C8TUE9 (C8TUE9_ECO26) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase HAMAP-Rule MF_00212
EC=1.1.5.4 HAMAP-Rule MF_00212

Alternative name(s):
MQO HAMAP-Rule MF_00212
Malate dehydrogenase [quinone] HAMAP-Rule MF_00212

Gene names

Name:	mqo HAMAP-Rule MF_00212 EMBL BAI26349.1
Ordered Locus Names:	ECO26_3137 EMBL BAI26349.1

Organism

Escherichia coli O26:H11 (strain 11368 / EHEC) [Complete proteome] [HAMAP] EMBL BAI26349.1

Taxonomic identifier

573235 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli › Escherichia coli O26:H11

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP-Rule MF_00212 SAAS SAAS006231
Cofactor	FAD By similarity. HAMAP-Rule MF_00212 SAAS SAAS006231
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP-Rule MF_00212 SAAS SAAS006231
Sequence similarities	Belongs to the MQO family. HAMAP-Rule MF_00212

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle HAMAP-Rule MF_00212 SAAS SAAS006231
Ligand	FAD HAMAP-Rule MF_00212 SAAS SAAS006231 Flavoprotein HAMAP-Rule MF_00212 SAAS SAAS006231
Molecular function	Oxidoreductase HAMAP-Rule MF_00212 SAAS SAAS006231
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular_function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C8TUE9 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: 3F18ABBC44E6D2FF	FASTA	548	60,245
	10 20 30 40 50 60 MKKVTAMLFS MAVGLNAVSM AAKAKASEEQ ETDVLLIGGG IMSATLGTYL RELEPEWSMT 70 80 90 100 110 120 MVERLEGVAQ ESSNGWNNAG TGHSALMELN YTPQNADGSI SIEKAVAINE AFQISRQFWA 130 140 150 160 170 180 HQVERGVLRT PRSFINTVPH MSFVWGEDNV NFLRARYAAL QQSSLFRGMR YSEDHAQIKE 190 200 210 220 230 240 WAPLVMEGRD PQQKVAATRT EIGTDVNYGE ITRQLIASLQ KKSNFSLQLS SEVRALKRND 250 260 270 280 290 300 DNTWTVTVAD LKNGTAQNIR AKFVFIGAGG AALKLLQESG IPEAKDYAGF PVGGQFLVSE 310 320 330 340 350 360 NPDVVNHHLA KVYGKASVGA PPMSVPHIDT RVLDGKRVVL FGPFATFSTK FLKNGSLWDL 370 380 390 400 410 420 MSSTTTSNVM PMMHVGLDNF DLVKYLVSQV MLSEEDRFEA LKEYYPQAKK EDWRLWQAGQ 430 440 450 460 470 480 RVQIIKRDAE KGGVLRLGTE VVSDQQGTIA ALLGASPGAS TAAPIMLDLL EKVFGDRVSS 490 500 510 520 530 540 PQWQATLKAI VPSYGRKLNG DVAATERELQ YTSEVLGLKY DKPQAADSTP KPQLKPQPVQ KEVADIAL

References

[1]

"Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli." Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K., Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M., Hayashi T. Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 11368 / EHEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP010953 Genomic DNA. Translation: BAI26349.1.
RefSeq	YP_003230089.1. NC_013361.1.
3D structure databases
ProteinModelPortal	C8TUE9.
SMR	C8TUE9. Positions 29-69, 214-320.
ModBase	Search...
Protein-protein interaction databases
STRING	573235.ECO26_3137.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAI26349; BAI26349; ECO26_3137.
GeneID	8480919.
KEGG	eoj:ECO26_3137.
PATRIC	18401954. VBIEscCol24965_3212.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0579.
HOGENOM	HOG000109379.
KO	K00116.
ProtClustDB	PRK05257.
Enzyme and pathway databases
UniPathway	UPA00223; UER01008.
Family and domain databases
HAMAP	MF_00212. MQO.
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C8TUE9_ECO26

Accession

Primary (citable) accession number: C8TUE9

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)