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C8W8J3 (C8W8J3_ATOPD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Apar_1360
OrganismAtopobium parvulum (strain ATCC 33793 / DSM 20469 / JCM 10300 / VPI 0546) (Streptococcus parvulus) (Peptostreptococcus parvulus) [Complete proteome] [HAMAP]
Taxonomic identifier521095 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Coriobacteridae › Coriobacteriales › Coriobacterineae › Coriobacteriaceae › Atopobium ›

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047 SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain109 – 312204ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding140 – 19556ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2661Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2791Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2791Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2811Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C8W8J3 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: CE4446E8B45FF41D

FASTA31934,579
        10         20         30         40         50         60 
MTREELKKLH VAVVSGGWSD EHEIAMESGK QCAAALKEAG FINVDLLDVA EKDFVVALAQ 

        70         80         90        100        110        120 
GDYDVVYVAM HGRFGEDGCI QGLLEILHIP YTFSGVLASA MGTEKELSKL MYRQAGIPTP 

       130        140        150        160        170        180 
RGIDVPSGTV FTDEQVDKLI EDLGFPMFVK PSGNGSSYGV TRVTSREELP AALKLAGEQG 

       190        200        210        220        230        240 
ERILIEECVV GTEITVPVIG NDNPTALPIV EIVTGDEFYS IKTKYEPASL HHVIPARLEP 

       250        260        270        280        290        300 
AVYARAQELA IKAHNALGCR GVSRSDFIVT EDGEPVVLET NTIPGMTARS LLPDSARTGG 

       310 
IDFPELCTRF IEFALEDRQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001721 Genomic DNA. Translation: ACV51784.1.
RefSeqYP_003180375.1. NC_013203.1.

3D structure databases

ProteinModelPortalC8W8J3.
ModBaseSearch...

Protein-protein interaction databases

STRING521095.Apar_1360.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV51784; ACV51784; Apar_1360.
GeneID8414251.
KEGGapv:Apar_1360.
PATRIC21008215. VBIAtoPar109073_1320.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAVEDASCD.
ProtClustDBCLSK2820901.

Enzyme and pathway databases

BioCycAPAR521095:GH57-1413-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC8W8J3_ATOPD
AccessionPrimary (citable) accession number: C8W8J3
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info