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UniProtKB - C8VZ34 (C8VZ34_DESAS)

UniProt

C8VZ34 - C8VZ34_DESAS

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Protein

Homoserine kinase

Gene

thrB

Organism
Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotationSAAS annotation

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotationSAAS annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (Dtox_3165), Aspartokinase (Dtox_2117)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (Dtox_2114)
  4. Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 9611ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciDACE485916:GHUF-2178-MONOMER.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotationSAAS annotation (EC:2.7.1.39UniRule annotationSAAS annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:Dtox_2115Imported
OrganismiDesulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)Imported
Taxonomic identifieri485916 [NCBI]
Taxonomic lineageiBacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfotomaculum ›
Proteomesi
  • UP000002217 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi485916.Dtox_2115.

Structurei

3D structure databases

ProteinModelPortaliC8VZ34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 13962GHMP_kinases_NInterPro annotationAdd
BLAST
Domaini204 – 26461GHMP_kinases_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105D5I. Bacteria.
COG0083. LUCA.
HOGENOMiHOG000247199.
KOiK00872.
OMAiFVHICKV.
OrthoDBiPOG091H020X.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8VZ34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRVKVPATV ANLGPGFDCL GMALEFYNAV EMYEIPSGLY IEVQGEGTEL 
        60         70         80         90        100
IPKNEQNIVY QAARRVFQKV GYTPAGLKIK LTNNVPVGKG LGSSASAIVG 
       110        120        130        140        150
GIIAANVMSG KQLKEKDLLS LAAEIEGHPD NVAPALLGGI IVSVSLEGDI 
       160        170        180        190        200
KYIKITPPSQ LKCVVAVPDF CLSTKTSREA LPQQVSFNDA VFNIGRVALL 
       210        220        230        240        250
VASLQQGELG LLSVAMDDRM HQSYRSGLIP GMKKVMAAAK LAGARGVTLS 
       260        270        280        290        300
GAGPTLIAFA DNNMELISKV MKDTFRQNGI MAKVYILNPS PVGSMTLCCT
Length:300
Mass (Da):31,755
Last modified:November 3, 2009 - v1
Checksum:iA08FE66B92A0D710
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001720 Genomic DNA. Translation: ACV62944.1.
RefSeqiWP_015757648.1. NC_013216.1.

Genome annotation databases

EnsemblBacteriaiACV62944; ACV62944; Dtox_2115.
KEGGidae:Dtox_2115.
PATRICi21721099. VBIDesAce42372_2160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001720 Genomic DNA. Translation: ACV62944.1.
RefSeqiWP_015757648.1. NC_013216.1.

3D structure databases

ProteinModelPortaliC8VZ34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi485916.Dtox_2115.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV62944; ACV62944; Dtox_2115.
KEGGidae:Dtox_2115.
PATRICi21721099. VBIDesAce42372_2160.

Phylogenomic databases

eggNOGiENOG4105D5I. Bacteria.
COG0083. LUCA.
HOGENOMiHOG000247199.
KOiK00872.
OMAiFVHICKV.
OrthoDBiPOG091H020X.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.
BioCyciDACE485916:GHUF-2178-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC8VZ34_DESAS
AccessioniPrimary (citable) accession number: C8VZ34
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.