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Protein

Sulfate adenylyltransferase subunit 2

Gene

cysD

Organism
Escherichia coli O103:H2 (strain 12009 / EHEC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + sulfate = diphosphate + adenylyl sulfate.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. sulfate adenylyltransferase (ATP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. hydrogen sulfide biosynthetic process Source: UniProtKB-UniPathway
  2. sulfate assimilation Source: UniProtKB-HAMAP
  3. sulfate reduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL585395:GJA9-3408-MONOMER.
UniPathwayiUPA00140; UER00204.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate adenylyltransferase subunit 2UniRule annotation (EC:2.7.7.4UniRule annotation)
Alternative name(s):
ATP-sulfurylase small subunitUniRule annotation
Sulfate adenylate transferaseUniRule annotation
Gene namesi
Name:cysDUniRule annotationImported
Ordered Locus Names:ECO103_3294Imported
OrganismiEscherichia coli O103:H2 (strain 12009 / EHEC)Imported
Taxonomic identifieri585395 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000959: Chromosome

Interactioni

Subunit structurei

Heterodimer composed of CysD, the smaller subunit, and CysN.UniRule annotation

Protein-protein interaction databases

STRINGi585395.ECO103_3294.

Structurei

3D structure databases

ProteinModelPortaliC8U9I4.
SMRiC8U9I4. Positions 5-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAPS reductase family. CysD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0175.
HOGENOMiHOG000263604.
KOiK00957.
OMAiQSASMEK.
OrthoDBiEOG6W45TZ.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00064. Sulf_adenylyltr_sub2.
InterProiIPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
IPR011784. SO4_adenylTrfase_ssu.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF002936. CysDAde_trans. 1 hit.
TIGRFAMsiTIGR02039. CysD. 1 hit.

Sequencei

Sequence statusi: Complete.

C8U9I4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQKRLTHLR QLEAESIHII REVAAEFSNP VMLYSIGKDS SVMLHLARKA
60 70 80 90 100
FYPGTLPFPL LHVDTGWKFR EMYEFRDRTA KAYGCELLVH KNPEGVAMGI
110 120 130 140 150
NPFVHGSAKH TDIMKTEGLK QALNKYGFDA AFGGARRDEE KSRAKERIYS
160 170 180 190 200
FRDRFHRWDP KNQRPELWHN YNGQINKGES IRVFPLSNWT EQDIWQYIWL
210 220 230 240 250
ENIDIVPLYL AAERPVLERD GMLMMIDDNR IDLQPGEVIK KRMVRFRTLG
260 270 280 290 300
CWPLTGAVES NAQTLPEIIE EMLVSTTSER QGRVIDRDQA GSMELKKRQG

YF
Length:302
Mass (Da):35,203
Last modified:November 3, 2009 - v1
Checksum:i825263606FC8858E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010958 Genomic DNA. Translation: BAI32043.1.
RefSeqiYP_003223177.1. NC_013353.1.

Genome annotation databases

EnsemblBacteriaiBAI32043; BAI32043; ECO103_3294.
GeneIDi8475009.
KEGGieoh:ECO103_3294.
PATRICi32098567. VBIEscCol146794_3445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010958 Genomic DNA. Translation: BAI32043.1.
RefSeqiYP_003223177.1. NC_013353.1.

3D structure databases

ProteinModelPortaliC8U9I4.
SMRiC8U9I4. Positions 5-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi585395.ECO103_3294.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI32043; BAI32043; ECO103_3294.
GeneIDi8475009.
KEGGieoh:ECO103_3294.
PATRICi32098567. VBIEscCol146794_3445.

Phylogenomic databases

eggNOGiCOG0175.
HOGENOMiHOG000263604.
KOiK00957.
OMAiQSASMEK.
OrthoDBiEOG6W45TZ.

Enzyme and pathway databases

UniPathwayiUPA00140; UER00204.
BioCyciECOL585395:GJA9-3408-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00064. Sulf_adenylyltr_sub2.
InterProiIPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
IPR011784. SO4_adenylTrfase_ssu.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFiPIRSF002936. CysDAde_trans. 1 hit.
TIGRFAMsiTIGR02039. CysD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli."
    Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K., Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M., Hayashi T.
    Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12009 / EHECImported.

Entry informationi

Entry nameiC8U9I4_ECO10
AccessioniPrimary (citable) accession number: C8U9I4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: February 4, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.