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C8NRH0

- C8NRH0_COREF

UniProt

C8NRH0 - C8NRH0_COREF

Protein

Aspartate 1-decarboxylase

Gene

panD

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.UniRule annotationSAAS annotation

    Catalytic activityi

    L-aspartate = beta-alanine + CO2.UniRule annotationSAAS annotation

    Cofactori

    Pyruvoyl group.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei25 – 251Schiff-base intermediate with substrate; via pyruvic acidUniRule annotation
    Binding sitei57 – 571SubstrateUniRule annotation
    Active sitei58 – 581Proton donorUniRule annotation

    GO - Molecular functioni

    1. aspartate 1-decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. alanine biosynthetic process Source: InterPro
    2. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotationSAAS annotation, Lyase

    Keywords - Biological processi

    Pantothenate biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    PyruvateUniRule annotationSAAS annotation, Schiff baseUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCEFF196164:GJW8-138-MONOMER.
    UniPathwayiUPA00028; UER00002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate 1-decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation)
    Alternative name(s):
    Aspartate alpha-decarboxylaseUniRule annotation
    Gene namesi
    Name:panDUniRule annotationImported
    ORF Names:HMPREF0290_2595Imported
    OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)Imported
    Taxonomic identifieri196164 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251Pyruvic acid (Ser)UniRule annotation

    Post-translational modificationi

    Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.UniRule annotation

    Keywords - PTMi

    Autocatalytic cleavageUniRule annotation, ZymogenUniRule annotation

    Interactioni

    Subunit structurei

    Heterooctamer of four alpha and four beta subunits.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliC8NRH0.
    SMRiC8NRH0. Positions 1-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni73 – 753Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PanD family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0853.
    KOiK01579.
    OMAiELMIHIM.

    Family and domain databases

    HAMAPiMF_00446. PanD.
    InterProiIPR009010. Asp_de-COase-like_dom.
    IPR003190. Asp_decarbox.
    [Graphical view]
    PANTHERiPTHR21012. PTHR21012. 1 hit.
    PfamiPF02261. Asp_decarbox. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006246. Asp_decarbox. 1 hit.
    ProDomiPD009294. Asp_decarbox. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    TIGRFAMsiTIGR00223. panD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C8NRH0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRTILGSKI HRATVTQADL DYVGSITIDA DLVNAAGLIE GEKVAVVDIT    50
    NGARIETYVI TGDAGTGSIC INGAAAHLIN PGDLVIIMSY LQATDAEARA 100
    YQPNIVHVDA DNRIVALGND AGEPIPGSSL LSSRSL 136
    Length:136
    Mass (Da):14,098
    Last modified:November 3, 2009 - v1
    Checksum:i9C5042CB497CCC3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACLI01000106 Genomic DNA. Translation: EEW48818.1.
    RefSeqiNP_736745.1. NC_004369.1.

    Genome annotation databases

    EnsemblBacteriaiEEW48818; EEW48818; HMPREF0290_2595.
    GeneIDi1031997.
    KEGGicef:CE0135.
    PATRICi21486458. VBICorEff9312_0183.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACLI01000106 Genomic DNA. Translation: EEW48818.1 .
    RefSeqi NP_736745.1. NC_004369.1.

    3D structure databases

    ProteinModelPortali C8NRH0.
    SMRi C8NRH0. Positions 1-113.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EEW48818 ; EEW48818 ; HMPREF0290_2595 .
    GeneIDi 1031997.
    KEGGi cef:CE0135.
    PATRICi 21486458. VBICorEff9312_0183.

    Phylogenomic databases

    eggNOGi COG0853.
    KOi K01579.
    OMAi ELMIHIM.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00002 .
    BioCyci CEFF196164:GJW8-138-MONOMER.

    Family and domain databases

    HAMAPi MF_00446. PanD.
    InterProi IPR009010. Asp_de-COase-like_dom.
    IPR003190. Asp_decarbox.
    [Graphical view ]
    PANTHERi PTHR21012. PTHR21012. 1 hit.
    Pfami PF02261. Asp_decarbox. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006246. Asp_decarbox. 1 hit.
    ProDomi PD009294. Asp_decarbox. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    TIGRFAMsi TIGR00223. panD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R.
      , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: YS-314Imported.

    Entry informationi

    Entry nameiC8NRH0_COREF
    AccessioniPrimary (citable) accession number: C8NRH0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    External Data

    Dasty 3