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Protein

Histone acetyltransferase esa1

Gene

esa1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei362Important for catalytic activityBy similarity1
Active sitei396Proton donor/acceptorBy similarity1
Binding sitei400Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri253 – 278C2HC MYST-type; degeneratePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase esa1 (EC:2.3.1.48By similarity)
Gene namesi
Name:esa1
ORF Names:AN10956
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome IV
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004131701 – 508Histone acetyltransferase esa1Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei320N6-acetyllysine; by autocatalysisBy similarity1

Post-translational modificationi

Autoacetylation at Lys-320 is required for proper function.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiC8VBH4

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00000591

Structurei

3D structure databases

ProteinModelPortaliC8VBH4
SMRiC8VBH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 496MYST-type HATPROSITE-ProRule annotationAdd BLAST277

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni361 – 365Acetyl-CoA bindingBy similarity5
Regioni370 – 376Acetyl-CoA bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi303 – 324ESA1-RPD3 motifBy similarityAdd BLAST22

Domaini

The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.By similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri253 – 278C2HC MYST-type; degeneratePROSITE-ProRule annotationAdd BLAST26

Phylogenomic databases

HOGENOMiHOG000182457
InParanoidiC8VBH4
KOiK12860
OMAiIRPWYFS
OrthoDBiEOG092C043Q

Family and domain databases

CDDicd00024 CHROMO, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR037995 Esa1/KAT5/Tip60
IPR002717 HAT_MYST-type
IPR025995 Tudor-knot
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR10615:SF124 PTHR10615:SF124, 1 hit
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF11717 Tudor-knot, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51726 MYST_HAT, 1 hit

Sequencei

Sequence statusi: Complete.

C8VBH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVRDSHGEA AGTPDPVEKG IATLNTIRIG VKAMVHKDGA LRKAEILSIK
60 70 80 90 100
QRKDGLAFYV HYVDFNKRLD EWVASSRLDL SQEVEWPQPE KPEKKKSGPA
110 120 130 140 150
KAPSKNKRVR AGSRDVSATP DTLTGKNTNV GKAQRPSKAG GKENRGDETP
160 170 180 190 200
ADLSMLASEA VSADGTPKAV SEDIDMMDAS FTDAKEIKEE ERALGLMSRE
210 220 230 240 250
EEIEKLRTSG SMTQNPTEVH RVRNLDRLQM GKYDIEPWYF SPYPASFSDA
260 270 280 290 300
EVVYIDEFCL SYFDNKRAFE RHRTKCTLTH PPGNEIYRDD NISFFEVDGR
310 320 330 340 350
RQRTWCRNLC LLSKLFLDHK TLYYDVDPFL FYCMCTRDET GCHLVGYFSK
360 370 380 390 400
EKESGEGYNL ACILTLPQYQ RRGYGRLLIS FSYELSKREG KVGSPEKPLS
410 420 430 440 450
DLGLLGYRQY WRETLVEILL DSGRETVSEN ELAMLTSMTE KDVHETLVTF
460 470 480 490 500
KMLRYNKGQW IIVLTDEVIE ERNKRLEKEK IKGSRKIDPA RLQWKPPVFT

ASSRTWNW
Length:508
Mass (Da):58,152
Last modified:November 3, 2009 - v1
Checksum:i148B5CA949A47101
GO

Sequence cautioni

The sequence EAA62075 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene AN7495 has been split into 2 genes: AN10944 and AN10956.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000129 Genomic DNA Translation: EAA62075.1 Sequence problems.
BN001304 Genomic DNA Translation: CBF79494.1
RefSeqiXP_680764.1, XM_675672.1

Genome annotation databases

EnsemblFungiiCADANIAT00000591; CADANIAP00000591; CADANIAG00000591
EAA62075; EAA62075; AN7495.2
GeneIDi2869457
KEGGiani:AN7495.2

Similar proteinsi

Entry informationi

Entry nameiESA1_EMENI
AccessioniPrimary (citable) accession number: C8VBH4
Secondary accession number(s): Q5AW35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: November 3, 2009
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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