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C8VBH4

- ESA1_EMENI

UniProt

C8VBH4 - ESA1_EMENI

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Protein

Histone acetyltransferase esa1

Gene

esa1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei362 – 3621Important for catalytic activityBy similarity
Active sitei396 – 3961Proton donor/acceptorBy similarity
Binding sitei400 – 4001Acetyl-CoABy similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. histone acetylation Source: ASPGD
  2. regulation of secondary metabolite biosynthetic process Source: ASPGD
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase esa1 (EC:2.3.1.48By similarity)
Gene namesi
Name:esa1
ORF Names:AN10956
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome IV

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Histone acetyltransferase esa1PRO_0000413170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei320 – 3201N6-acetyllysine; by autocatalysisBy similarity

Post-translational modificationi

Autoacetylation at Lys-320 is required for proper function.By similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00000591.

Structurei

3D structure databases

ProteinModelPortaliC8VBH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 496277MYST-type HATAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni361 – 3655Acetyl-CoA bindingBy similarity
Regioni370 – 3767Acetyl-CoA bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi303 – 32422ESA1-RPD3 motifBy similarityAdd
BLAST

Domaini

The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.By similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Phylogenomic databases

HOGENOMiHOG000182457.
InParanoidiC8VBH4.
KOiK12860.
OMAiDVTPFMY.
OrthoDBiEOG7RFTRR.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR021786. DUF3351.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
[Graphical view]
PfamiPF01853. MOZ_SAS. 1 hit.
PF11831. Myb_Cef. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS51726. MYST_HAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8VBH4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGVRDSHGEA AGTPDPVEKG IATLNTIRIG VKAMVHKDGA LRKAEILSIK
60 70 80 90 100
QRKDGLAFYV HYVDFNKRLD EWVASSRLDL SQEVEWPQPE KPEKKKSGPA
110 120 130 140 150
KAPSKNKRVR AGSRDVSATP DTLTGKNTNV GKAQRPSKAG GKENRGDETP
160 170 180 190 200
ADLSMLASEA VSADGTPKAV SEDIDMMDAS FTDAKEIKEE ERALGLMSRE
210 220 230 240 250
EEIEKLRTSG SMTQNPTEVH RVRNLDRLQM GKYDIEPWYF SPYPASFSDA
260 270 280 290 300
EVVYIDEFCL SYFDNKRAFE RHRTKCTLTH PPGNEIYRDD NISFFEVDGR
310 320 330 340 350
RQRTWCRNLC LLSKLFLDHK TLYYDVDPFL FYCMCTRDET GCHLVGYFSK
360 370 380 390 400
EKESGEGYNL ACILTLPQYQ RRGYGRLLIS FSYELSKREG KVGSPEKPLS
410 420 430 440 450
DLGLLGYRQY WRETLVEILL DSGRETVSEN ELAMLTSMTE KDVHETLVTF
460 470 480 490 500
KMLRYNKGQW IIVLTDEVIE ERNKRLEKEK IKGSRKIDPA RLQWKPPVFT

ASSRTWNW
Length:508
Mass (Da):58,152
Last modified:November 3, 2009 - v1
Checksum:i148B5CA949A47101
GO

Sequence cautioni

The sequence EAA62075.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene AN7495 has been split into 2 genes: AN10944 and AN10956.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000129 Genomic DNA. Translation: EAA62075.1. Sequence problems.
BN001304 Genomic DNA. Translation: CBF79494.1.
RefSeqiXP_680764.1. XM_675672.1.

Genome annotation databases

EnsemblFungiiCADANIAT00000591; CADANIAP00000591; CADANIAG00000591.
GeneIDi2869457.
KEGGiani:AN7495.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACD01000129 Genomic DNA. Translation: EAA62075.1 . Sequence problems.
BN001304 Genomic DNA. Translation: CBF79494.1 .
RefSeqi XP_680764.1. XM_675672.1.

3D structure databases

ProteinModelPortali C8VBH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 162425.CADANIAP00000591.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00000591 ; CADANIAP00000591 ; CADANIAG00000591 .
GeneIDi 2869457.
KEGGi ani:AN7495.2.

Phylogenomic databases

HOGENOMi HOG000182457.
InParanoidi C8VBH4.
KOi K12860.
OMAi DVTPFMY.
OrthoDBi EOG7RFTRR.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR021786. DUF3351.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
[Graphical view ]
Pfami PF01853. MOZ_SAS. 1 hit.
PF11831. Myb_Cef. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view ]
SMARTi SM00298. CHROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEi PS51726. MYST_HAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  2. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiESA1_EMENI
AccessioniPrimary (citable) accession number: C8VBH4
Secondary accession number(s): Q5AW35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: November 3, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3