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C8VX81

- C8VX81_DESAS

UniProt

C8VX81 - C8VX81_DESAS

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Protein

Alanine racemase

Gene

Dtox_3770

Organism
Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei266 – 2661Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei314 – 3141Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDACE485916:GHUF-3861-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Dtox_3770Imported
OrganismiDesulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644)Imported
Taxonomic identifieri485916 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
ProteomesiUP000002217: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi485916.Dtox_3770.

Structurei

3D structure databases

ProteinModelPortaliC8VX81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiLWQLEAI.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8VX81-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYEKTTWAEI NLSAIAHNIQ ELRRIAAPGA QLMAVVKADA YGHGAVETAR
60 70 80 90 100
IALDNGVVIL AVSRVSEGVA LREAGIDCPV LVLGYLSPGE VLFSLKNDLS
110 120 130 140 150
HTVFNMQQAE ILSDIATKAG IKAKVHIKIE TGMGRLGFEA CQAVVEQVIA
160 170 180 190 200
VTRLSHLKVD GIFTHFAVSD IIDKSYTRQQ LFRFQEVLRE LHRKGVDIQL
210 220 230 240 250
KHAANSAAII DMPDTHLNMV RAGIAMYGLY PSEGVDKSRI VLQPAMSFKT
260 270 280 290 300
QVGHIKRVPA GYPVSYGCTY ITRRPTLIAT LPVGYADGYS RLLSSRAEVL
310 320 330 340 350
IHGQRAPVVG RVCMDQCMID VGHINDPLIG DEVVLWGQQG ESSLPVEEVA
360 370
EKMGTINYEL VCMVNVRVPR VYI
Length:373
Mass (Da):40,857
Last modified:November 3, 2009 - v1
Checksum:iD10D5AE5C4E88DA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001720 Genomic DNA. Translation: ACV64477.1.
RefSeqiYP_003193100.1. NC_013216.1.

Genome annotation databases

EnsemblBacteriaiACV64477; ACV64477; Dtox_3770.
GeneIDi8430780.
KEGGidae:Dtox_3770.
PATRICi21724513. VBIDesAce42372_3841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001720 Genomic DNA. Translation: ACV64477.1 .
RefSeqi YP_003193100.1. NC_013216.1.

3D structure databases

ProteinModelPortali C8VX81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 485916.Dtox_3770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACV64477 ; ACV64477 ; Dtox_3770 .
GeneIDi 8430780.
KEGGi dae:Dtox_3770.
PATRICi 21724513. VBIDesAce42372_3841.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi LWQLEAI.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci DACE485916:GHUF-3861-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49208 / DSM 771 / VKM B-1644Imported.

Entry informationi

Entry nameiC8VX81_DESAS
AccessioniPrimary (citable) accession number: C8VX81
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3