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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdF

Organism
Escherichia coli O103:H2 (strain 12009 / EHEC)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 2 iron ions per subunit.UniRule annotation

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Iron 1UniRule annotation1
Metal bindingi98Iron 1UniRule annotation1
Metal bindingi98Iron 2UniRule annotation1
Metal bindingi101Iron 1UniRule annotation1
Active sitei105UniRule annotation1
Metal bindingi158Iron 2UniRule annotation1
Metal bindingi192Iron 2UniRule annotation1
Metal bindingi195Iron 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processDNA replicationUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit betaUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Name:nrdFImported
Ordered Locus Names:ECO103_3217Imported
OrganismiEscherichia coli O103:H2 (strain 12009 / EHEC)Imported
Taxonomic identifieri585395 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000959 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliC8U9A9.
SMRiC8U9A9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase small chain family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246153.
KOiK00526.
OMAiIGYKYQR.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
InterProiView protein in InterPro
IPR009078. Ferritin-like_SF.
IPR026494. RNR_NrdF.
IPR033909. RNR_small.
IPR030475. RNR_small_AS.
IPR000358. RNR_small_fam.
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiView protein in Pfam
PF00268. Ribonuc_red_sm. 1 hit.
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR04171. RNR_1b_NrdF. 1 hit.
PROSITEiView protein in PROSITE
PS00368. RIBORED_SMALL. 1 hit.

Sequencei

Sequence statusi: Complete.

C8U9A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSRISAIN WNKISDDKDL EVWNRLTSNF WLPEKVPLSN DIPAWQTLTV
60 70 80 90 100
VEQQLTMRVF TGLTLLDTLQ NVIGAPSLMP DALTPHEEAV LSNISFMEAV
110 120 130 140 150
HARSYSSIFS TLCQTKDVDA AYAWSEENAP LQRKAQIIQQ HYRGDDPLKK
160 170 180 190 200
KIASVFLESF LFYSGFWLPM YFSSRGKLTN TADLIRLIIR DEAVHGYYIG
210 220 230 240 250
YKYQKNMEKI SLGQREELKS FAFDLLLELY DNELQYTDEL YAETPWADDV
260 270 280 290 300
KAFLCYNANK ALMNLGYEPL FPAEMAEVNP AILAALSPNA DENHDFFSGS
310
GSSYVMGKAV ETEDEDWNF
Length:319
Mass (Da):36,443
Last modified:November 3, 2009 - v1
Checksum:i0C95394CF150EEFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010958 Genomic DNA. Translation: BAI31968.1.
RefSeqiWP_000777969.1. NC_013353.1.

Genome annotation databases

EnsemblBacteriaiBAI31968; BAI31968; ECO103_3217.
KEGGieoh:ECO103_3217.

Similar proteinsi

Entry informationi

Entry nameiC8U9A9_ECO10
AccessioniPrimary (citable) accession number: C8U9A9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: June 7, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported