C8NRU0 (C8NRU0_COREF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL EEW48667.1
ORF Names:	HMPREF0290_2715 EMBL EEW48667.1

Organism

Corynebacterium efficiens YS-314 EMBL EEW48667.1

Taxonomic identifier

196164 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	863 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C8NRU0 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: D0F1A6270DD03BA5	FASTA	863	95,601
	10 20 30 40 50 60 MSDDNNETFD RIQPIDINEE MQSSYIDYAM SVIVGRALPE VRDGMKPVHR RVLYAMYDNG 70 80 90 100 110 120 YRPDRSYVKS AKPVADTMGN YHPHGDTAIY DTLVRMAQPW SMRYPLVDGQ GNFGSRGNDG 130 140 150 160 170 180 PAAMRYTECR MTPLAMEMVR DIRENTVNFS PNYDGKTTEP DVLPSRVPNL LMNGSGGIAV 190 200 210 220 230 240 GMATNIPPHN LNELADAIFW LLENPDADEA TALEKCMEFV KGPDFPTAGL IIGDKGIHDA 250 260 270 280 290 300 YTTGRGSIRM RGVTSIEEEG NRTVIVITEL PYQVNPDNLI SNIAEQVRDG KLVGISKIED 310 320 330 340 350 360 ESSDRVGMRI VVTLKRDAVP RVVLNNLFKH SQLQSNFGAN MLSIVDGVPR TLRLDQMLRY 370 380 390 400 410 420 YVAHQIEVIV RRTQYRLDQA EKRAHILRGL VKALDMLDEV IALIRRSPTV EEARDGLMSL 430 440 450 460 470 480 LDVDQIQADA ILEMQLRRLA ALEREKIVNE LNELETIIAD LKDILASPER QRAIVRDELA 490 500 510 520 530 540 EIVEKYGDER RSQIIAATGD VSEEDLIARE NVVVTITSTG YAKRTKVDAY KSQKRGGKGV 550 560 570 580 590 600 RGAELKQDDI VRHFFVSSTH DWILFFTNFG RVYRLKAYEL PEASRTARGQ HVANLLEFQP 610 620 630 640 650 660 EERIAQVIQI QTYEDAPYLV LATAQGRVKK SRLTDYESAR SAGLIAINLN DGDRLIGAAL 670 680 690 700 710 720 VDEGDDILLT SEYGQAIRFT ADDEQLRPMG RATAGVKGMR FREGDQLLAM SVVRDGEFLL 730 740 750 760 770 780 VATSGGYGKR TPISEYSTQG RGGLGVVTFK YTPKRGRLIG ALAVEEDDEI FAITSAGGVI 790 800 810 820 830 840 RTEVNQIRPS SRATMGVRLV NLQDDVELLA IDKNVEEEGE EEAEAVAKGN VDGPASKIPG 850 860 KKAAAAVDAD ADAGDTDSAD GEE

References

[1]

Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R. , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R. Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: YS-314 EMBL EEW48667.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACLI01000112 Genomic DNA. Translation: EEW48667.1.
RefSeq	NP_736625.1. NC_004369.1.
3D structure databases
ProteinModelPortal	C8NRU0.
ModBase	Search...
Protein-protein interaction databases
STRING	C8NRU0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1032143.
PATRIC	21486211. VBICorEff9312_0063.
Phylogenomic databases
OMA	TGRGRIY.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C8NRU0_COREF

Accession

Primary (citable) accession number: C8NRU0

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	January 25, 2012
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)