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C8WN09

- C8WN09_EGGLE

UniProt

C8WN09 - C8WN09_EGGLE

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Protein

Alanine racemase

Gene

Elen_2785

Organism
Eggerthella lenta (strain ATCC 25559 / DSM 2243 / JCM 9979 / NCTC 11813 / VPI 0255) (Eubacterium lentum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei100 – 1001Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei198 – 1981SubstrateUniRule annotation
Active sitei327 – 3271Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei375 – 3751Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciELEN479437:GHWY-2836-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Elen_2785Imported
OrganismiEggerthella lenta (strain ATCC 25559 / DSM 2243 / JCM 9979 / NCTC 11813 / VPI 0255) (Eubacterium lentum)Imported
Taxonomic identifieri479437 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCoriobacteridaeCoriobacterialesCoriobacterineaeCoriobacteriaceaeEggerthella
ProteomesiUP000001377: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi479437.Elen_2785.

Structurei

3D structure databases

ProteinModelPortaliC8WN09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8WN09-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTPRYVGEQ PPAGNAANKG AYEAATAAFS SGAEGAFQYA RDHARPDGEP
60 70 80 90 100
AQFDPDKLRL IPDVDRRWSW TEIDLNAIRH NTSAVKQRID NGVRLMAVVK
110 120 130 140 150
ADGYGHGAVR CAKTALNSGA DYLGVATVNE AIELREALVN APILVLSQPP
160 170 180 190 200
ETAIPLLLAY KVMPSVYTSE FAIQYAEAAD AYGVRAPYHL AVNTGMNRIG
210 220 230 240 250
VRHDEVVEFM GQVSFHRALD LVGTFTHFAT ADSAETLDFQ IQVKRFIEAV
260 270 280 290 300
TALRTAGVNP GIVHAANSAA AIRYPDVQFD MVRLGIAMYG LHPSGVTRPM
310 320 330 340 350
IDLHPAMSVH ARITDVRTVP MSEGVSYGMN YRSPGSVKIC TVPVGYADGL
360 370 380 390 400
RRGLSGRTDV ILKGQRCHQV GNICMDQCMF EVDLRVYGSR RRLDPMIGDE
410 420 430 440
VLLVGREGDS VITLDDMANT LGTINYELAC GFSLRMPRVY V
Length:441
Mass (Da):47,990
Last modified:November 3, 2009 - v1
Checksum:iD53B377D9FCFAAEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001726 Genomic DNA. Translation: ACV56732.1.
RefSeqiYP_003183121.1. NC_013204.1.

Genome annotation databases

EnsemblBacteriaiACV56732; ACV56732; Elen_2785.
GeneIDi8417111.
KEGGiele:Elen_2785.
PATRICi21846353. VBIEggLen106823_2859.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001726 Genomic DNA. Translation: ACV56732.1 .
RefSeqi YP_003183121.1. NC_013204.1.

3D structure databases

ProteinModelPortali C8WN09.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 479437.Elen_2785.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACV56732 ; ACV56732 ; Elen_2785 .
GeneIDi 8417111.
KEGGi ele:Elen_2785.
PATRICi 21846353. VBIEggLen106823_2859.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci ELEN479437:GHWY-2836-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25559 / DSM 2243 / JCM 9979 / NCTC 11813 / VPI 0255Imported.

Entry informationi

Entry nameiC8WN09_EGGLE
AccessioniPrimary (citable) accession number: C8WN09
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: November 26, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3