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C8TZK2

- C8TZK2_ECO10

UniProt

C8TZK2 - C8TZK2_ECO10

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Protein
Xylose isomerase
Gene
xylA, ECO103_4669
Organism
Escherichia coli O103:H2 (strain 12009 / EHEC)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011 By similarityUniRule annotation
Active sitei104 – 1041 By similarityUniRule annotation
Metal bindingi232 – 2321Magnesium 1 By similarityUniRule annotation
Metal bindingi268 – 2681Magnesium 1 By similarityUniRule annotation
Metal bindingi268 – 2681Magnesium 2 By similarityUniRule annotation
Metal bindingi271 – 2711Magnesium 2 By similarityUniRule annotation
Metal bindingi296 – 2961Magnesium 1 By similarityUniRule annotation
Metal bindingi307 – 3071Magnesium 2 By similarityUniRule annotation
Metal bindingi309 – 3091Magnesium 2 By similarityUniRule annotation
Metal bindingi339 – 3391Magnesium 1 By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotations, Xylose metabolismUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciECOL585395:GJA9-4836-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotationImported
Ordered Locus Names:ECO103_4669Imported
OrganismiEscherichia coli O103:H2 (strain 12009 / EHEC)Imported
Taxonomic identifieri585395 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000959: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi585395.ECO103_4669.

Structurei

3D structure databases

ProteinModelPortaliC8TZK2.
SMRiC8TZK2. Positions 2-439.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiLFHAHIG.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8TZK2-1 [UniParc]FASTAAdd to Basket

« Hide

MQAYFDQLDR VRYEGSKSSN PLAFRHYNPD ELVLGKRMEE HLRFAACYWH    50
TFCWNGADMF GVGAFNRPWQ QPGEALALAK RKADVAFEFF HKLHVPFYCF 100
HDVDVSPEGA SLKEYINNFA QMVDVLAGKQ EESGVKLLWG TANCFTNPRY 150
GAGAATNPDP EVFSWAATQV VTAMEATHKL GGENYVLWGG REGYETLLNT 200
DLRQEREQLG RFMQMVVEHK HKIGFQGTLL IEPKPQEPTK HQYDYDAATV 250
YGFLKQFGLE KEIKLNIEAN HATLAGHSFH HEIATAIALG LFGSVDANRG 300
DAQLGWDTDQ FPNSVEENAL VMYEILKAGG FTTGGLNFDA KVRRQSTDKY 350
DLFYGHIGAM DTMALALKIA ARMIEDGELD KRIAQRYSGW NSELGQQILK 400
GQMSLADLAK YAQEHNLSPV HQSGRQEQLE NLVNHYLFDK 440
Length:440
Mass (Da):49,719
Last modified:November 3, 2009 - v1
Checksum:i6E21039B6EC0561F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010958 Genomic DNA. Translation: BAI33364.1.
RefSeqiYP_003224498.1. NC_013353.1.

Genome annotation databases

EnsemblBacteriaiBAI33364; BAI33364; ECO103_4669.
GeneIDi8477130.
KEGGieoh:ECO103_4669.
PATRICi32101524. VBIEscCol146794_4893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010958 Genomic DNA. Translation: BAI33364.1 .
RefSeqi YP_003224498.1. NC_013353.1.

3D structure databases

ProteinModelPortali C8TZK2.
SMRi C8TZK2. Positions 2-439.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 585395.ECO103_4669.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAI33364 ; BAI33364 ; ECO103_4669 .
GeneIDi 8477130.
KEGGi eoh:ECO103_4669.
PATRICi 32101524. VBIEscCol146794_4893.

Phylogenomic databases

eggNOGi COG2115.
HOGENOMi HOG000252293.
KOi K01805.
OMAi LFHAHIG.
OrthoDBi EOG62NX4R.

Enzyme and pathway databases

BioCyci ECOL585395:GJA9-4836-MONOMER.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli."
    Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K., Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M., Hayashi T.
    Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12009 / EHEC.

Entry informationi

Entry nameiC8TZK2_ECO10
AccessioniPrimary (citable) accession number: C8TZK2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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