Skip Header

Contribute Send feedback
Read comments (?) or add your own

C8U244 (C8U244_ECO10) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase HAMAP MF_01657
EC=1.2.1.10 HAMAP MF_01657
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] HAMAP MF_01657
Gene names
Name:mhpF HAMAP MF_01657 EMBL BAI29202.1
Ordered Locus Names:ECO103_0333
OrganismEscherichia coli O103:H2 (strain 12009 / EHEC) [Complete proteome] [HAMAP]
Taxonomic identifier585395 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657 SAAS SAAS015426

Pathway

Aromatic compound metabolism; 3-phenylpropanoate degradation. HAMAP MF_01657

Subunit structure

Interacts with MhpE By similarity. HAMAP MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family. HAMAP MF_01657

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding11 – 144NAD By similarity HAMAP MF_01657
Nucleotide binding162 – 1709NAD By similarity HAMAP MF_01657

Sites

Binding site2891NAD By similarity HAMAP MF_01657

Sequences

Sequence LengthMass (Da)Tools
C8U244 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: A6918BDA5EF4876B

FASTA31633,442
        10         20         30         40         50         60 
MSKRKVAIIG SGNIGTDLMI KILRHGQHLE MAVMVGIDPQ SDGLARARRM GVATTHEGVI 

        70         80         90        100        110        120 
GLMNMPEFAD IDIVFDATSA GAHVKNDAAL REAKPDIRLI DLTPAAIGPY CVPVVNLEAN 

       130        140        150        160        170        180 
VDQLNVNMVT CGGQATIPMV AAVSRVARVH YAEIIASIAS KSAGPGTRAN IDEFTETTSR 

       190        200        210        220        230        240 
AIEVVGGAAK GKAIIVLNPA EPPLMMRDTV YVLSDEASQD DIEASINEMA EAVQAYVPGY 

       250        260        270        280        290        300 
RLKQRVQFEV IPQDKPVNLP GVGQFSGLKT AVWLEVEGAA HYLPAYAGNL DIMTSSALAT 

       310 
AEKMAQSLAR KAGEAA

« Hide

References

[1]"Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli."
Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K., Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M., Hayashi T.
Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009) [PubMed: 19815525] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 12009 EMBL BAI29202.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP010958 Genomic DNA. Translation: BAI29202.1.
RefSeqYP_003220336.1. NC_013353.1.

3D structure databases

ProteinModelPortalC8U244.
SMRC8U244. Positions 3-308.
ModBaseSearch...

Protein-protein interaction databases

STRINGC8U244.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000179086; EBESCP00000169818; EBESCG00000178775.
GeneID8476001.
GenomeReviewsGene locus ECO103_0333 in contig AP010958_GR.
KEGGeoh:ECO103_0333.
PATRIC32092246. VBIEscCol146794_0348.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000011515.
OMAHVKNDAF.
ProtClustDBPRK08300.

Family and domain databases

HAMAPMF_01657. Ac_ald_DH_ac.
[Tree]
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK04073.
PANTHERPTHR21123. Acetylald_dh. 1 hit.
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC8U244_ECO10
AccessionPrimary (citable) accession number: C8U244
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info