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C8VZ34 (C8VZ34_DESAS) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Homoserine kinase HAMAP-Rule MF_00384
Short name=HK HAMAP-Rule MF_00384
Short name=HSK HAMAP-Rule MF_00384
EC=2.7.1.39 HAMAP-Rule MF_00384
Gene names
Name:thrB HAMAP-Rule MF_00384
Ordered Locus Names:Dtox_2115 EMBL ACV62944.1
OrganismDesulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644) [Complete proteome] [HAMAP] EMBL ACV62944.1
Taxonomic identifier485916 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfotomaculum ›

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP-Rule MF_00384 SAAS SAAS006203

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00384 SAAS SAAS006203

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00384 SAAS SAAS006203

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00384 SAAS SAAS006203.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP-Rule MF_00384

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding86 – 9611ATP By similarity HAMAP-Rule MF_00384

Sequences

Sequence LengthMass (Da)Tools
C8VZ34 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: A08FE66B92A0D710

FASTA30031,755
        10         20         30         40         50         60 
MIRVKVPATV ANLGPGFDCL GMALEFYNAV EMYEIPSGLY IEVQGEGTEL IPKNEQNIVY 

        70         80         90        100        110        120 
QAARRVFQKV GYTPAGLKIK LTNNVPVGKG LGSSASAIVG GIIAANVMSG KQLKEKDLLS 

       130        140        150        160        170        180 
LAAEIEGHPD NVAPALLGGI IVSVSLEGDI KYIKITPPSQ LKCVVAVPDF CLSTKTSREA 

       190        200        210        220        230        240 
LPQQVSFNDA VFNIGRVALL VASLQQGELG LLSVAMDDRM HQSYRSGLIP GMKKVMAAAK 

       250        260        270        280        290        300 
LAGARGVTLS GAGPTLIAFA DNNMELISKV MKDTFRQNGI MAKVYILNPS PVGSMTLCCT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001720 Genomic DNA. Translation: ACV62944.1.
RefSeqYP_003191567.1. NC_013216.1.

3D structure databases

ProteinModelPortalC8VZ34.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING485916.Dtox_2115.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV62944; ACV62944; Dtox_2115.
GeneID8429097.
KEGGdae:Dtox_2115.
PATRIC21721099. VBIDesAce42372_2160.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
HOGENOMHOG000247199.
KOK00872.
OMALHEPYRW.
OrthoDBEOG6DG2WK.
ProtClustDBCLSK853519.

Enzyme and pathway databases

BioCycDACE485916:GHUF-2178-MONOMER.
UniPathwayUPA00050; UER00064.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00384. Homoser_kinase.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
SUPFAMSSF54211. SSF54211. 1 hit.
TIGRFAMsTIGR00191. thrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC8VZ34_DESAS
AccessionPrimary (citable) accession number: C8VZ34
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info