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C8VZ65 (C8VZ65_DESAS) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Dtox_2148 EMBL ACV62975.1
OrganismDesulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644) [Complete proteome] [HAMAP] EMBL ACV62975.1
Taxonomic identifier485916 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain101 – 307207ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding135 – 19056ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2611Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2741Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2741Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2761Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C8VZ65 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: 4ADD1CA8DFCDB5CA

FASTA31434,456
        10         20         30         40         50         60 
MIKKIGVLLG GKSAEREVSL RTGEAIYKAL LGLGYQVVKI DVQENIAERI KEESIDMAFL 

        70         80         90        100        110        120 
ALHGKYGEDG CIQGLLEILN IPYTGSGVLA SALAMDKIAT KRMLLQAKLP TAEFSLIRRS 

       130        140        150        160        170        180 
SYNNETKEEI CQTLFKYMPL PLVVKAPTQG STIGISFVNN EEQLPDALEE AFRYDPIALI 

       190        200        210        220        230        240 
EQFISGTEVT ATVLGNNQPE ALPLIEIVSN TGVYDYKAKY TVGLSDHIMP PRLKEEVQKN 

       250        260        270        280        290        300 
VQELAVKVFK TMGCSGLARV DFIVDANSNP YILEINTIPG MTETSLAPDA ARAAGISFTD 

       310 
LTDRMIKFAL EKDD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001720 Genomic DNA. Translation: ACV62975.1.
RefSeqYP_003191598.1. NC_013216.1.

3D structure databases

ProteinModelPortalC8VZ65.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING485916.Dtox_2148.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV62975; ACV62975; Dtox_2148.
GeneID8429130.
KEGGdae:Dtox_2148.
PATRIC21721167. VBIDesAce42372_2194.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAANDTQYR.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycDACE485916:GHUF-2211-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC8VZ65_DESAS
AccessionPrimary (citable) accession number: C8VZ65
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)