Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C8MLE4

- C8MLE4_STAAU

UniProt

C8MLE4 - C8MLE4_STAAU

Protein
Submitted name:

7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)

Gene

SAMG_02376

Organism
Staphylococcus aureus A9719
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: InterPro
    2. kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)Imported
    Gene namesi
    ORF Names:SAMG_02376Imported
    OrganismiStaphylococcus aureus A9719Imported
    Taxonomic identifieri553588 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AD6X-ray1.85A/B1-158[»]
    ProteinModelPortaliC8MLE4.
    SMRiC8MLE4. Positions 1-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di3.30.70.560. 1 hit.
    InterProiIPR000550. Hppk.
    [Graphical view]
    PfamiPF01288. HPPK. 1 hit.
    [Graphical view]
    SUPFAMiSSF55083. SSF55083. 1 hit.
    TIGRFAMsiTIGR01498. folK. 1 hit.
    PROSITEiPS00794. HPPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C8MLE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIQAYLGLGS NIGDRESQLN DAIKILNEYD GISVSNISPI YETAPVGYTE    50
    QPNFLNLCVE IQTTLTVLQL LECCLKTEEC LHRIRKERWG PRTLDVDILL 100
    YGEEMIDLPK LSVPHPRMNE RAFVLIPLND IAANVVEPRS KLKVKDLVFV 150
    DDSVKRYK 158
    Length:158
    Mass (Da):18,002
    Last modified:November 3, 2009 - v1
    Checksum:iC029E324C16690C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACKJ01000034 Genomic DNA. Translation: EEV67598.1.

    Genome annotation databases

    EnsemblBacteriaiEEV67598; EEV67598; SAMG_02376.
    PATRICi26186395. VBIStaAur45793_1112.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACKJ01000034 Genomic DNA. Translation: EEV67598.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AD6 X-ray 1.85 A/B 1-158 [» ]
    ProteinModelPortali C8MLE4.
    SMRi C8MLE4. Positions 1-158.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EEV67598 ; EEV67598 ; SAMG_02376 .
    PATRICi 26186395. VBIStaAur45793_1112.

    Family and domain databases

    Gene3Di 3.30.70.560. 1 hit.
    InterProi IPR000550. Hppk.
    [Graphical view ]
    Pfami PF01288. HPPK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55083. SSF55083. 1 hit.
    TIGRFAMsi TIGR01498. folK. 1 hit.
    PROSITEi PS00794. HPPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: A9719Imported.
    2. "Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK."
      Chhabra S., Barlow N., Dolezal O., Hattarki M.K., Newman J., Peat T.S., Graham B., Swarbrick J.D.
      PLoS ONE 8:e59535-e59535(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).

    Entry informationi

    Entry nameiC8MLE4_STAAU
    AccessioniPrimary (citable) accession number: C8MLE4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3