C8UIY8 (C8UIY8_ECO1A) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
EC=1.1.1.17 HAMAP MF_00196

Gene names

Name:	mtlD HAMAP MF_00196 EMBL BAI38182.1
Ordered Locus Names:	ECO111_4421

Organism

Escherichia coli O111:H- (strain 11128 / EHEC) [Complete proteome] [HAMAP]

Taxonomic identifier

585396 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196 SAAS SAAS000669
Sequence similarities	Belongs to the mannitol dehydrogenase family. HAMAP MF_00196

Ontologies

Keywords
Ligand	NAD HAMAP MF_00196 SAAS SAAS000669
Molecular function	Oxidoreductase HAMAP MF_00196 SAAS SAAS023028
PTM	Acetylation HAMAP MF_00196
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity HAMAP MF_00196
Amino acid modifications
	Modified residue	269	1	N6-acetyllysine By similarity HAMAP MF_00196

Sequences

	Sequence		Length	Mass (Da)
	C8UIY8 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: 0EE8392D33C58CDE	FASTA	382	41,139
	10 20 30 40 50 60 MKALHFGAGN IGRGFIGKLL ADAGIQLTFA DVNQVVLDAL NARHSYQVHV VGETEQVDTV 70 80 90 100 110 120 SGVNAVSSIG DDVVDLIAQV DLVTTAVGPV VLERIAPAIA KGLVKRKEQG NESPLNIIAC 130 140 150 160 170 180 ENMVRGTTQL KGHVMNALPE DAKAWVEEHV GFVDSAVDRI VPPSASATND PLEVTVETFS 190 200 210 220 230 240 EWIVDKTQFK GALPNIPGME LTDNLMAFVE RKLFTLNTGH AITAYLGKLA GHQTIRDAIL 250 260 270 280 290 300 DEKIRAVVKG AMEESGAVLI KRYGFDADKH AAYIQKILGR FENPYLKDDV ERVGRQPLRK 310 320 330 340 350 360 LSAGDRLIKP LLGTLEYSLP HKNLIQGIAG AMHFRSEDDP QAQELAALIA DKGPQAALAQ 370 380 ISGLDANSEV VSEAVTAYKA MQ

References

[1]

"Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli." Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K., Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M., Hayashi T. Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009) [PubMed: 19815525] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 11128 / EHEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP010960 Genomic DNA. Translation: BAI38182.1.
RefSeq	YP_003236733.1. NC_013364.1.
3D structure databases
ProteinModelPortal	C8UIY8.
SMR	C8UIY8. Positions 1-382.
ModBase	Search...
Protein-protein interaction databases
STRING	C8UIY8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000185071; EBESCP00000170328; EBESCG00000180904.
GeneID	8487348.
GenomeReviews	Gene locus ECO111_4421 in contig AP010960_GR.
KEGG	eoi:ECO111_4421.
PATRIC	32112350. VBIEscCol143187_4577.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000009063.
ProtClustDB	PRK02318.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR023027. Mannitol_DH_CS. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00009.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C8UIY8_ECO1A

Accession

Primary (citable) accession number: C8UIY8

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)