C8UNU5 (C8UNU5_ECO1A) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
D-amino acid dehydrogenase small subunit HAMAP MF_01202
EC=1.4.99.1 HAMAP MF_01202

Gene names

Name:	dadA HAMAP MF_01202 EMBL BAI35445.1
Ordered Locus Names:	ECO111_1518

Organism

Escherichia coli O111:H- (strain 11128 / EHEC) [Complete proteome] [HAMAP]

Taxonomic identifier

585396 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Oxidative deamination of D-amino acids By similarity. HAMAP MF_01202 SAAS SAAS023080
Catalytic activity	A D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor. HAMAP MF_01202 SAAS SAAS023080
Cofactor	FAD By similarity. HAMAP MF_01202 SAAS SAAS023080
Pathway	Amino-acid degradation; D-alanine degradation; NH(3) and pyruvate from D-alanine: step 1/1. HAMAP MF_01202
Subunit structure	Heterodimer of a small and a large subunit By similarity. HAMAP MF_01202 SAAS SAAS023080
Sequence similarities	Belongs to the DadA oxidoreductase family. HAMAP MF_01202

Ontologies

Keywords
Ligand	FAD HAMAP MF_01202 SAAS SAAS023080 Flavoprotein HAMAP MF_01202 SAAS SAAS023080
Molecular function	Oxidoreductase HAMAP MF_01202 SAAS SAAS023080
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	D-amino-acid dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	3 – 17	15	FAD By similarity HAMAP MF_01202

Sequences

	Sequence		Length	Mass (Da)
	C8UNU5 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: EE747358845B6280	FASTA	432	47,607
	10 20 30 40 50 60 MRVVILGSGV VGVASAWYLN QAGHEVTVID REPGAALETS AANAGQISPG YAAPWAAPGV 70 80 90 100 110 120 PLKAIKWMFQ RHAPLAVRLD GTQFQLKWMW QMLRNCDTSH YMENKGRMVR LAEYSRDCLK 130 140 150 160 170 180 ALRAETNIQY EGRQGGTLQL FRTEQQYENA TRDIAVLEDA GVPYQLLESS RLAEVEPALA 190 200 210 220 230 240 EVAHKLTGGL QLPNDETGDC QLFTQNLARM AEQAGVKFRF NTPVDQLLCD GEQIYGVKCG 250 260 270 280 290 300 DEVIKADAYV MAFGSYSTAM LKGIVDIPVY PLKGYSLTIP IAQEDGAPVS TILDETYKIA 310 320 330 340 350 360 ITRFDNRIRV GGMAEIVGFN TELLQPRRET LEMVVRDLYP RGGHVEQATF WTGLRPMTPD 370 380 390 400 410 420 GTPVVGRTRF KNLWLNTGHG TLGWTMACGS GQLLSDLLSG RTPAIPYEDL SVARYSRGFT 430 PSRPGHLHGA HS

References

[1]

"Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli." Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K., Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M., Hayashi T. Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009) [PubMed: 19815525] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 11128 / EHEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP010960 Genomic DNA. Translation: BAI35445.1.
RefSeq	YP_003233996.1. NC_013364.1.
3D structure databases
ProteinModelPortal	C8UNU5.
SMR	C8UNU5. Positions 2-34, 200-257.
ModBase	Search...
Protein-protein interaction databases
STRING	C8UNU5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000182318; EBESCP00000173294; EBESCG00000182774.
GeneID	8488708.
GenomeReviews	Gene locus ECO111_1518 in contig AP010960_GR.
KEGG	eoi:ECO111_1518.
PATRIC	32106225. VBIEscCol143187_1576.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000011432.
ProtClustDB	PRK00711.
Family and domain databases
HAMAP	MF_01202. DadA. [Tree]
InterPro	IPR023080. D-aa_DH_ssu_DadA. IPR006076. FAD-dep_OxRdtase. [Graphical view]
KO	K00285.
Pfam	PF01266. DAO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C8UNU5_ECO1A

Accession

Primary (citable) accession number: C8UNU5

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	December 14, 2011
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)