C8W9G2 (C8W9G2_ATOPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
D-alanine--D-alanine ligase EMBL ACV50750.1
EC=6.3.2.4 EMBL ACV50750.1

Gene names

Ordered Locus Names:

Apar_0319

Organism

Atopobium parvulum (strain ATCC 33793 / DSM 20469 / JCM 10300 / VPI 0546) (Streptococcus parvulus) (Peptostreptococcus parvulus) [Complete proteome] [HAMAP]

Taxonomic identifier

521095 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Coriobacteridae › Coriobacteriales › Coriobacterineae › Coriobacteriaceae › Atopobium › Atopobium parvulum

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation By similarity. SAAS SAAS005905
Catalytic activity	ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. SAAS SAAS005905
Cofactor	Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS005905
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. SAAS SAAS005905
Subcellular location	Cytoplasm By similarity SAAS SAAS005905.
Sequence similarities	Contains 1 ATP-grasp domain. SAAS SAAS005905

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation SAAS SAAS005905 Peptidoglycan synthesis SAAS SAAS005905
Cellular component	Cytoplasm SAAS SAAS005905
Ligand	ATP-binding SAAS SAAS005905 Magnesium SAAS SAAS005905 Manganese SAAS SAAS005905 Metal-binding SAAS SAAS005905 Nucleotide-binding
Molecular function	Ligase SAAS SAAS005905 EMBL ACV50750.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell wall Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW D-alanine-D-alanine ligase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C8W9G2 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: 8F58F0D102398546	FASTA	333	35,252
	10 20 30 40 50 60 MATKVAVIMG GASFERNFSL KSGALVSEAL EKCGYEVLPL DADAHLVDTL RAEKPDVAFV 70 80 90 100 110 120 CLHGAGGEDG AVPALLEFLK IPYVGSRPAS CRAAWNKADM PFIVRQAWSK EESEVIWPPQ 130 140 150 160 170 180 IVLTASAFKD LGAAAALDMV PERLGGGVGF PLAVKPVHGG SAMGLSKVDS ADQLGKALLG 190 200 210 220 230 240 ALGFDDSVII QQWVDGVEVS VTVLSDADGE KTLPPVEISV IKGIYDTDAR LDPERIEHFC 250 260 270 280 290 300 PVRSESLAAL GADPVAAREA LERAALEVFT AYGCRDLARI DFIWDGHHVM VMGLKTFPGL 310 320 330 TETSLVPMAI EAAGYAVEDV LAQLVEGALK RGN

References

[1]

"Complete genome sequence of Atopobium parvulum type strain (IPP 1246)." Copeland A., Sikorski J., Lapidus A., Nolan M., Glavina Del Rio T., Lucas S., Chen F., Tice H., Pitluc S., Cheng J.F., Pukall R., Chertkov O., Brettin T., Han C., Detter J.C., Kuske C., Bruce D., Goodwin L. , Ivanova N., Mavromatis K., Mikhailova N., Chen A., Palaniappan K., Chain P., Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Detter J.C. Stand. Genomic Sci. 1:166-173(2009) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33793 / DSM 20469 / JCM 10300 / VPI 0546.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001721 Genomic DNA. Translation: ACV50750.1.
RefSeq	YP_003179341.1. NC_013203.1.
3D structure databases
ProteinModelPortal	C8W9G2.
ModBase	Search...
Protein-protein interaction databases
STRING	521095.Apar_0319.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACV50750; ACV50750; Apar_0319.
GeneID	8413167.
KEGG	apv:Apar_0319.
PATRIC	21006125. VBIAtoPar109073_0313.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1181.
HOGENOM	HOG000011592.
KO	K01921.
OMA	MGGASFE.
ProtClustDB	CLSK2555336.
Enzyme and pathway databases
BioCyc	APAR521095:GH57-329-MONOMER.
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.30.1490.20. 1 hit. 3.30.470.20. 2 hits. 3.40.50.20. 1 hit.
InterPro	IPR011761. ATP-grasp. IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR000291. D-Ala_lig_Van_CS. IPR005905. D_ala_D_ala. IPR011095. Dala_Dala_lig_C. IPR011127. Dala_Dala_lig_N. IPR016185. PreATP-grasp_dom. [Graphical view]
PANTHER	PTHR23132. PTHR23132. 1 hit.
Pfam	PF07478. Dala_Dala_lig_C. 1 hit. PF01820. Dala_Dala_lig_N. 2 hits. [Graphical view]
SUPFAM	SSF52440. PreATP-grasp-like. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. PS00843. DALA_DALA_LIGASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C8W9G2_ATOPD

Accession

Primary (citable) accession number: C8W9G2

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)