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C8NRH0

- C8NRH0_COREF

UniProt

C8NRH0 - C8NRH0_COREF

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Protein
Aspartate 1-decarboxylase
Gene
panD, HMPREF0290_2595
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine By similarity.UniRule annotationSAAS annotations

Catalytic activityi

L-aspartate = beta-alanine + CO2.UniRule annotationSAAS annotations

Cofactori

Pyruvoyl group By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei25 – 251Schiff-base intermediate with substrate; via pyruvic acid By similarityUniRule annotation
Binding sitei57 – 571Substrate By similarityUniRule annotation
Active sitei58 – 581Proton donor By similarityUniRule annotation

GO - Molecular functioni

  1. aspartate 1-decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. alanine biosynthetic process Source: InterPro
  2. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotations, Lyase

Keywords - Biological processi

Pantothenate biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

PyruvateUniRule annotationSAAS annotations, Schiff baseUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCEFF196164:GJW8-138-MONOMER.
UniPathwayiUPA00028; UER00002.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate 1-decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation)
Alternative name(s):
Aspartate alpha-decarboxylase
Gene namesi
Name:panDUniRule annotationImported
ORF Names:HMPREF0290_2595Imported
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)Imported
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Pyruvic acid (Ser) By similarityUniRule annotation

Post-translational modificationi

Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus By similarity.UniRule annotation

Keywords - PTMi

Autocatalytic cleavageUniRule annotation, ZymogenUniRule annotation

Interactioni

Subunit structurei

Heterooctamer of four alpha and four beta subunits By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliC8NRH0.
SMRiC8NRH0. Positions 1-113.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni73 – 753Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the PanD family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0853.
KOiK01579.
OMAiELMIHIM.

Family and domain databases

HAMAPiMF_00446. PanD.
InterProiIPR009010. Asp_de-COase-like_dom.
IPR003190. Asp_decarbox.
[Graphical view]
PANTHERiPTHR21012. PTHR21012. 1 hit.
PfamiPF02261. Asp_decarbox. 1 hit.
[Graphical view]
PIRSFiPIRSF006246. Asp_decarbox. 1 hit.
ProDomiPD009294. Asp_decarbox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50692. SSF50692. 1 hit.
TIGRFAMsiTIGR00223. panD. 1 hit.

Sequencei

Sequence statusi: Complete.

C8NRH0-1 [UniParc]FASTAAdd to Basket

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MLRTILGSKI HRATVTQADL DYVGSITIDA DLVNAAGLIE GEKVAVVDIT    50
NGARIETYVI TGDAGTGSIC INGAAAHLIN PGDLVIIMSY LQATDAEARA 100
YQPNIVHVDA DNRIVALGND AGEPIPGSSL LSSRSL 136
Length:136
Mass (Da):14,098
Last modified:November 3, 2009 - v1
Checksum:i9C5042CB497CCC3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACLI01000106 Genomic DNA. Translation: EEW48818.1.
RefSeqiNP_736745.1. NC_004369.1.

Genome annotation databases

EnsemblBacteriaiEEW48818; EEW48818; HMPREF0290_2595.
GeneIDi1031997.
KEGGicef:CE0135.
PATRICi21486458. VBICorEff9312_0183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACLI01000106 Genomic DNA. Translation: EEW48818.1 .
RefSeqi NP_736745.1. NC_004369.1.

3D structure databases

ProteinModelPortali C8NRH0.
SMRi C8NRH0. Positions 1-113.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EEW48818 ; EEW48818 ; HMPREF0290_2595 .
GeneIDi 1031997.
KEGGi cef:CE0135.
PATRICi 21486458. VBICorEff9312_0183.

Phylogenomic databases

eggNOGi COG0853.
KOi K01579.
OMAi ELMIHIM.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00002 .
BioCyci CEFF196164:GJW8-138-MONOMER.

Family and domain databases

HAMAPi MF_00446. PanD.
InterProi IPR009010. Asp_de-COase-like_dom.
IPR003190. Asp_decarbox.
[Graphical view ]
PANTHERi PTHR21012. PTHR21012. 1 hit.
Pfami PF02261. Asp_decarbox. 1 hit.
[Graphical view ]
PIRSFi PIRSF006246. Asp_decarbox. 1 hit.
ProDomi PD009294. Asp_decarbox. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF50692. SSF50692. 1 hit.
TIGRFAMsi TIGR00223. panD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R.
    , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: YS-314Imported.

Entry informationi

Entry nameiC8NRH0_COREF
AccessioniPrimary (citable) accession number: C8NRH0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

External Data

Dasty 3

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