Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C8MLE4

- C8MLE4_STAAU

UniProt

C8MLE4 - C8MLE4_STAAU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)

Gene

SAMG_02376

Organism
Staphylococcus aureus A9719
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: InterPro
  2. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)Imported
Gene namesi
ORF Names:SAMG_02376Imported
OrganismiStaphylococcus aureus A9719Imported
Taxonomic identifieri553588 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AD6X-ray1.85A/B1-158[»]
ProteinModelPortaliC8MLE4.
SMRiC8MLE4. Positions 1-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.30.70.560. 1 hit.
InterProiIPR000550. Hppk.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiPS00794. HPPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8MLE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQAYLGLGS NIGDRESQLN DAIKILNEYD GISVSNISPI YETAPVGYTE
60 70 80 90 100
QPNFLNLCVE IQTTLTVLQL LECCLKTEEC LHRIRKERWG PRTLDVDILL
110 120 130 140 150
YGEEMIDLPK LSVPHPRMNE RAFVLIPLND IAANVVEPRS KLKVKDLVFV

DDSVKRYK
Length:158
Mass (Da):18,002
Last modified:November 3, 2009 - v1
Checksum:iC029E324C16690C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACKJ01000034 Genomic DNA. Translation: EEV67598.1.

Genome annotation databases

EnsemblBacteriaiEEV67598; EEV67598; SAMG_02376.
PATRICi26186395. VBIStaAur45793_1112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACKJ01000034 Genomic DNA. Translation: EEV67598.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AD6 X-ray 1.85 A/B 1-158 [» ]
ProteinModelPortali C8MLE4.
SMRi C8MLE4. Positions 1-158.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EEV67598 ; EEV67598 ; SAMG_02376 .
PATRICi 26186395. VBIStaAur45793_1112.

Family and domain databases

Gene3Di 3.30.70.560. 1 hit.
InterProi IPR000550. Hppk.
[Graphical view ]
Pfami PF01288. HPPK. 1 hit.
[Graphical view ]
SUPFAMi SSF55083. SSF55083. 1 hit.
TIGRFAMsi TIGR01498. folK. 1 hit.
PROSITEi PS00794. HPPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A9719Imported.
  2. "Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK."
    Chhabra S., Barlow N., Dolezal O., Hattarki M.K., Newman J., Peat T.S., Graham B., Swarbrick J.D.
    PLoS ONE 8:e59535-e59535(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).

Entry informationi

Entry nameiC8MLE4_STAAU
AccessioniPrimary (citable) accession number: C8MLE4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3