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C8W5P2

- C8W5P2_DESAS

UniProt

C8W5P2 - C8W5P2_DESAS

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Protein
Glutamate 5-kinase
Gene
proB, Dtox_3311
Organism
Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151ATP By similarityUniRule annotation
Binding sitei55 – 551Substrate By similarityUniRule annotation
Binding sitei142 – 1421Substrate By similarityUniRule annotation
Binding sitei154 – 1541Substrate; via amide nitrogen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 1752ATP By similarityUniRule annotation
Nucleotide bindingi216 – 2227ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. glutamate 5-kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciDACE485916:GHUF-3386-MONOMER.
UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
Alternative name(s):
Gamma-glutamyl kinase
Gene namesi
Name:proBUniRule annotation
Ordered Locus Names:Dtox_3311Imported
OrganismiDesulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)Imported
Taxonomic identifieri485916 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
ProteomesiUP000002217: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Protein-protein interaction databases

STRINGi485916.Dtox_3311.

Structurei

3D structure databases

ProteinModelPortaliC8W5P2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini280 – 35879PUA By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Belongs to the glutamate 5-kinase family.UniRule annotation
Contains 1 PUA domain.UniRule annotation
Contains PUA domain.SAAS annotations

Phylogenomic databases

eggNOGiCOG0263.
HOGENOMiHOG000246369.
KOiK00931.
OMAiRLMRAYE.
OrthoDBiEOG6PGK7G.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.
PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8W5P2-1 [UniParc]FASTAAdd to Basket

« Hide

MKNRDFSRVK RLVVKVGSSS LAHATGKLNL YQFEQLAVQL ADLHNQGKEI    50
LLVTSGAVGA GLGKLGLRRR PKTMPEKQAA AAVGQGVLMQ MYEKFFAEYG 100
VTVGQVLLSR EDFSDRRRFL NARNTMYALL GMGVIPIINE NDTVSIEEIR 150
LGDNDTLSAL VTGLVDAELL VLLSDIDGVY TADPRKDPAA VIISEIDEIN 200
EQVESLAGGA GSGLGTGGMT TKLQAAKIAM RSGAAMVIAR AAEKNIIRRV 250
VTGEPLGTVF CPGNKLDNKK HWIMYSSAVQ GKISIDEGAS RALVKNGKSL 300
LPSGVVKVEG VFEMGNTVCI SGPDGRQIAR GITNYAAEEL KKIMGKKTSE 350
IAVVLGSKDY DEVIHRNNLV LDC 373
Length:373
Mass (Da):40,031
Last modified:November 3, 2009 - v1
Checksum:i1C5C85B12B66C744
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001720 Genomic DNA. Translation: ACV64042.1.
RefSeqiWP_015758732.1. NC_013216.1.
YP_003192665.1. NC_013216.1.

Genome annotation databases

EnsemblBacteriaiACV64042; ACV64042; Dtox_3311.
GeneIDi8430305.
KEGGidae:Dtox_3311.
PATRICi21723531. VBIDesAce42372_3366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001720 Genomic DNA. Translation: ACV64042.1 .
RefSeqi WP_015758732.1. NC_013216.1.
YP_003192665.1. NC_013216.1.

3D structure databases

ProteinModelPortali C8W5P2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 485916.Dtox_3311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACV64042 ; ACV64042 ; Dtox_3311 .
GeneIDi 8430305.
KEGGi dae:Dtox_3311.
PATRICi 21723531. VBIDesAce42372_3366.

Phylogenomic databases

eggNOGi COG0263.
HOGENOMi HOG000246369.
KOi K00931.
OMAi RLMRAYE.
OrthoDBi EOG6PGK7G.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .
BioCyci DACE485916:GHUF-3386-MONOMER.

Family and domain databases

Gene3Di 2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SMARTi SM00359. PUA. 1 hit.
[Graphical view ]
SUPFAMi SSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49208 / DSM 771 / VKM B-1644.

Entry informationi

Entry nameiC8W5P2_DESAS
AccessioniPrimary (citable) accession number: C8W5P2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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