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C8WPW2 (C8WPW2_EGGLE) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Elen_3114 EMBL ACV57056.1
OrganismEggerthella lenta (strain ATCC 25559 / DSM 2243 / JCM 9979 / NCTC 11813 / VPI 0255) (Eubacterium lentum) [Complete proteome] [HAMAP] EMBL ACV57056.1
Taxonomic identifier479437 [NCBI]
Taxonomic lineageBacteriaActinobacteriaCoriobacteridaeCoriobacterialesCoriobacterineaeCoriobacteriaceaeEggerthella

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain103 – 303201ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding131 – 18656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2571Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2701Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2701Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2721Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C8WPW2 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: 387219EFAFD970D7

FASTA30732,653
        10         20         30         40         50         60 
MSECRVALLA GGKSGEREVS LASAEGAREA LEEAGYTVTQ LDPADKEDLK RLIDGPFDVA 

        70         80         90        100        110        120 
FLCLHGKYGE DGTVQGLLET IGLPYIGSGV WSSALAMDKV KSKLYYEQAG ILTPPSVPLQ 

       130        140        150        160        170        180 
KGDSYDVDSI VEKLGTHCVV KPGTEGSALG VFIVEGAAAI GEAIEKAFDI DSEVLVERYI 

       190        200        210        220        230        240 
KGKELTVAVI GDAEVEALPI IEIVPKSDFY DFESKYAPGG SQHLCPAPLS DETTRMVQEL 

       250        260        270        280        290        300 
AVRAHRALSC EGVSRSDFIL EEDGSCWTLE TNTIPGMTGT SLLPDAARAA GISFPELCTR 


LIGYALS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001726 Genomic DNA. Translation: ACV57056.1.
RefSeqYP_003183445.1. NC_013204.1.

3D structure databases

ProteinModelPortalC8WPW2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING479437.Elen_3114.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV57056; ACV57056; Elen_3114.
GeneID8417450.
KEGGele:Elen_3114.
PATRIC21847065. VBIEggLen106823_3205.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OrthoDBEOG6ND0KB.
ProtClustDBCLSK2556009.

Enzyme and pathway databases

BioCycELEN479437:GHWY-3175-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC8WPW2_EGGLE
AccessionPrimary (citable) accession number: C8WPW2
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)