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C8NRH0 (C8NRH0_COREF) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length136 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine By similarity. HAMAP-Rule MF_00446 SAAS SAAS003190

Catalytic activity

L-aspartate = beta-alanine + CO2. HAMAP-Rule MF_00446 SAAS SAAS003190

Cofactor

Pyruvoyl group By similarity. PIRSR PIRSR006246-1 HAMAP-Rule MF_00446 SAAS SAAS003190

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1. HAMAP-Rule MF_00446 SAAS SAAS003190

Subunit structure

Heterooctamer of four alpha and four beta subunits By similarity. HAMAP-Rule MF_00446 SAAS SAAS003190

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00446 SAAS SAAS003190.

Post-translational modification

Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus By similarity. HAMAP-Rule MF_00446 PIRSR PIRSR006246-3

Sequence similarities

Belongs to the PanD family. HAMAP-Rule MF_00446

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. EMBL EEW48818.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region73 – 753Substrate binding By similarity PIRSR PIRSR006246-2 HAMAP-Rule MF_00446

Sites

Active site251Schiff-base intermediate with substrate; via pyruvic acid By similarity PIRSR PIRSR006246-1 HAMAP-Rule MF_00446
Active site581Proton donor By similarity PIRSR PIRSR006246-1 HAMAP-Rule MF_00446
Binding site571Substrate By similarity PIRSR PIRSR006246-2 HAMAP-Rule MF_00446

Amino acid modifications

Modified residue251Pyruvic acid (Ser) By similarity HAMAP-Rule MF_00446 PIRSR PIRSR006246-3

Sequences

Sequence LengthMass (Da)Tools
C8NRH0 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: 9C5042CB497CCC3D

FASTA13614,098
        10         20         30         40         50         60 
MLRTILGSKI HRATVTQADL DYVGSITIDA DLVNAAGLIE GEKVAVVDIT NGARIETYVI 

        70         80         90        100        110        120 
TGDAGTGSIC INGAAAHLIN PGDLVIIMSY LQATDAEARA YQPNIVHVDA DNRIVALGND 

       130 
AGEPIPGSSL LSSRSL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ACLI01000106 Genomic DNA. Translation: EEW48818.1.
RefSeqNP_736745.1. NC_004369.1.

3D structure databases

ProteinModelPortalC8NRH0.
SMRC8NRH0. Positions 1-113.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEEW48818; EEW48818; HMPREF0290_2595.
GeneID1031997.
KEGGcef:CE0135.
PATRIC21486458. VBICorEff9312_0183.

Phylogenomic databases

eggNOGCOG0853.
KOK01579.
OMAELMIHIM.

Enzyme and pathway databases

BioCycCEFF196164:GJW8-138-MONOMER.
UniPathwayUPA00028; UER00002.

Family and domain databases

HAMAPMF_00446. PanD.
InterProIPR009010. Asp_de-COase-like_dom.
IPR003190. Asp_decarbox.
[Graphical view]
PANTHERPTHR21012. PTHR21012. 1 hit.
PfamPF02261. Asp_decarbox. 1 hit.
[Graphical view]
PIRSFPIRSF006246. Asp_decarbox. 1 hit.
ProDomPD009294. Asp_decarbox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF50692. SSF50692. 1 hit.
TIGRFAMsTIGR00223. panD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC8NRH0_COREF
AccessionPrimary (citable) accession number: C8NRH0
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)