C8VZ34 (C8VZ34_DESAS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Homoserine kinase HAMAP-Rule MF_00384
Short name=HK HAMAP-Rule MF_00384
Short name=HSK HAMAP-Rule MF_00384
EC=2.7.1.39 HAMAP-Rule MF_00384

Gene names

Name:	thrB HAMAP-Rule MF_00384
Ordered Locus Names:	Dtox_2115

Organism

Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644) [Complete proteome] [HAMAP] EMBL ACV62944.1

Taxonomic identifier

485916 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfotomaculum › Desulfotomaculum acetoxidans

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP-Rule MF_00384 SAAS SAAS000870
Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00384 SAAS SAAS000870
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00384 SAAS SAAS000870
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00384 SAAS SAAS000870.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP-Rule MF_00384

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis HAMAP-Rule MF_00384 SAAS SAAS000870
Cellular component	Cytoplasm HAMAP-Rule MF_00384 SAAS SAAS000870
Ligand	ATP-binding HAMAP-Rule MF_00384 SAAS SAAS000870 RuleBase RU003563 Nucleotide-binding
Molecular function	Kinase HAMAP-Rule MF_00384 SAAS SAAS000870 RuleBase RU003563 EMBL ACV62944.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	86 – 96	11	ATP By similarity HAMAP-Rule MF_00384

Sequences

	Sequence		Length	Mass (Da)
	C8VZ34 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: A08FE66B92A0D710	FASTA	300	31,755
	10 20 30 40 50 60 MIRVKVPATV ANLGPGFDCL GMALEFYNAV EMYEIPSGLY IEVQGEGTEL IPKNEQNIVY 70 80 90 100 110 120 QAARRVFQKV GYTPAGLKIK LTNNVPVGKG LGSSASAIVG GIIAANVMSG KQLKEKDLLS 130 140 150 160 170 180 LAAEIEGHPD NVAPALLGGI IVSVSLEGDI KYIKITPPSQ LKCVVAVPDF CLSTKTSREA 190 200 210 220 230 240 LPQQVSFNDA VFNIGRVALL VASLQQGELG LLSVAMDDRM HQSYRSGLIP GMKKVMAAAK 250 260 270 280 290 300 LAGARGVTLS GAGPTLIAFA DNNMELISKV MKDTFRQNGI MAKVYILNPS PVGSMTLCCT

References

[1]

"Complete genome sequence of Desulfotomaculum acetoxidans type strain (5575)." Spring S., Lapidus A., Schroder M., Gleim D., Sims D., Meincke L., Glavina Del Rio T., Tice H., Copeland A., Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S., Ivanova N., Mavromatis K. , Mikhailova N., Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Chain P., Saunders E., Brettin T., Detter J.C., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Han C. Stand. Genomic Sci. 1:242-253(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49208 / DSM 771 / VKM B-1644.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001720 Genomic DNA. Translation: ACV62944.1.
RefSeq	YP_003191567.1. NC_013216.1.
3D structure databases
ProteinModelPortal	C8VZ34.
ModBase	Search...
Protein-protein interaction databases
STRING	485916.Dtox_2115.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACV62944; ACV62944; Dtox_2115.
GeneID	8429097.
KEGG	dae:Dtox_2115.
PATRIC	21721099. VBIDesAce42372_2160.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0083.
HOGENOM	HOG000247199.
KO	K00872.
OMA	LHEPYRW.
ProtClustDB	CLSK853519.
Enzyme and pathway databases
BioCyc	DACE485916:GHUF-2178-MONOMER.
UniPathway	UPA00050; UER00064.
Family and domain databases
Gene3D	3.30.230.10. 1 hit.
HAMAP	MF_00384. Homoser_kinase.
InterPro	IPR013750. GHMP_kinase_C_dom. IPR006204. GHMP_kinase_N_dom. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. thrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C8VZ34_DESAS

Accession

Primary (citable) accession number: C8VZ34

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)