
EATHGTAPKY AGLDKVNPGS VILSGVMMFE YMGWQEAADL ITRAMEKTIA
410 420 430
QKIVTYDFAR LMEGATEVKC SEFGDHIIQN MG
Length:432
Mass (Da):47,978
Last modified:November 3, 2009 - v1
Checksum:i2A458EC5689FB640
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001727 Genomic DNA. Translation: ACV59355.1.
RefSeqiWP_012811600.1. NC_013205.1.

Genome annotation databases

EnsemblBacteriaiACV59355; ACV59355; Aaci_2348.
KEGGiaac:Aaci_2348.
PATRICi20848190. VBIAliAci73240_2318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001727 Genomic DNA. Translation: ACV59355.1.
RefSeqiWP_012811600.1. NC_013205.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi521098.Aaci_2348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV59355; ACV59355; Aaci_2348.
KEGGiaac:Aaci_2348.
PATRICi20848190. VBIAliAci73240_2318.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciAACI521098:GCIO-2419-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27009 / DSM 446 / JCM 5260 / NBRC 15652 / NCIMB 11725 / NRRL B-14509 / 104-1AImported.

Entry informationi

Entry nameiC8WRU4_ALIAD
AccessioniPrimary (citable) accession number: C8WRU4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: July 22, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.