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C8VX81

- C8VX81_DESAS

UniProt

C8VX81 - C8VX81_DESAS

Protein

Alanine racemase

Gene

Dtox_3770

Organism
Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei135 – 1351SubstrateUniRule annotation
    Active sitei266 – 2661Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei314 – 3141Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciDACE485916:GHUF-3861-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:Dtox_3770Imported
    OrganismiDesulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)Imported
    Taxonomic identifieri485916 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
    ProteomesiUP000002217: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi485916.Dtox_3770.

    Structurei

    3D structure databases

    ProteinModelPortaliC8VX81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiLWQLEAI.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C8VX81-1 [UniParc]FASTAAdd to Basket

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    MYEKTTWAEI NLSAIAHNIQ ELRRIAAPGA QLMAVVKADA YGHGAVETAR    50
    IALDNGVVIL AVSRVSEGVA LREAGIDCPV LVLGYLSPGE VLFSLKNDLS 100
    HTVFNMQQAE ILSDIATKAG IKAKVHIKIE TGMGRLGFEA CQAVVEQVIA 150
    VTRLSHLKVD GIFTHFAVSD IIDKSYTRQQ LFRFQEVLRE LHRKGVDIQL 200
    KHAANSAAII DMPDTHLNMV RAGIAMYGLY PSEGVDKSRI VLQPAMSFKT 250
    QVGHIKRVPA GYPVSYGCTY ITRRPTLIAT LPVGYADGYS RLLSSRAEVL 300
    IHGQRAPVVG RVCMDQCMID VGHINDPLIG DEVVLWGQQG ESSLPVEEVA 350
    EKMGTINYEL VCMVNVRVPR VYI 373
    Length:373
    Mass (Da):40,857
    Last modified:November 3, 2009 - v1
    Checksum:iD10D5AE5C4E88DA5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001720 Genomic DNA. Translation: ACV64477.1.
    RefSeqiWP_015759161.1. NC_013216.1.
    YP_003193100.1. NC_013216.1.

    Genome annotation databases

    EnsemblBacteriaiACV64477; ACV64477; Dtox_3770.
    GeneIDi8430780.
    KEGGidae:Dtox_3770.
    PATRICi21724513. VBIDesAce42372_3841.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001720 Genomic DNA. Translation: ACV64477.1 .
    RefSeqi WP_015759161.1. NC_013216.1.
    YP_003193100.1. NC_013216.1.

    3D structure databases

    ProteinModelPortali C8VX81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 485916.Dtox_3770.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACV64477 ; ACV64477 ; Dtox_3770 .
    GeneIDi 8430780.
    KEGGi dae:Dtox_3770.
    PATRICi 21724513. VBIDesAce42372_3841.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi LWQLEAI.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci DACE485916:GHUF-3861-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49208 / DSM 771 / VKM B-1644Imported.

    Entry informationi

    Entry nameiC8VX81_DESAS
    AccessioniPrimary (citable) accession number: C8VX81
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3