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Protein
Submitted name:

7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)

Gene

SAMG_02376

Organism
Staphylococcus aureus A9719
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: InterPro
  2. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)Imported
Gene namesi
ORF Names:SAMG_02376Imported
OrganismiStaphylococcus aureus A9719Imported
Taxonomic identifieri553588 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AD6X-ray1.85A/B1-158[»]
ProteinModelPortaliC8MLE4.
SMRiC8MLE4. Positions 1-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.30.70.560. 1 hit.
InterProiIPR000550. Hppk.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiPS00794. HPPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8MLE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQAYLGLGS NIGDRESQLN DAIKILNEYD GISVSNISPI YETAPVGYTE
60 70 80 90 100
QPNFLNLCVE IQTTLTVLQL LECCLKTEEC LHRIRKERWG PRTLDVDILL
110 120 130 140 150
YGEEMIDLPK LSVPHPRMNE RAFVLIPLND IAANVVEPRS KLKVKDLVFV

DDSVKRYK
Length:158
Mass (Da):18,002
Last modified:November 3, 2009 - v1
Checksum:iC029E324C16690C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACKJ01000034 Genomic DNA. Translation: EEV67598.1.

Genome annotation databases

EnsemblBacteriaiEEV67598; EEV67598; SAMG_02376.
PATRICi26186395. VBIStaAur45793_1112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACKJ01000034 Genomic DNA. Translation: EEV67598.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AD6X-ray1.85A/B1-158[»]
ProteinModelPortaliC8MLE4.
SMRiC8MLE4. Positions 1-158.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEEV67598; EEV67598; SAMG_02376.
PATRICi26186395. VBIStaAur45793_1112.

Family and domain databases

Gene3Di3.30.70.560. 1 hit.
InterProiIPR000550. Hppk.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiPS00794. HPPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A9719Imported.
  2. "Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK."
    Chhabra S., Barlow N., Dolezal O., Hattarki M.K., Newman J., Peat T.S., Graham B., Swarbrick J.D.
    PLoS ONE 8:e59535-e59535(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).

Entry informationi

Entry nameiC8MLE4_STAAU
AccessioniPrimary (citable) accession number: C8MLE4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: January 7, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.