C8NQM8 (C8NQM8_COREF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glutamate 5-kinase EMBL EEW49071.1
EC=2.7.2.11 EMBL EEW49071.1

Gene names

Name:	proB EMBL EEW49071.1
ORF Names:	HMPREF0290_2303 EMBL EEW49071.1

Organism

Corynebacterium efficiens YS-314 EMBL EEW49071.1

Taxonomic identifier

196164 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline By similarity. SAAS SAAS011529
Catalytic activity	ATP + L-glutamate = ADP + L-glutamate 5-phosphate. SAAS SAAS011529
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. SAAS SAAS011529
Subcellular location	Cytoplasm By similarity SAAS SAAS011529.
Sequence similarities	Contains 1 PUA domain. SAAS SAAS011529

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis SAAS SAAS011529
Cellular component	Cytoplasm SAAS SAAS011529
Ligand	ATP-binding SAAS SAAS011529 Nucleotide-binding
Molecular function	Kinase SAAS SAAS011529 EMBL EEW49071.1 Transferase
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA binding Inferred from electronic annotation. Source: InterPro glutamate 5-kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C8NQM8 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: B7D97825A47AA488	FASTA	441	46,346
	10 20 30 40 50 60 MNHVTSAQPE SEPPTDEPDA VTLRDELPTP HPVSPVTGLP VTPYKQEDSI GASFPAPSPG 70 80 90 100 110 120 TEDSAAFGHE SNMRERIATA KRVVVKIGSS SLTSDEGGHT VDPNRINTIV NALQARMEAG 130 140 150 160 170 180 SDVIVVSSGS VAAGMAPLGL TTRPTDLSMK QAAAAVGQVH LMHQWGRSFA RYGRPVGQVL 190 200 210 220 230 240 LTAGDAGQRD RARNAQRTID RLRMLGVIPI VNENDTVATT GVNFGDNDRL AAIVSHLVSA 250 260 270 280 290 300 DALVLLSDVD GLFDKNPADP TARFISEVRD GNDLKGVLAG DGGKVGTGGM ASKVSAARLA 310 320 330 340 350 360 SRSGVPVLLT SAANIGPALE HAQVGTVFHP KENRLSAWKF WALYAADTAG KIRLDQGATE 370 380 390 400 410 420 AVTSGGKSLL AVGITEVIGD FRAGEIVEIL GPNGEIIGRG EVNYDSETLM PMLGMKTQEL 430 440 PDDMQRPVVH ADYLSNYASR A

References

[1]

Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R. , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R. Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: YS-314 EMBL EEW49071.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACLI01000098 Genomic DNA. Translation: EEW49071.1.
RefSeq	NP_738875.1. NC_004369.1.
3D structure databases
ProteinModelPortal	C8NQM8.
ModBase	Search...
Protein-protein interaction databases
STRING	C8NQM8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1032085.
PATRIC	21490655. VBICorEff9312_2239.
Phylogenomic databases
OMA	TFGDNDM.
ProtClustDB	PRK05429.
Family and domain databases
HAMAP	MF_00456. ProB. [Tree]
InterPro	IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. IPR011529. Glu_5kinase. IPR005715. Glu_5kinase/COase_Synthase. IPR019797. Glutamate_5-kinase_CS. IPR002478. PUA. IPR015947. PUA-like_domain. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. PF01472. PUA. 1 hit. [Graphical view]
PIRSF	PIRSF000729. GK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SMART	SM00359. PUA. 1 hit. [Graphical view]
SUPFAM	SSF53633. Aa_kinase. 1 hit. SSF88697. PUA-like. 1 hit.
TIGRFAMs	TIGR01027. ProB. 1 hit.
PROSITE	PS00902. GLUTAMATE_5_KINASE. 1 hit. PS50890. PUA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C8NQM8_COREF

Accession

Primary (citable) accession number: C8NQM8

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	December 14, 2011
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)