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C8U849 (C8U849_ECO10) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of ThiI in a transpersulfidation reaction. Functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate By similarity. HAMAP-Rule MF_00331

Catalytic activity

L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor. HAMAP-Rule MF_00331 SAAS SAAS020578

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00331 RuleBase RU004504 SAAS SAAS020578

Sequence similarities

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. HAMAP-Rule MF_00331

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site3281Cysteine persulfide intermediate By similarity HAMAP-Rule MF_00331

Amino acid modifications

Modified residue2061N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_00331

Sequences

Sequence LengthMass (Da)Tools
C8U849 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: 67A7FB33FD340F85

FASTA40445,105
        10         20         30         40         50         60 
MKLPIYLDYS ATTPVDPRVA EKMMQFMTMD GTFGNPASRS HRFGWQAEEA VDIARNQIAD 

        70         80         90        100        110        120 
LVGADPREIV FTSGATESDN LSIKGAANFY QKKGKHIITS KTEHKAVLDT CRQLEREGFE 

       130        140        150        160        170        180 
VTYLAPQRNG IIDLKELEAA MRDDTILVSI MHVNNEIGVV QDIAAIGEMC RARGIIYHVD 

       190        200        210        220        230        240 
ATQSVGKLPI DLSQLKVDLM SFSGHKIYGP KGIGALYVRR KPRVRIEAQM HGGGHERGMR 

       250        260        270        280        290        300 
SGTLPVHQIV GMGEAYRIAK EEMATEMERL RGLRNRLWNG IKDIEEVYLN GDLEHGAPNI 

       310        320        330        340        350        360 
LNVSFNYVEG ESLIMALKDL AVSSGSACTS ASLEPSYVLR ALGLNDELAH SSIRFSLGRF 

       370        380        390        400 
TTEEEIDYTI ELVRKSIGRL RDLSPLWEMY KQGVDLNSIE WAHH

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References

[1]"Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli."
Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K., Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M., Hayashi T.
Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 12009 / EHEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP010958 Genomic DNA. Translation: BAI31804.1.
RefSeqYP_003222938.1. NC_013353.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING585395.ECO103_3047.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAI31804; BAI31804; ECO103_3047.
GeneID8475761.
KEGGeoh:ECO103_3047.
PATRIC32098042. VBIEscCol146794_3192.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1104.
HOGENOMHOG000017510.
KOK04487.
OMALWEMFKQ.
ProtClustDBPRK14012.

Enzyme and pathway databases

BioCycECOL585395:GJA9-3146-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_00331. Cys_desulf_aminotr_5.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR010240. Cys_deSase.
IPR016454. Cysteine_dSase_NifS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF005572. NifS. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR02006. IscS. 1 hit.
PROSITEPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC8U849_ECO10
AccessionPrimary (citable) accession number: C8U849
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info