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C8NMB3

- C8NMB3_COREF

UniProt

C8NMB3 - C8NMB3_COREF

Protein

Alanine racemase

Gene

alr

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei131 – 1311SubstrateUniRule annotation
    Active sitei258 – 2581Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei306 – 3061Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCEFF196164:GJW8-606-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    ORF Names:HMPREF0290_1138Imported
    OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)Imported
    Taxonomic identifieri196164 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliC8NMB3.
    SMRiC8NMB3. Positions 1-362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    KOiK01775.
    OMAiDPFDAPI.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C8NMB3-1 [UniParc]FASTAAdd to Basket

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    MNLLTTRIDL DAIAHNTRLL KNRVGAAKLM AVVKADGYNH GMDRVAPVMA    50
    ANGADAFGVA TIAEALALRA TGITTPILCW IWSPEQDWAA AVEAGIDLAV 100
    ISPRHARVLV DAPPTSRAIR VSVKVDTALH RSGVDEQDWD AVFTLLRDCG 150
    HIEVTGLFTH LSCADEPGNP ETDHQAETFR RAIDRARALG LEVPENHLCN 200
    SPATLTRPDL HMDMVRPGVA LYGLEPIPGL DHGLRPAMTW AGAITVVKPI 250
    RKGEGTSYGL TWRAEADGFV AVVPAGYADG VPRAAQDHLR VHVNGHDYPQ 300
    VGRVCMDQFV IFLGDNPHGV TAGDEAVIFG GTGMSATELA DALATINYEV 350
    ICRPTGRTVR DYTGEGK 367
    Length:367
    Mass (Da):39,352
    Last modified:November 3, 2009 - v1
    Checksum:iB07005E2CF893D6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACLI01000057 Genomic DNA. Translation: EEW50253.1.
    RefSeqiNP_737203.1. NC_004369.1.

    Genome annotation databases

    EnsemblBacteriaiEEW50253; EEW50253; HMPREF0290_1138.
    GeneIDi1034900.
    KEGGicef:CE0593.
    PATRICi21487356. VBICorEff9312_0620.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACLI01000057 Genomic DNA. Translation: EEW50253.1 .
    RefSeqi NP_737203.1. NC_004369.1.

    3D structure databases

    ProteinModelPortali C8NMB3.
    SMRi C8NMB3. Positions 1-362.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EEW50253 ; EEW50253 ; HMPREF0290_1138 .
    GeneIDi 1034900.
    KEGGi cef:CE0593.
    PATRICi 21487356. VBICorEff9312_0620.

    Phylogenomic databases

    eggNOGi COG0787.
    KOi K01775.
    OMAi DPFDAPI.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci CEFF196164:GJW8-606-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R.
      , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: YS-314Imported.

    Entry informationi

    Entry nameiC8NMB3_COREF
    AccessioniPrimary (citable) accession number: C8NMB3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    External Data

    Dasty 3