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C8MLE4

- C8MLE4_STAAU

UniProt

C8MLE4 - C8MLE4_STAAU

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Protein
Submitted name: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
Gene
SAMG_02376
Organism
Staphylococcus aureus A9719
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: InterPro
  2. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)Imported
Gene namesi
ORF Names:SAMG_02376Imported
OrganismiStaphylococcus aureus A9719Imported
Taxonomic identifieri553588 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AD6X-ray1.85A/B1-158[»]
ProteinModelPortaliC8MLE4.
SMRiC8MLE4. Positions 1-158.

Family & Domainsi

Family and domain databases

Gene3Di3.30.70.560. 1 hit.
InterProiIPR000550. Hppk.
[Graphical view]
PfamiPF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiPS00794. HPPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C8MLE4-1 [UniParc]FASTAAdd to Basket

« Hide

MIQAYLGLGS NIGDRESQLN DAIKILNEYD GISVSNISPI YETAPVGYTE    50
QPNFLNLCVE IQTTLTVLQL LECCLKTEEC LHRIRKERWG PRTLDVDILL 100
YGEEMIDLPK LSVPHPRMNE RAFVLIPLND IAANVVEPRS KLKVKDLVFV 150
DDSVKRYK 158
Length:158
Mass (Da):18,002
Last modified:November 3, 2009 - v1
Checksum:iC029E324C16690C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACKJ01000034 Genomic DNA. Translation: EEV67598.1.

Genome annotation databases

EnsemblBacteriaiEEV67598; EEV67598; SAMG_02376.
PATRICi26186395. VBIStaAur45793_1112.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACKJ01000034 Genomic DNA. Translation: EEV67598.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AD6 X-ray 1.85 A/B 1-158 [» ]
ProteinModelPortali C8MLE4.
SMRi C8MLE4. Positions 1-158.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EEV67598 ; EEV67598 ; SAMG_02376 .
PATRICi 26186395. VBIStaAur45793_1112.

Family and domain databases

Gene3Di 3.30.70.560. 1 hit.
InterProi IPR000550. Hppk.
[Graphical view ]
Pfami PF01288. HPPK. 1 hit.
[Graphical view ]
SUPFAMi SSF55083. SSF55083. 1 hit.
TIGRFAMsi TIGR01498. folK. 1 hit.
PROSITEi PS00794. HPPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A9719Imported.
  2. "Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK."
    Chhabra S., Barlow N., Dolezal O., Hattarki M.K., Newman J., Peat T.S., Graham B., Swarbrick J.D.
    PLoS ONE 8:e59535-e59535(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).

Entry informationi

Entry nameiC8MLE4_STAAU
AccessioniPrimary (citable) accession number: C8MLE4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: April 16, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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