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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Escherichia coli O103:H2 (strain 12009 / EHEC)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotationSAAS annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotationImported
Biological processProtein biosynthesisUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotationSAAS annotation (EC:2.1.2.9UniRule annotationSAAS annotation)
Gene namesi
Name:fmtUniRule annotationImported
Ordered Locus Names:ECO103_4019Imported
OrganismiEscherichia coli O103:H2 (strain 12009 / EHEC)Imported
Taxonomic identifieri585395 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000959 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliC8TXR7
SMRiC8TXR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 183Formyl_trans_NInterPro annotationAdd BLAST178
Domaini207 – 304Formyl_trans_CInterPro annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 116Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

C8TXR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESLRIIFA GTPDFAARHL DALLSSGHNV VGVFTQPDRP AGRGKKLMPS
60 70 80 90 100
PVKVLAEEKG LPVFQPVSLR PQENQQLVAD LQADVMVVVA YGLILPKAVL
110 120 130 140 150
EMPRLGCINV HGSLLPRWRG AAPIQRSLWA GDAETGVTIM QMDVGLDTGD
160 170 180 190 200
MLYKLSCPIT AEDTSGTLYD KLAELGPQGL ITTLKQLADG TAKPEVQDET
210 220 230 240 250
LVTYAEKLSK EEARIDWSLS AAQLERCIRA FNPWPMSWLE IEGQPVKVWK
260 270 280 290 300
ASVIDTATNA APGTILEANK QGIQVATGDG ILNLLSLQPA GKKAMSAQDL
310
LNSRREWFVP GNRLV
Length:315
Mass (Da):34,154
Last modified:November 3, 2009 - v1
Checksum:i318CFA5BB2A77B1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010958 Genomic DNA Translation: BAI32729.1
RefSeqiWP_000004454.1, NC_013353.1

Genome annotation databases

EnsemblBacteriaiBAI32729; BAI32729; ECO103_4019
KEGGieoh:ECO103_4019

Similar proteinsi

Entry informationi

Entry nameiC8TXR7_ECO10
AccessioniPrimary (citable) accession number: C8TXR7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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