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Protein

Isocitrate dehydrogenase [NADP]

Gene

Aaci_2348

Organism
Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / JCM 5260 / NBRC 15652 / NCIMB 11725 / NRRL B-14509 / 104-1A) (Bacillus acidocaldarius)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseImported
Biological processGlyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Aaci_2348Imported
OrganismiAlicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / JCM 5260 / NBRC 15652 / NCIMB 11725 / NRRL B-14509 / 104-1A) (Bacillus acidocaldarius)Imported
Taxonomic identifieri521098 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesAlicyclobacillaceaeAlicyclobacillus
Proteomesi
  • UP000001917 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi521098.Aaci_2348.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 427Iso_dhInterPro annotationAdd BLAST398

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFQQIQTR.
OrthoDBiPOG091H01VB.

Family and domain databases

InterProiView protein in InterPro
IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
PANTHERiPTHR43504. PTHR43504. 1 hit.
PfamiView protein in Pfam
PF00180. Iso_dh. 1 hit.
SMARTiView protein in SMART
SM01329. Iso_dh. 1 hit.
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiView protein in PROSITE
PS00470. IDH_IMDH. 1 hit.

Sequencei

Sequence statusi: Complete.

C8WRU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTFERYQLP TEGEPITLVD GKLNVPDHPI IPFIEGDGTG PDIWRAAQRV
60 70 80 90 100
FDAAVEKAYG GKRKIAWYEV YAGEKAYNMF GEWLPQDTLT ALSEYIVSIK
110 120 130 140 150
GPLTTPVGGG IRSLNVAVRQ ELDLYVCQRP VRYFQGVPSP VKHPELVDMV
160 170 180 190 200
IFRENSEDIY AGIEWQAGTP EVKKVIEFLQ KEMGVKKIRF PETSGIGVKP
210 220 230 240 250
VSREGTERLV RAAIEYALRH KRKSVTLVHK GNIMKFTEGA FKNWGYELAE
260 270 280 290 300
REFSDKVFTW AQYDRIKAEK GQEAADAAQK EAIEAGKLIV KDVIADAFLQ
310 320 330 340 350
QILTRPAEYD VIATLNLNGD YISDALAAQV GGIGIAPGAN INYETGHAVF
360 370 380 390 400
EATHGTAPKY AGLDKVNPGS VILSGVMMFE YMGWQEAADL ITRAMEKTIA
410 420 430
QKIVTYDFAR LMEGATEVKC SEFGDHIIQN MG
Length:432
Mass (Da):47,978
Last modified:November 3, 2009 - v1
Checksum:i2A458EC5689FB640
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001727 Genomic DNA. Translation: ACV59355.1.
RefSeqiWP_012811600.1. NC_013205.1.

Genome annotation databases

EnsemblBacteriaiACV59355; ACV59355; Aaci_2348.
KEGGiaac:Aaci_2348.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiC8WRU4_ALIAD
AccessioniPrimary (citable) accession number: C8WRU4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: June 7, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported