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Protein

5-hydroxyisourate hydrolase

Gene

yedX

Organism
Escherichia coli O26:H11 (strain 11368 / EHEC)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Purine metabolismUniRule annotation

Enzyme and pathway databases

BioCyciECOL573235:GCY7-2931-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxyisourate hydrolaseUniRule annotation (EC:3.5.2.17UniRule annotation)
Short name:
HIU hydrolaseUniRule annotation
Short name:
HIUHaseUniRule annotation
Gene namesi
Name:yedXImported
Ordered Locus Names:ECO26_2854Imported
OrganismiEscherichia coli O26:H11 (strain 11368 / EHEC)Imported
Taxonomic identifieri573235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001617 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC8TTP0.
SMRiC8TTP0. Positions 26-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2351.
HOGENOMiHOG000251776.
KOiK07127.
OrthoDBiEOG6F55J8.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
TIGRFAMsiTIGR02962. hdxy_isourate. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8TTP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKRYLVLSV VTAAFSLPSL VYAAQQNILS VHILNQQTGK PAADVTVTLE
60 70 80 90 100
KKADNGWLQL NTAKTDKDGR IKALWPEQTA TTGDYRVVFK TGDYFKKQNL
110 120 130
ESFFPEIPVE FHINKVNEHY HVPLLLSQYG YSTYRGS
Length:137
Mass (Da):15,537
Last modified:November 3, 2009 - v1
Checksum:i0A8D534E6A46B9F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010953 Genomic DNA. Translation: BAI26090.1.
RefSeqiWP_000920132.1. NC_013361.1.

Genome annotation databases

EnsemblBacteriaiBAI26090; BAI26090; ECO26_2854.
KEGGieoj:ECO26_2854.
PATRICi18401323. VBIEscCol24965_2903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010953 Genomic DNA. Translation: BAI26090.1.
RefSeqiWP_000920132.1. NC_013361.1.

3D structure databases

ProteinModelPortaliC8TTP0.
SMRiC8TTP0. Positions 26-137.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI26090; BAI26090; ECO26_2854.
KEGGieoj:ECO26_2854.
PATRICi18401323. VBIEscCol24965_2903.

Phylogenomic databases

eggNOGiCOG2351.
HOGENOMiHOG000251776.
KOiK07127.
OrthoDBiEOG6F55J8.

Enzyme and pathway databases

BioCyciECOL573235:GCY7-2931-MONOMER.

Family and domain databases

Gene3Di2.60.40.180. 1 hit.
InterProiIPR014306. Hydroxyisourate_hydrolase.
IPR023418. Thyroxine_BS.
IPR000895. Transthyretin/HIU_hydrolase.
IPR023416. Transthyretin/HIU_hydrolase_SF.
IPR023419. Transthyretin_CS.
[Graphical view]
PfamiPF00576. Transthyretin. 1 hit.
[Graphical view]
PRINTSiPR00189. TRNSTHYRETIN.
SMARTiSM00095. TR_THY. 1 hit.
[Graphical view]
SUPFAMiSSF49472. SSF49472. 1 hit.
TIGRFAMsiTIGR02962. hdxy_isourate. 1 hit.
PROSITEiPS00768. TRANSTHYRETIN_1. 1 hit.
PS00769. TRANSTHYRETIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli."
    Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K., Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M., Hayashi T.
    Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 11368 / EHECImported.

Entry informationi

Entry nameiC8TTP0_ECO26
AccessioniPrimary (citable) accession number: C8TTP0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: July 22, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.