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Protein

Xylose isomerase

Gene

xylA

Organism
Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / JCM 5260 / NBRC 15652 / NCIMB 11725 / NRRL B-14509 / 104-1A) (Bacillus acidocaldarius)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102UniRule annotation1
Active sitei105UniRule annotation1
Metal bindingi233Magnesium 1UniRule annotation1
Metal bindingi269Magnesium 1UniRule annotation1
Metal bindingi269Magnesium 2UniRule annotation1
Metal bindingi272Magnesium 2UniRule annotation1
Metal bindingi297Magnesium 1UniRule annotation1
Metal bindingi308Magnesium 2UniRule annotation1
Metal bindingi310Magnesium 2UniRule annotation1
Metal bindingi340Magnesium 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotation, Xylose metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotationSAAS annotation (EC:5.3.1.5UniRule annotationSAAS annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:Aaci_2180Imported
OrganismiAlicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / JCM 5260 / NBRC 15652 / NCIMB 11725 / NRRL B-14509 / 104-1A) (Bacillus acidocaldarius)Imported
Taxonomic identifieri521098 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesAlicyclobacillaceaeAlicyclobacillus
Proteomesi
  • UP000001917 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi521098.Aaci_2180.

Structurei

3D structure databases

ProteinModelPortaliC8WR20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 285AP_endonuc_2InterPro annotationAdd BLAST190

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiPOG091H07LC.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8WR20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVATYFPEV TRIAYEGKRS DNPLSFKYYN PDEIVLGKPM KEHLRFSVAY
60 70 80 90 100
WHTFTLSGAD PFGLPNMIRP WDGATGMDLA KRRVEAAFEF MTKLGVEYFC
110 120 130 140 150
FHDRDIAPEG DTLRETNRNL DEIVALIKEY MQSTGIKLLW NTQNLFSNPR
160 170 180 190 200
FAHGAATAPD ADVFAYAAAQ VKKSLEIAKE LGAENYVFWG GREGYETLLN
210 220 230 240 250
TDLKLELDNY ARLLQMAVDY ADEIGFTGQF LIEPKPKEPT KHQYDFDVQS
260 270 280 290 300
GLAFLYHYGL KDRFKFNIEA NHATLAGHTF QHELRFARIH GLLGSVDANQ
310 320 330 340 350
GDPLLGWDTD EFPTNLYETT LAMYEILLNG GLAPGGLNFD AKVRRASMTP
360 370 380 390 400
IDLFYGHIAG MDSFARGLKV AAKLLEDRVF EREIEERYES YRTGIGKDIV
410 420 430 440
EGRATLKSLE SYVIDKRVTA TRSGRQEVLL AKLNQYLLET E
Length:441
Mass (Da):50,094
Last modified:November 3, 2009 - v1
Checksum:iFE0920E34DE4394E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001727 Genomic DNA. Translation: ACV59189.1.
RefSeqiWP_012811447.1. NC_013205.1.

Genome annotation databases

EnsemblBacteriaiACV59189; ACV59189; Aaci_2180.
KEGGiaac:Aaci_2180.
PATRICi20847832. VBIAliAci73240_2146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001727 Genomic DNA. Translation: ACV59189.1.
RefSeqiWP_012811447.1. NC_013205.1.

3D structure databases

ProteinModelPortaliC8WR20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi521098.Aaci_2180.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV59189; ACV59189; Aaci_2180.
KEGGiaac:Aaci_2180.
PATRICi20847832. VBIAliAci73240_2146.

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiPOG091H07LC.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC8WR20_ALIAD
AccessioniPrimary (citable) accession number: C8WR20
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.