thrB

Functionⁱ

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotationSAAS annotation

Catalytic activityⁱ

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotationSAAS annotation

Pathwayⁱ: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:

Aspartokinase (Dtox_3165), Aspartokinase (Dtox_2117)
Aspartate-semialdehyde dehydrogenase (asd)
Homoserine dehydrogenase (Dtox_2114)
Homoserine kinase (thrB)
no protein annotated in this organism

This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	86 – 96	ATPUniRule annotationAdd BLAST		11

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-UniRule
homoserine kinase activity Source: UniProtKB-UniRule

Complete GO annotation...

GO - Biological processⁱ

threonine biosynthetic process Source: UniProtKB-UniRule

Complete GO annotation...

Keywordsⁱ

Molecular function	KinaseUniRule annotationSAAS annotationImported, Transferase
Biological process	Amino-acid biosynthesis, Threonine biosynthesisUniRule annotationSAAS annotation
Ligand	ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00050; UER00064.

UniPathwayⁱ

UPA00050; UER00064.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homoserine kinaseUniRule annotationSAAS annotation (EC:2.7.1.39UniRule annotationSAAS annotation) Short name: HKUniRule annotation Short name: HSKUniRule annotation
Gene namesⁱ	Name:thrBUniRule annotation Ordered Locus Names:Dtox_2115Imported
Organismⁱ	Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)Imported
Taxonomic identifierⁱ	485916 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfotomaculum › Desulfotomaculum acetoxidans
Proteomesⁱ	UP000002217 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Automatic assertion according to rulesⁱ
- HAMAP-Rule:MF_00384
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00649240

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotationSAAS annotation

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	485916.Dtox_2115.

STRINGⁱ

485916.Dtox_2115.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	C8VZ34.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	78 – 139	GHMP_kinases_NInterPro annotationAdd BLAST		62
Domainⁱ	204 – 264	GHMP_kinases_CInterPro annotationAdd BLAST		61

Sequence similaritiesⁱ

Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105D5I. Bacteria. COG0083. LUCA.
HOGENOMⁱ	HOG000247199.
KEGG Orthology (KO) More...KOⁱ	K00872.
OMAⁱ	PDNVAPC.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H020X.

Family and domain databases

Gene3Dⁱ	3.30.230.10. 1 hit. 3.30.70.890. 1 hit.
HAMAPⁱ	MF_00384. Homoser_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR013750. GHMP_kinase_C_dom. IPR006204. GHMP_kinase_N_dom. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PANTHERⁱ	PTHR20861:SF8. PTHR20861:SF8. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit.
PIRSFⁱ	PIRSF000676. Homoser_kin. 1 hit.
SUPFAMⁱ	SSF54211. SSF54211. 1 hit. SSF55060. SSF55060. 1 hit.
TIGRFAMsⁱ	TIGR00191. thrB. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00627. GHMP_KINASES_ATP. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

C8VZ34-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIRVKVPATV ANLGPGFDCL GMALEFYNAV EMYEIPSGLY IEVQGEGTEL 
        60         70         80         90        100
IPKNEQNIVY QAARRVFQKV GYTPAGLKIK LTNNVPVGKG LGSSASAIVG 
       110        120        130        140        150
GIIAANVMSG KQLKEKDLLS LAAEIEGHPD NVAPALLGGI IVSVSLEGDI 
       160        170        180        190        200
KYIKITPPSQ LKCVVAVPDF CLSTKTSREA LPQQVSFNDA VFNIGRVALL 
       210        220        230        240        250
VASLQQGELG LLSVAMDDRM HQSYRSGLIP GMKKVMAAAK LAGARGVTLS 
       260        270        280        290        300
GAGPTLIAFA DNNMELISKV MKDTFRQNGI MAKVYILNPS PVGSMTLCCT

Length:300

Mass (Da):31,755

Last modified:November 3, 2009 - v1

Checksum:ⁱA08FE66B92A0D710

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001720 Genomic DNA. Translation: ACV62944.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_015757648.1. NC_013216.1.

Genome annotation databases

EnsemblBacteriaⁱ	ACV62944; ACV62944; Dtox_2115.
KEGGⁱ	dae:Dtox_2115.

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
C8VZ34	UPI00048A01E7 R4KFH9 UPI000486AF52 UPI000B7E29F1 L0K928 A0A0F2PU86 A0A0M2U0A5	Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644) Halonatronum saccharophilum Desulfotomaculum gibsoniae DSM 7213 Desulfitibacter alkalitolerans Dehalobacterium formicoaceticum Halobacteroides halobius (strain ATCC 35273 / DSM 5150 / MD-1) Peptococcaceae bacterium BRH_c4b Clostridiales bacterium PH28_bin88	300	UniRef50_C8VZ34	Cluster: Homoserine kinase	8

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001720 Genomic DNA. Translation: ACV62944.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_015757648.1. NC_013216.1.

3D structure databases

ProteinModelPortalⁱ	C8VZ34.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	485916.Dtox_2115.

STRINGⁱ

485916.Dtox_2115.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ACV62944; ACV62944; Dtox_2115.
KEGGⁱ	dae:Dtox_2115.

Phylogenomic databases

eggNOGⁱ	ENOG4105D5I. Bacteria. COG0083. LUCA.
HOGENOMⁱ	HOG000247199.
KEGG Orthology (KO) More...KOⁱ	K00872.
OMAⁱ	PDNVAPC.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H020X.

Enzyme and pathway databases

UniPathwayⁱ	UPA00050; UER00064.

UniPathwayⁱ

UPA00050; UER00064.

Family and domain databases

Gene3Dⁱ	3.30.230.10. 1 hit. 3.30.70.890. 1 hit.
HAMAPⁱ	MF_00384. Homoser_kinase. 1 hit.
InterProⁱ	View protein in InterPro IPR013750. GHMP_kinase_C_dom. IPR006204. GHMP_kinase_N_dom. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PANTHERⁱ	PTHR20861:SF8. PTHR20861:SF8. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit.
PIRSFⁱ	PIRSF000676. Homoser_kin. 1 hit.
SUPFAMⁱ	SSF54211. SSF54211. 1 hit. SSF55060. SSF55060. 1 hit.
TIGRFAMsⁱ	TIGR00191. thrB. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00627. GHMP_KINASES_ATP. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	C8VZ34_DESAS
Accessionⁱ	C8VZ34Primary (citable) accession number: C8VZ34
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 3, 2009
	Last sequence update:	November 3, 2009
	Last modified:	September 27, 2017
	This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - C8VZ34 (C8VZ34_DESAS)

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Homoserine kinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-threonine biosynthesis

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

Pathwayⁱ: L-threonine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ