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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei579 – 5791UniRule annotation

GO - Molecular functioni

  1. kinase activity Source: UniProtKB-KW
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, LyaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciCEFF196164:GJW8-1732-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
ORF Names:HMPREF0290_1738Imported
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)Imported
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC8NP13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
KOiK01595.
OMAiFTSNWEL.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8NP13-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNELLRDDIR YLGRILGEVI SEQEGHHVFE LVERARRTSF DIAKGRAEMD
60 70 80 90 100
SLVEVFAGID PEDATPVARA FTHFALLANL AEDLHDAAQR EQALNSGEPA
110 120 130 140 150
PDSTLEATWV KLDDAGVGSG EVAAVIRNAL VAPVLTAHPT ETRRRTVFDA
160 170 180 190 200
QKHITALMEE RHLLLALPTH ARTQSKLDDI ERNIRRRITI LWQTALIRVA
210 220 230 240 250
RPRIEDEVEV GLRYYKLSLL AEIPRINHDV TVELARRFGG DIPTTAMVRP
260 270 280 290 300
GSWIGGDHDG NPFVTAETVT YATHRAAETV LKYYVKQLHA LEHELSLSDR
310 320 330 340 350
MNVISDELRV LADAGQNDMP SRVDEPYRRA IHGMRGRMLA TTAALIGEEA
360 370 380 390 400
VEGTWFKTFT PYTDTHEFKR DLDIVDGSLR MSRDDIIADD RLAMLRSALD
410 420 430 440 450
SFGFNLYSLD LRQNSDGFED VLTELFATAQ TEKNYRGLTE AEKLDLLIRE
460 470 480 490 500
LSTPRPLIPH GDPDYSEATN RELGIFSKAA EAVRKFGPLM VPHCIISMAS
510 520 530 540 550
SVTDILEPMV LLKEFGLIRA NGKNPTGSVD VIPLFETIDD LQRGAGILEE
560 570 580 590 600
LWDIDLYRNY LEQRDNVQEV MLGYSDSNKD GGYFAANWAL YDAELRLVEL
610 620 630 640 650
CRGRNVKLRL FHGRGGTVGR GGGPSYDAIL AQPKGAVRGA VRVTEQGEII
660 670 680 690 700
SAKYGNPDTA RRNLEALVSA TLEASLLDDV ELPNRERAHQ IMGEISELSF
710 720 730 740 750
RRYSSLVHED PGFIQYFTQS TPLQEIGSLN IGSRPSSRKQ TNTVEDLRAI
760 770 780 790 800
PWVLSWSQSR VMLPGWFGVG TALREWIGEG EGAAERIAEL QELNRCWPFF
810 820 830 840 850
TSVLDNMAQV MSKAELRLAR LYADLIPDRE VADRIYETIF GEYFLTKEMF
860 870 880 890 900
CTITGSQDLL DDNPALARSV RSRFPYLLPL NVIQVEMMRR YRSGDEGTAV
910
PRNIRLTMNG LSTALRNSG
Length:919
Mass (Da):103,096
Last modified:November 3, 2009 - v1
Checksum:iE2D8FE8DD5BC6E51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACLI01000086 Genomic DNA. Translation: EEW49676.1.
RefSeqiNP_738313.1. NC_004369.1.

Genome annotation databases

EnsemblBacteriaiEEW49676; EEW49676; HMPREF0290_1738.
GeneIDi1034200.
KEGGicef:CE1703.
PATRICi21489547. VBICorEff9312_1694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACLI01000086 Genomic DNA. Translation: EEW49676.1.
RefSeqiNP_738313.1. NC_004369.1.

3D structure databases

ProteinModelPortaliC8NP13.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEEW49676; EEW49676; HMPREF0290_1738.
GeneIDi1034200.
KEGGicef:CE1703.
PATRICi21489547. VBICorEff9312_1694.

Phylogenomic databases

eggNOGiCOG2352.
KOiK01595.
OMAiFTSNWEL.

Enzyme and pathway databases

BioCyciCEFF196164:GJW8-1732-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R.
    , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: YS-314Imported.

Entry informationi

Entry nameiC8NP13_COREF
AccessioniPrimary (citable) accession number: C8NP13
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: February 4, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.