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C8W5P2 (C8W5P2_DESAS) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamate 5-kinase HAMAP-Rule MF_00456

EC=2.7.2.11 HAMAP-Rule MF_00456
Alternative name(s):
Gamma-glutamyl kinase HAMAP-Rule MF_00456
Gene names
Name:proB HAMAP-Rule MF_00456
Ordered Locus Names:Dtox_3311 EMBL ACV64042.1
OrganismDesulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644) [Complete proteome] [HAMAP] EMBL ACV64042.1
Taxonomic identifier485916 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline By similarity. HAMAP-Rule MF_00456 SAAS SAAS019797

Catalytic activity

ATP + L-glutamate = ADP + L-glutamate 5-phosphate. HAMAP-Rule MF_00456 SAAS SAAS019797

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. HAMAP-Rule MF_00456 SAAS SAAS019797

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00456 SAAS SAAS019797.

Sequence similarities

Belongs to the glutamate 5-kinase family. HAMAP-Rule MF_00456

Contains 1 PUA domain. HAMAP-Rule MF_00456

Contains PUA domain. SAAS SAAS019797

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain280 – 35879PUA By similarity HAMAP-Rule MF_00456
Nucleotide binding174 – 1752ATP By similarity HAMAP-Rule MF_00456
Nucleotide binding216 – 2227ATP By similarity HAMAP-Rule MF_00456

Sites

Binding site151ATP By similarity HAMAP-Rule MF_00456
Binding site551Substrate By similarity HAMAP-Rule MF_00456
Binding site1421Substrate By similarity HAMAP-Rule MF_00456
Binding site1541Substrate; via amide nitrogen By similarity HAMAP-Rule MF_00456

Sequences

Sequence LengthMass (Da)Tools
C8W5P2 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: 1C5C85B12B66C744

FASTA37340,031
        10         20         30         40         50         60 
MKNRDFSRVK RLVVKVGSSS LAHATGKLNL YQFEQLAVQL ADLHNQGKEI LLVTSGAVGA 

        70         80         90        100        110        120 
GLGKLGLRRR PKTMPEKQAA AAVGQGVLMQ MYEKFFAEYG VTVGQVLLSR EDFSDRRRFL 

       130        140        150        160        170        180 
NARNTMYALL GMGVIPIINE NDTVSIEEIR LGDNDTLSAL VTGLVDAELL VLLSDIDGVY 

       190        200        210        220        230        240 
TADPRKDPAA VIISEIDEIN EQVESLAGGA GSGLGTGGMT TKLQAAKIAM RSGAAMVIAR 

       250        260        270        280        290        300 
AAEKNIIRRV VTGEPLGTVF CPGNKLDNKK HWIMYSSAVQ GKISIDEGAS RALVKNGKSL 

       310        320        330        340        350        360 
LPSGVVKVEG VFEMGNTVCI SGPDGRQIAR GITNYAAEEL KKIMGKKTSE IAVVLGSKDY 

       370 
DEVIHRNNLV LDC 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001720 Genomic DNA. Translation: ACV64042.1.
RefSeqYP_003192665.1. NC_013216.1.

3D structure databases

ProteinModelPortalC8W5P2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING485916.Dtox_3311.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV64042; ACV64042; Dtox_3311.
GeneID8430305.
KEGGdae:Dtox_3311.
PATRIC21723531. VBIDesAce42372_3366.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0263.
HOGENOMHOG000246369.
KOK00931.
OMARLMRAYE.
OrthoDBEOG6PGK7G.

Enzyme and pathway databases

BioCycDACE485916:GHUF-3386-MONOMER.
UniPathwayUPA00098; UER00359.

Family and domain databases

Gene3D2.30.130.10. 1 hit.
3.40.1160.10. 1 hit.
HAMAPMF_00456. ProB.
InterProIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
PfamPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFPIRSF000729. GK. 1 hit.
PRINTSPR00474. GLU5KINASE.
SMARTSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMSSF53633. SSF53633. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsTIGR01027. proB. 1 hit.
PROSITEPS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC8W5P2_DESAS
AccessionPrimary (citable) accession number: C8W5P2
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)