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C8VZ34

- C8VZ34_DESAS

UniProt

C8VZ34 - C8VZ34_DESAS

Protein

Homoserine kinase

Gene

thrB

Organism
Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotationSAAS annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi86 – 9611ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. homoserine kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDACE485916:GHUF-2178-MONOMER.
    UniPathwayiUPA00050; UER00064.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
    Short name:
    HKUniRule annotation
    Short name:
    HSKUniRule annotation
    Gene namesi
    Name:thrBUniRule annotation
    Ordered Locus Names:Dtox_2115Imported
    OrganismiDesulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)Imported
    Taxonomic identifieri485916 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
    ProteomesiUP000002217: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi485916.Dtox_2115.

    Structurei

    3D structure databases

    ProteinModelPortaliC8VZ34.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0083.
    HOGENOMiHOG000247199.
    KOiK00872.
    OMAiMQDRLHQ.
    OrthoDBiEOG6DG2WK.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00384. Homoser_kinase.
    InterProiIPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR000870. Homoserine_kinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PfamiPF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000676. Homoser_kin. 1 hit.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00191. thrB. 1 hit.
    PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C8VZ34-1 [UniParc]FASTAAdd to Basket

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    MIRVKVPATV ANLGPGFDCL GMALEFYNAV EMYEIPSGLY IEVQGEGTEL    50
    IPKNEQNIVY QAARRVFQKV GYTPAGLKIK LTNNVPVGKG LGSSASAIVG 100
    GIIAANVMSG KQLKEKDLLS LAAEIEGHPD NVAPALLGGI IVSVSLEGDI 150
    KYIKITPPSQ LKCVVAVPDF CLSTKTSREA LPQQVSFNDA VFNIGRVALL 200
    VASLQQGELG LLSVAMDDRM HQSYRSGLIP GMKKVMAAAK LAGARGVTLS 250
    GAGPTLIAFA DNNMELISKV MKDTFRQNGI MAKVYILNPS PVGSMTLCCT 300
    Length:300
    Mass (Da):31,755
    Last modified:November 3, 2009 - v1
    Checksum:iA08FE66B92A0D710
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001720 Genomic DNA. Translation: ACV62944.1.
    RefSeqiYP_003191567.1. NC_013216.1.

    Genome annotation databases

    EnsemblBacteriaiACV62944; ACV62944; Dtox_2115.
    GeneIDi8429097.
    KEGGidae:Dtox_2115.
    PATRICi21721099. VBIDesAce42372_2160.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001720 Genomic DNA. Translation: ACV62944.1 .
    RefSeqi YP_003191567.1. NC_013216.1.

    3D structure databases

    ProteinModelPortali C8VZ34.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 485916.Dtox_2115.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACV62944 ; ACV62944 ; Dtox_2115 .
    GeneIDi 8429097.
    KEGGi dae:Dtox_2115.
    PATRICi 21721099. VBIDesAce42372_2160.

    Phylogenomic databases

    eggNOGi COG0083.
    HOGENOMi HOG000247199.
    KOi K00872.
    OMAi MQDRLHQ.
    OrthoDBi EOG6DG2WK.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00064 .
    BioCyci DACE485916:GHUF-2178-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00384. Homoser_kinase.
    InterProi IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR000870. Homoserine_kinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    Pfami PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000676. Homoser_kin. 1 hit.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00191. thrB. 1 hit.
    PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49208 / DSM 771 / VKM B-1644Imported.

    Entry informationi

    Entry nameiC8VZ34_DESAS
    AccessioniPrimary (citable) accession number: C8VZ34
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3