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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Escherichia coli O26:H11 (strain 11368 / EHEC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotationSAAS annotation

Cofactori

FADUniRule annotationSAAS annotation

Pathway:itricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotationSAAS annotation

Keywords - Ligandi

FADUniRule annotationSAAS annotation, Flavoprotein

Enzyme and pathway databases

BioCyciECOL573235:GCY7-3225-MONOMER.
UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotationImported
Ordered Locus Names:ECO26_3137Imported
OrganismiEscherichia coli O26:H11 (strain 11368 / EHEC)Imported
Taxonomic identifieri573235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001617 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliC8TUE9.
SMRiC8TUE9. Positions 29-69, 214-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0579.
HOGENOMiHOG000109379.
KOiK00116.
OrthoDBiEOG6X6R8Z.

Family and domain databases

HAMAPiMF_00212. MQO.
InterProiIPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

C8TUE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVTAMLFS MAVGLNAVSM AAKAKASEEQ ETDVLLIGGG IMSATLGTYL
60 70 80 90 100
RELEPEWSMT MVERLEGVAQ ESSNGWNNAG TGHSALMELN YTPQNADGSI
110 120 130 140 150
SIEKAVAINE AFQISRQFWA HQVERGVLRT PRSFINTVPH MSFVWGEDNV
160 170 180 190 200
NFLRARYAAL QQSSLFRGMR YSEDHAQIKE WAPLVMEGRD PQQKVAATRT
210 220 230 240 250
EIGTDVNYGE ITRQLIASLQ KKSNFSLQLS SEVRALKRND DNTWTVTVAD
260 270 280 290 300
LKNGTAQNIR AKFVFIGAGG AALKLLQESG IPEAKDYAGF PVGGQFLVSE
310 320 330 340 350
NPDVVNHHLA KVYGKASVGA PPMSVPHIDT RVLDGKRVVL FGPFATFSTK
360 370 380 390 400
FLKNGSLWDL MSSTTTSNVM PMMHVGLDNF DLVKYLVSQV MLSEEDRFEA
410 420 430 440 450
LKEYYPQAKK EDWRLWQAGQ RVQIIKRDAE KGGVLRLGTE VVSDQQGTIA
460 470 480 490 500
ALLGASPGAS TAAPIMLDLL EKVFGDRVSS PQWQATLKAI VPSYGRKLNG
510 520 530 540
DVAATERELQ YTSEVLGLKY DKPQAADSTP KPQLKPQPVQ KEVADIAL
Length:548
Mass (Da):60,245
Last modified:November 3, 2009 - v1
Checksum:i3F18ABBC44E6D2FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010953 Genomic DNA. Translation: BAI26349.1.
RefSeqiWP_000758074.1. NC_013361.1.

Genome annotation databases

EnsemblBacteriaiBAI26349; BAI26349; ECO26_3137.
KEGGieoj:ECO26_3137.
PATRICi18401954. VBIEscCol24965_3212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010953 Genomic DNA. Translation: BAI26349.1.
RefSeqiWP_000758074.1. NC_013361.1.

3D structure databases

ProteinModelPortaliC8TUE9.
SMRiC8TUE9. Positions 29-69, 214-320.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI26349; BAI26349; ECO26_3137.
KEGGieoj:ECO26_3137.
PATRICi18401954. VBIEscCol24965_3212.

Phylogenomic databases

eggNOGiCOG0579.
HOGENOMiHOG000109379.
KOiK00116.
OrthoDBiEOG6X6R8Z.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.
BioCyciECOL573235:GCY7-3225-MONOMER.

Family and domain databases

HAMAPiMF_00212. MQO.
InterProiIPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli."
    Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K., Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M., Hayashi T.
    Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 11368 / EHECImported.

Entry informationi

Entry nameiC8TUE9_ECO26
AccessioniPrimary (citable) accession number: C8TUE9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: July 22, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.