C8WAB3 (C8WAB3_ATOPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
EC=6.3.4.3 HAMAP-Rule MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP-Rule MF_01543

Gene names

Name:	fhs HAMAP-Rule MF_01543
Ordered Locus Names:	Apar_0621

Organism

Atopobium parvulum (strain ATCC 33793 / DSM 20469 / JCM 10300 / VPI 0546) (Streptococcus parvulus) (Peptostreptococcus parvulus) [Complete proteome] [HAMAP]

Taxonomic identifier

521095 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Coriobacteridae › Coriobacteriales › Coriobacterineae › Coriobacteriaceae › Atopobium › Atopobium parvulum

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543 SAAS SAAS000559
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543 SAAS SAAS000559
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP-Rule MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP-Rule MF_01543 SAAS SAAS000559
Ligand	ATP-binding HAMAP-Rule MF_01543 SAAS SAAS000559 Nucleotide-binding
Molecular function	Ligase HAMAP-Rule MF_01543 SAAS SAAS000559 EMBL ACV51051.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro tetrahydrofolate interconversion Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	66 – 73	8	ATP By similarity HAMAP-Rule MF_01543

Sequences

	Sequence		Length	Mass (Da)
	C8WAB3 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: 5A4A219D7579E933	FASTA	557	59,535
	10 20 30 40 50 60 MSEVKSDIEI AQSSEMLPIF EVAKRAGISE DLLEPYGRYK AKLDARALAD KPLRGKLVLV 70 80 90 100 110 120 TAINPTPAGE GKTTTSVGLA DALTSLGQSA MLALREPSLG PVFGVKGGAA GGGYAQVVPM 130 140 150 160 170 180 EDINLHFTGD FHAIGAANNL CAAMLDNHIK QGNSLNIDPR RIVWKRCVDM NDRQLRNVVD 190 200 210 220 230 240 GLGGIADGMP RQDGFDITVA SEVMAVFCLA SGIKDLKERL GRMVIAYTYD RKPVTVSDIH 250 260 270 280 290 300 AEGAMTALLK DAIQPNLVQT LEHTPALVHG GPFANIAHGC NTVEATKTAL RLADYVVTEA 310 320 330 340 350 360 GFGADLGAEK FLDIKCRATG LAPSAVVLVA TVRALKYNGG VAKADLNQQN VEALKEGIPN 370 380 390 400 410 420 LLRHVDNIQT VYGLPVVVAI NAFPTDTAEE LALVEEECKK RGVNVVLSEV WAKGGKGGQA 430 440 450 460 470 480 LAEEVMRLCQ TESKLTFAYD VKESLKQKIT DIATKIYHAD GVEFTPSAAK QLQQLEELGF 490 500 510 520 530 540 GELPICMAKT QYSFTDDQTK LGAPENFRIT VREVRVSAGA GFVVCLTGSI MTMPGLPKVP 550 AAEHIDVLDD GRIVGLF

References

[1]

"Complete genome sequence of Atopobium parvulum type strain (IPP 1246)." Copeland A., Sikorski J., Lapidus A., Nolan M., Glavina Del Rio T., Lucas S., Chen F., Tice H., Pitluc S., Cheng J.F., Pukall R., Chertkov O., Brettin T., Han C., Detter J.C., Kuske C., Bruce D., Goodwin L. , Ivanova N., Mavromatis K., Mikhailova N., Chen A., Palaniappan K., Chain P., Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Detter J.C. Stand. Genomic Sci. 1:166-173(2009) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33793 / DSM 20469 / JCM 10300 / VPI 0546.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001721 Genomic DNA. Translation: ACV51051.1.
RefSeq	YP_003179642.1. NC_013203.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	521095.Apar_0621.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACV51051; ACV51051; Apar_0621.
GeneID	8413481.
KEGG	apv:Apar_0621.
PATRIC	21006723. VBIAtoPar109073_0601.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HOG000040280.
KO	K01938.
OMA	IIIGYNY.
ProtClustDB	CLSK2556717.
Enzyme and pathway databases
BioCyc	APAR521095:GH57-643-MONOMER.
UniPathway	UPA00193.
Family and domain databases
HAMAP	MF_01543. FTHFS.
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C8WAB3_ATOPD

Accession

Primary (citable) accession number: C8WAB3

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)