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Protein
Submitted name:

Peptidoglycan glycosyltransferase

Gene

Apar_1344

Organism
Atopobium parvulum (strain ATCC 33793 / DSM 20469 / JCM 10300 / VPI 0546) (Streptococcus parvulus) (Peptostreptococcus parvulus)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciAPAR521095:GH57-1394-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Peptidoglycan glycosyltransferaseImported (EC:2.4.1.129Imported)
Gene namesi
Ordered Locus Names:Apar_1344Imported
OrganismiAtopobium parvulum (strain ATCC 33793 / DSM 20469 / JCM 10300 / VPI 0546) (Streptococcus parvulus) (Peptostreptococcus parvulus)Imported
Taxonomic identifieri521095 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCoriobacteriiaCoriobacterialesAtopobiaceaeAtopobium
Proteomesi
  • UP000000960 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence analysisAdd
BLAST
Transmembranei44 – 6320HelicalSequence analysisAdd
BLAST
Transmembranei70 – 8718HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11422HelicalSequence analysisAdd
BLAST
Transmembranei126 – 14419HelicalSequence analysisAdd
BLAST
Transmembranei164 – 18017HelicalSequence analysisAdd
BLAST
Transmembranei200 – 21920HelicalSequence analysisAdd
BLAST
Transmembranei225 – 24117HelicalSequence analysisAdd
BLAST
Transmembranei246 – 26520HelicalSequence analysisAdd
BLAST
Transmembranei330 – 35122HelicalSequence analysisAdd
BLAST
Transmembranei363 – 38422HelicalSequence analysisAdd
BLAST
Transmembranei396 – 41520HelicalSequence analysisAdd
BLAST
Transmembranei484 – 50522HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi521095.Apar_1344.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JBFX-ray1.92A/B505-954[»]
4N1XX-ray2.00A/B515-954[»]
4QJGX-ray1.85A/B505-954[»]
4R0QX-ray2.00A/B505-954[»]
4R1GX-ray1.92A/B505-954[»]
4R23X-ray1.84A/B505-954[»]
4R3JX-ray2.44A/B505-954[»]
4RA7X-ray1.94A/B505-954[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini631 – 941311TranspeptidaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SEDS family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QHZ. Bacteria.
COG0768. LUCA.
COG0772. LUCA.
HOGENOMiHOG000101245.
KOiK05364.
OMAiNAWFSAV.
OrthoDBiEOG6N0HHV.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001182. Cell_cycle_FtsW/RodA.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PANTHERiPTHR30474. PTHR30474. 1 hit.
PfamiPF01098. FTSW_RODA_SPOVE. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 2 hits.

Sequencei

Sequence statusi: Complete.

C8W8H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKAGGLRRN TELFLLFVGA IPVFLLYAMY MITARSTLSV ETMAVPIGLF
60 70 80 90 100
AAFTVAHIAI RFLAPAADPA ILPIVFVLSG IGITMVTRLS PNLAVNQTIW
110 120 130 140 150
LFISVVVMIV VLAIIRNLDA LADYKYSIGI LGVILLLLPI VIGQDRYGSR
160 170 180 190 200
LWISFGPFTF QPGEIAKIAI TLFLAFYLAL NREALSVSMR SVGPFRIPRF
210 220 230 240 250
KMLLPLFVMW GISLIVVIFE RDLGSALLFF VFFVIMLYVA TGRASYVFVS
260 270 280 290 300
VALLAIGGVI LYHFFSHVQT RVNIWLDPFK DPSGDGFQIV QSLYSIADGG
310 320 330 340 350
LAGTGIDKGM PTLIPVVESD FIFSAIAEEM GLFGGAAIIT LFLLLTVRGL
360 370 380 390 400
ATAARAKSDS SAFAAAGLTS VLAFQTFLII AGVTKLMPLT GVTLPFMSQG
410 420 430 440 450
GSSLLSSFII VALLLRAGDE GTGRETELEP SKKVLDSQRL EISSGGAHAS
460 470 480 490 500
SVLHGSHIRG GFDLQSEESG VLGRVALGKR LTNLVTVFTL FFTVLLGNLT
510 520 530 540 550
FLMVIDAPRL QALPTNNHTI AKSAYVQRGA IITSDGVTLA ESVKQDDGTY
560 570 580 590 600
VRNYPHDGMA SHTVGYISTQ YGTAGIESSM NETLTGHADH SDWRSALYSM
610 620 630 640 650
AGINTTGSSV VLTINSQMQA VAEAALQGYS GSIVVMDPST GAVLAKASSP
660 670 680 690 700
SYTHAELGTI IESGTGSQLV DRTTQALYSP GSSFKTVTLA AGIDTHKTTL
710 720 730 740 750
DTTYSAPGTM EIGGGTIHNY ANEDMGTIPL REAFARSSNT ALAQLGVALG
760 770 780 790 800
ADNLVSYARA FGYGTALGQD FSTTPSLMPN PAEMTTWELA WASCGLPVGE
810 820 830 840 850
HASPAGPQTT VMQNAVIAAA IANGGVVMNP YIVDRVLSPE GAVVSTTSPK
860 870 880 890 900
SLGQAVSADT AAQVREAMLG VVESGTGMGA RVPGVKIAGK TGTADVENGN
910 920 930 940 950
FNSFFIGFAP YDHPTLVVSV VIEGNGENVL GYGAQVGGRV LAQCLNIQAL

GAAS
Length:954
Mass (Da):100,455
Last modified:November 3, 2009 - v1
Checksum:i5E92680037B72EBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001721 Genomic DNA. Translation: ACV51768.1.
RefSeqiWP_012809424.1. NC_013203.1.

Genome annotation databases

EnsemblBacteriaiACV51768; ACV51768; Apar_1344.
KEGGiapv:Apar_1344.
PATRICi21008179. VBIAtoPar109073_1305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001721 Genomic DNA. Translation: ACV51768.1.
RefSeqiWP_012809424.1. NC_013203.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JBFX-ray1.92A/B505-954[»]
4N1XX-ray2.00A/B515-954[»]
4QJGX-ray1.85A/B505-954[»]
4R0QX-ray2.00A/B505-954[»]
4R1GX-ray1.92A/B505-954[»]
4R23X-ray1.84A/B505-954[»]
4R3JX-ray2.44A/B505-954[»]
4RA7X-ray1.94A/B505-954[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi521095.Apar_1344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV51768; ACV51768; Apar_1344.
KEGGiapv:Apar_1344.
PATRICi21008179. VBIAtoPar109073_1305.

Phylogenomic databases

eggNOGiENOG4107QHZ. Bacteria.
COG0768. LUCA.
COG0772. LUCA.
HOGENOMiHOG000101245.
KOiK05364.
OMAiNAWFSAV.
OrthoDBiEOG6N0HHV.

Enzyme and pathway databases

BioCyciAPAR521095:GH57-1394-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001182. Cell_cycle_FtsW/RodA.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PANTHERiPTHR30474. PTHR30474. 1 hit.
PfamiPF01098. FTSW_RODA_SPOVE. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33793 / DSM 20469 / JCM 10300 / VPI 0546Imported.
  2. "Crystal structure of peptidoglycan glycosyltransferase from Atopobium parvulum DSM 20469."
    Midwest Center For Structural Genomics (MCSG)
    Filippova E.V., Wawrzak Z., Minasov G., Shuvalova L., Kiryukhina O., Babnigg G., Rubin E., Sacchettini J., Joachimiak A., Anderson W.F.
    Submitted (FEB-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 505-954.
  3. "Structure of a putative peptidoglycan glycosyltransferase from Atopobium parvulum in complex with penicillin G."
    Filippova E.V., Minasov G., Shuvalova L., Kiryukhina O., Babnigg G., Rubin E., Sacchettini J., Joachimiak A., Anderson W.F.
    Submitted (OCT-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 515-954.
  4. "Structure of a putative peptidoglycan glycosyltransferase from Atopobium parvulum in complex with penicillin V."
    Midwest Center For Structural Genomics (MCSG)
    Filippova E.V., Minasov G., Kiryukhina O., Clancy S., Joachimiak A., Anderson W.F.
    Submitted (JUN-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 505-954.
  5. "Structure of a putative peptidoglycan glycosyltransferase from Atopobium parvulum in complex with cefapirin."
    Filippova E.V., Minasov G., Kiryukhina O., Clancy S., Joachimiak A., Anderson W.F.
    Submitted (AUG-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 505-954.
  6. "Structure of a putative peptidoglycan glycosyltransferase from Atopobium parvulum in complex with cephalothin."
    Filippova E.V., Minasov G., Kiryukhina O., Clancy S., Joachimiak A., Anderson W.F.
    Submitted (AUG-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 505-954.
  7. "Structure of a putative peptidoglycan glycosyltransferase from Atopobium parvulum in complex with cloxacillin."
    Filippova E.V., Minasov G., Kiryukhina O., Clancy S., Joachimiak A., Anderson W.F.
    Submitted (AUG-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 505-954.
  8. "Structure of a putative peptidoglycan glycosyltransferase from Atopobium parvulum in complex with dicloxacillin."
    Filippova E.V., Minasov G., Kiryukhina O., Clancy S., Joachimiak A., Anderson W.F.
    Submitted (AUG-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 505-954.
  9. "Structure of a putative peptidoglycan glycosyltransferase from Atopobium parvulum in complex with nafcillin."
    Filippova E.V., Minasov G., Kiryukhina O., Clancy S., Joachimiak A., Anderson W.F.
    Submitted (SEP-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) OF 505-954.

Entry informationi

Entry nameiC8W8H7_ATOPD
AccessioniPrimary (citable) accession number: C8W8H7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: May 11, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.