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C8WN09

- C8WN09_EGGLE

UniProt

C8WN09 - C8WN09_EGGLE

Protein

Alanine racemase

Gene

Elen_2785

Organism
Eggerthella lenta (strain ATCC 25559 / DSM 2243 / JCM 9979 / NCTC 11813 / VPI 0255) (Eubacterium lentum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei100 – 1001Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei198 – 1981SubstrateUniRule annotation
    Active sitei327 – 3271Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei375 – 3751Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciELEN479437:GHWY-2836-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Elen_2785Imported
    OrganismiEggerthella lenta (strain ATCC 25559 / DSM 2243 / JCM 9979 / NCTC 11813 / VPI 0255) (Eubacterium lentum)Imported
    Taxonomic identifieri479437 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaCoriobacteridaeCoriobacterialesCoriobacterineaeCoriobacteriaceaeEggerthella
    ProteomesiUP000001377: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei100 – 1001N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi479437.Elen_2785.

    Structurei

    3D structure databases

    ProteinModelPortaliC8WN09.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C8WN09-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTPRYVGEQ PPAGNAANKG AYEAATAAFS SGAEGAFQYA RDHARPDGEP    50
    AQFDPDKLRL IPDVDRRWSW TEIDLNAIRH NTSAVKQRID NGVRLMAVVK 100
    ADGYGHGAVR CAKTALNSGA DYLGVATVNE AIELREALVN APILVLSQPP 150
    ETAIPLLLAY KVMPSVYTSE FAIQYAEAAD AYGVRAPYHL AVNTGMNRIG 200
    VRHDEVVEFM GQVSFHRALD LVGTFTHFAT ADSAETLDFQ IQVKRFIEAV 250
    TALRTAGVNP GIVHAANSAA AIRYPDVQFD MVRLGIAMYG LHPSGVTRPM 300
    IDLHPAMSVH ARITDVRTVP MSEGVSYGMN YRSPGSVKIC TVPVGYADGL 350
    RRGLSGRTDV ILKGQRCHQV GNICMDQCMF EVDLRVYGSR RRLDPMIGDE 400
    VLLVGREGDS VITLDDMANT LGTINYELAC GFSLRMPRVY V 441
    Length:441
    Mass (Da):47,990
    Last modified:November 3, 2009 - v1
    Checksum:iD53B377D9FCFAAEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001726 Genomic DNA. Translation: ACV56732.1.
    RefSeqiYP_003183121.1. NC_013204.1.

    Genome annotation databases

    EnsemblBacteriaiACV56732; ACV56732; Elen_2785.
    GeneIDi8417111.
    KEGGiele:Elen_2785.
    PATRICi21846353. VBIEggLen106823_2859.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001726 Genomic DNA. Translation: ACV56732.1 .
    RefSeqi YP_003183121.1. NC_013204.1.

    3D structure databases

    ProteinModelPortali C8WN09.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 479437.Elen_2785.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACV56732 ; ACV56732 ; Elen_2785 .
    GeneIDi 8417111.
    KEGGi ele:Elen_2785.
    PATRICi 21846353. VBIEggLen106823_2859.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci ELEN479437:GHWY-2836-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25559 / DSM 2243 / JCM 9979 / NCTC 11813 / VPI 0255Imported.

    Entry informationi

    Entry nameiC8WN09_EGGLE
    AccessioniPrimary (citable) accession number: C8WN09
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3