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C8VP36

- 6PGD_EMENI

UniProt

C8VP36 - 6PGD_EMENI

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

AN10233

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

    Catalytic activityi

    6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei96 – 961NADPBy similarity
    Binding sitei96 – 961SubstrateBy similarity
    Active sitei178 – 1781Proton acceptorBy similarity
    Active sitei185 – 1851Proton donorBy similarity
    Binding sitei300 – 3001SubstrateBy similarity
    Binding sitei468 – 4681Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 186NADPBy similarity
    Nucleotide bindingi24 – 263NADPBy similarity
    Nucleotide bindingi68 – 703NADPBy similarity

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-gluconate metabolic process Source: UniProtKB-KW
    2. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Gluconate utilization, Pentose shunt

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00410.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
    Gene namesi
    ORF Names:AN10233
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome VII

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4964966-phosphogluconate dehydrogenase, decarboxylatingPRO_0000415144Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliC8VP36.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni122 – 1243Substrate bindingBy similarity
    Regioni181 – 1822Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    OMAiLDGGNEW.
    OrthoDBiEOG7F252Z.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006115. 6PGDH_NADP-bd.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C8VP36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSMMAFAFS EIGLDVSIWD VKYDNVQQLL ESAKNTNYKG KIEGFKDVSK    50
    FTQSLEGKAE RKIFLFSITH GDPADSVLDM IKKDLKKGDI ILDGGNENYR 100
    RTEARQKICE KIGVSWIGLG VSGGYQSARR GPSLSPGGDK EALDLVMPLL 150
    ELYAGKDAKS GQPCVTRIGP KGSGHFVKMV HNGIEGGMLS TLAEAWSLLH 200
    YGRGMGYEEI ADLFESWNKE GVLRNNYLLE IGAELLRVKK TPQGDGNGEG 250
    VGDGGFVLDD VLDKVVQDDD NTEGTPYWSV MESASRHISA PTLATAHFMR 300
    IASGNRIERL EVAKQLRIPS PSPIRGMKDI EAFKEHLHSA VYSSFLASFC 350
    QGLELIARAS EDEGWDIDLG KCLQIWRSGC IIRSEGIADI LQPAVSGNKG 400
    IKNMKYIDTV AQELHRTYPS LKEIVMAATD SDHYIPAISA TLEYLKYEGG 450
    TNLPTKFMEA QMDFFGAHGY NLPGVPGEDP GPVSKGPHHY EWRPAK 496
    Length:496
    Mass (Da):54,500
    Last modified:November 3, 2009 - v1
    Checksum:iE7D424769A85EAC4
    GO

    Sequence cautioni

    The sequence EAA64021.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene AN1735 has been split into 2 genes: AN10230 and AN10233.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000027 Genomic DNA. Translation: EAA64021.1. Sequence problems.
    BN001307 Genomic DNA. Translation: CBF85462.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00008380; CADANIAP00008380; CADANIAG00008380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACD01000027 Genomic DNA. Translation: EAA64021.1 . Sequence problems.
    BN001307 Genomic DNA. Translation: CBF85462.1 .

    3D structure databases

    ProteinModelPortali C8VP36.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00008380 ; CADANIAP00008380 ; CADANIAG00008380 .

    Phylogenomic databases

    OMAi LDGGNEW.
    OrthoDBi EOG7F252Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00410 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    1.20.5.320. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR006114. 6PGDH_C.
    IPR006115. 6PGDH_NADP-bd.
    IPR013328. DH_multihelical.
    IPR012284. Fibritin/6PGD_C-extension.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00393. 6PGD. 1 hit.
    PF03446. NAD_binding_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry namei6PGD_EMENI
    AccessioniPrimary (citable) accession number: C8VP36
    Secondary accession number(s): Q5BCJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3