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C8WRU4

- C8WRU4_ALIAD

UniProt

C8WRU4 - C8WRU4_ALIAD

Protein

Isocitrate dehydrogenase [NADP]

Gene

Aaci_2348

Organism
Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciAACI521098:GCIO-2419-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Aaci_2348Imported
    OrganismiAlicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius)Imported
    Taxonomic identifieri521098 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesAlicyclobacillaceaeAlicyclobacillus
    ProteomesiUP000001917: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi521098.Aaci_2348.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C8WRU4-1 [UniParc]FASTAAdd to Basket

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    MPTFERYQLP TEGEPITLVD GKLNVPDHPI IPFIEGDGTG PDIWRAAQRV    50
    FDAAVEKAYG GKRKIAWYEV YAGEKAYNMF GEWLPQDTLT ALSEYIVSIK 100
    GPLTTPVGGG IRSLNVAVRQ ELDLYVCQRP VRYFQGVPSP VKHPELVDMV 150
    IFRENSEDIY AGIEWQAGTP EVKKVIEFLQ KEMGVKKIRF PETSGIGVKP 200
    VSREGTERLV RAAIEYALRH KRKSVTLVHK GNIMKFTEGA FKNWGYELAE 250
    REFSDKVFTW AQYDRIKAEK GQEAADAAQK EAIEAGKLIV KDVIADAFLQ 300
    QILTRPAEYD VIATLNLNGD YISDALAAQV GGIGIAPGAN INYETGHAVF 350
    EATHGTAPKY AGLDKVNPGS VILSGVMMFE YMGWQEAADL ITRAMEKTIA 400
    QKIVTYDFAR LMEGATEVKC SEFGDHIIQN MG 432
    Length:432
    Mass (Da):47,978
    Last modified:November 3, 2009 - v1
    Checksum:i2A458EC5689FB640
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001727 Genomic DNA. Translation: ACV59355.1.
    RefSeqiWP_012811600.1. NC_013205.1.
    YP_003185744.1. NC_013205.1.

    Genome annotation databases

    EnsemblBacteriaiACV59355; ACV59355; Aaci_2348.
    GeneIDi8425877.
    KEGGiaac:Aaci_2348.
    PATRICi20848190. VBIAliAci73240_2318.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001727 Genomic DNA. Translation: ACV59355.1 .
    RefSeqi WP_012811600.1. NC_013205.1.
    YP_003185744.1. NC_013205.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 521098.Aaci_2348.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACV59355 ; ACV59355 ; Aaci_2348 .
    GeneIDi 8425877.
    KEGGi aac:Aaci_2348.
    PATRICi 20848190. VBIAliAci73240_2318.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci AACI521098:GCIO-2419-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27009 / DSM 446 / 104-1AImported.

    Entry informationi

    Entry nameiC8WRU4_ALIAD
    AccessioniPrimary (citable) accession number: C8WRU4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3