UniProtKB - C8VZ34 (C8VZ34_DESAS)
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Protein
Homoserine kinase
Gene
thrB
Organism
Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)
Status
Functioni
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotationSAAS annotation
Catalytic activityi
ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotationSAAS annotation
: L-threonine biosynthesis Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotationSAAS annotationProteins known to be involved in the 5 steps of the subpathway in this organism are:
- Aspartokinase (Dtox_3165), Aspartokinase (Dtox_2117)
- Aspartate-semialdehyde dehydrogenase (asd)
- Homoserine dehydrogenase (Dtox_2114)
- Homoserine kinase (thrB)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 86 – 96 | ATPUniRule annotationAdd BLAST | 11 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- homoserine kinase activity Source: UniProtKB-UniRule
GO - Biological processi
- threonine biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | KinaseUniRule annotationSAAS annotationImported, Transferase |
Biological process | Amino-acid biosynthesis, Threonine biosynthesisUniRule annotationSAAS annotation |
Ligand | ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | DACE485916:G1GFV-2117-MONOMER. |
UniPathwayi | UPA00050; UER00064. |
Names & Taxonomyi
Protein namesi | Recommended name: Homoserine kinaseUniRule annotationSAAS annotation (EC:2.7.1.39UniRule annotationSAAS annotation)Short name: HKUniRule annotation Short name: HSKUniRule annotation |
Gene namesi | Name:thrBUniRule annotation Ordered Locus Names:Dtox_2115Imported |
Organismi | Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)Imported |
Taxonomic identifieri | 485916 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfotomaculum › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotationSAAS annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationSAAS annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 139 | GHMP_kinases_NInterPro annotationAdd BLAST | 62 | |
Domaini | 204 – 264 | GHMP_kinases_CInterPro annotationAdd BLAST | 61 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4105D5I. Bacteria. COG0083. LUCA. |
HOGENOMi | HOG000247199. |
KOi | K00872. |
OMAi | PDNVAPC. |
OrthoDBi | POG091H020X. |
Family and domain databases
Gene3Di | 3.30.230.10. 1 hit. 3.30.70.890. 1 hit. |
HAMAPi | MF_00384. Homoser_kinase. 1 hit. |
InterProi | View protein in InterPro IPR013750. GHMP_kinase_C_dom. IPR036554. GHMP_kinase_C_sf. IPR006204. GHMP_kinase_N_dom. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. |
PANTHERi | PTHR20861:SF1. PTHR20861:SF1. 1 hit. |
Pfami | View protein in Pfam PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. |
PIRSFi | PIRSF000676. Homoser_kin. 1 hit. |
SUPFAMi | SSF54211. SSF54211. 1 hit. SSF55060. SSF55060. 1 hit. |
TIGRFAMsi | TIGR00191. thrB. 1 hit. |
PROSITEi | View protein in PROSITE PS00627. GHMP_KINASES_ATP. 1 hit. |
i Sequence
Sequence statusi: Complete.
C8VZ34-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIRVKVPATV ANLGPGFDCL GMALEFYNAV EMYEIPSGLY IEVQGEGTEL
60 70 80 90 100
IPKNEQNIVY QAARRVFQKV GYTPAGLKIK LTNNVPVGKG LGSSASAIVG
110 120 130 140 150
GIIAANVMSG KQLKEKDLLS LAAEIEGHPD NVAPALLGGI IVSVSLEGDI
160 170 180 190 200
KYIKITPPSQ LKCVVAVPDF CLSTKTSREA LPQQVSFNDA VFNIGRVALL
210 220 230 240 250
VASLQQGELG LLSVAMDDRM HQSYRSGLIP GMKKVMAAAK LAGARGVTLS
260 270 280 290 300
GAGPTLIAFA DNNMELISKV MKDTFRQNGI MAKVYILNPS PVGSMTLCCT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001720 Genomic DNA. Translation: ACV62944.1. |
RefSeqi | WP_015757648.1. NC_013216.1. |
Genome annotation databases
EnsemblBacteriai | ACV62944; ACV62944; Dtox_2115. |
KEGGi | dae:Dtox_2115. |
Similar proteinsi
Entry informationi
Entry namei | C8VZ34_DESAS | |
Accessioni | C8VZ34Primary (citable) accession number: C8VZ34 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 3, 2009 |
Last sequence update: | November 3, 2009 | |
Last modified: | February 28, 2018 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |