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C8TQK2 (C8TQK2_ECO26) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Alanine racemase 2, PLP-binding EMBL BAI25002.1
Gene names
Name:dadX EMBL BAI25002.1
Ordered Locus Names:ECO26_1703 EMBL BAI25002.1
OrganismEscherichia coli O26:H11 (strain 11368 / EHEC) [Complete proteome] [HAMAP] EMBL BAI25002.1
Taxonomic identifier573235 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-alanine = D-alanine. RuleBase RU000608 SAAS SAAS020622

Cofactor

Pyridoxal phosphate By similarity. RuleBase RU000608 SAAS SAAS020622

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. SAAS SAAS020622

Sequence similarities

Belongs to the alanine racemase family. RuleBase RU004188

Ontologies

Keywords
   LigandPyridoxal phosphate RuleBase RU000608 SAAS SAAS020622
   Molecular functionIsomerase SAAS SAAS020622 RuleBase RU000608
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
C8TQK2 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: 817FAA44C8B3ED70

FASTA35638,871
        10         20         30         40         50         60 
MTRPIQASLD LQALKQNLSI VRQAAPHARV WSVVKANAYG HGIERIWSAL GATDGFALLN 

        70         80         90        100        110        120 
LEEAITLRER GWKGPILMLE GFFHAQDLEI YDQHRLTTCV HSNWQLKALQ NARLKAPLDI 

       130        140        150        160        170        180 
YLKVNSGMNR LGFQPDRVLT VWQQLRAMAN VGEMTLMSHF AEAEHPDGIS SAMARIEQAA 

       190        200        210        220        230        240 
EGLECRRSLS NSAATLWHPE AHFDWVRPGI ILYGASPSGQ WRDIANTGLR PVMTLSSEII 

       250        260        270        280        290        300 
GVQTLKAGER VGYGGRYTAR DEQRIGIVAA GYADGYPRHA PTGTPVLVDG VRTMTVGTVS 

       310        320        330        340        350 
MDMLAVDLTP CPQAGIGTPV ELWGKEIKID DVAAAAGTVG YELMCALALR VPVVTV

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References

[1]"Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli."
Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K., Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M., Hayashi T.
Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 11368 / EHEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP010953 Genomic DNA. Translation: BAI25002.1.
RefSeqYP_003228742.1. NC_013361.1.

3D structure databases

ProteinModelPortalC8TQK2.
ModBaseSearch...

Protein-protein interaction databases

STRING573235.ECO26_1703.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAI25002; BAI25002; ECO26_1703.
GeneID8480802.
KEGGeoj:ECO26_1703.
PATRIC18398947. VBIEscCol24965_1728.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031446.
KOK01775.
ProtClustDBPRK03646.

Enzyme and pathway databases

UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC8TQK2_ECO26
AccessionPrimary (citable) accession number: C8TQK2
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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