ID   C8W9G2_LANP1            Unreviewed;       333 AA.
AC   C8W9G2;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=D-alanine--D-alanine ligase {ECO:0000313|EMBL:ACV50750.1};
DE            EC=6.3.2.4 {ECO:0000313|EMBL:ACV50750.1};
GN   OrderedLocusNames=Apar_0319 {ECO:0000313|EMBL:ACV50750.1};
OS   Lancefieldella parvula (strain ATCC 33793 / DSM 20469 / CCUG 32760 / JCM
OS   10300 / KCTC 3663 / VPI 0546 / 1246) (Atopobium parvulum).
OC   Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC   Lancefieldella.
OX   NCBI_TaxID=521095 {ECO:0000313|EMBL:ACV50750.1, ECO:0000313|Proteomes:UP000000960};
RN   [1] {ECO:0000313|EMBL:ACV50750.1, ECO:0000313|Proteomes:UP000000960}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33793 / DSM 20469 / CCUG 32760 / JCM 10300 / KCTC 3663 /
RC   VPI 0546 / 1246 {ECO:0000313|Proteomes:UP000000960};
RX   PubMed=21304653; DOI=10.4056/sigs.29547;
RA   Copeland A., Sikorski J., Lapidus A., Nolan M., Del Rio T.G., Lucas S.,
RA   Chen F., Tice H., Pitluck S., Cheng J.F., Pukall R., Chertkov O.,
RA   Brettin T., Han C., Detter J.C., Kuske C., Bruce D., Goodwin L.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Chen A., Palaniappan K.,
RA   Chain P., Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Kyrpides N.C., Klenk H.P., Detter J.C.;
RT   "Complete genome sequence of Atopobium parvulum type strain (IPP 1246).";
RL   Stand. Genomic Sci. 1:166-173(2009).
CC   -!- SIMILARITY: Belongs to the D-alanine--D-alanine ligase family.
CC       {ECO:0000256|ARBA:ARBA00010871}.
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DR   EMBL; CP001721; ACV50750.1; -; Genomic_DNA.
DR   RefSeq; WP_012808408.1; NC_013203.1.
DR   AlphaFoldDB; C8W9G2; -.
DR   STRING; 521095.Apar_0319; -.
DR   GeneID; 84805851; -.
DR   KEGG; apv:Apar_0319; -.
DR   eggNOG; COG1181; Bacteria.
DR   HOGENOM; CLU_039268_1_0_11; -.
DR   OrthoDB; 9813261at2; -.
DR   Proteomes; UP000000960; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008716; F:D-alanine-D-alanine ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.20; -; 1.
DR   Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR000291; D-Ala_lig_Van_CS.
DR   InterPro; IPR011095; Dala_Dala_lig_C.
DR   InterPro; IPR011127; Dala_Dala_lig_N.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   PANTHER; PTHR23132; D-ALANINE--D-ALANINE LIGASE; 1.
DR   PANTHER; PTHR23132:SF0; D-ALANINE-D-ALANINE LIGASE FAMILY; 1.
DR   Pfam; PF07478; Dala_Dala_lig_C; 1.
DR   Pfam; PF01820; Dala_Dala_lig_N; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00843; DALA_DALA_LIGASE_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00409}; Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW   Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACV50750.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00409}; Peptidoglycan synthesis {ECO:0000256|ARBA:ARBA00022984};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000960}.
FT   DOMAIN          120..326
FT                   /note="ATP-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS50975"
SQ   SEQUENCE   333 AA;  35252 MW;  8F58F0D102398546 CRC64;
     MATKVAVIMG GASFERNFSL KSGALVSEAL EKCGYEVLPL DADAHLVDTL RAEKPDVAFV
     CLHGAGGEDG AVPALLEFLK IPYVGSRPAS CRAAWNKADM PFIVRQAWSK EESEVIWPPQ
     IVLTASAFKD LGAAAALDMV PERLGGGVGF PLAVKPVHGG SAMGLSKVDS ADQLGKALLG
     ALGFDDSVII QQWVDGVEVS VTVLSDADGE KTLPPVEISV IKGIYDTDAR LDPERIEHFC
     PVRSESLAAL GADPVAAREA LERAALEVFT AYGCRDLARI DFIWDGHHVM VMGLKTFPGL
     TETSLVPMAI EAAGYAVEDV LAQLVEGALK RGN
//