C8MLE4 (C8MLE4_STAAU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) EMBL EEV67598.1

Gene names

ORF Names:

SAMG_02376 EMBL EEV67598.1

Organism

Staphylococcus aureus A9719 EMBL EEV67598.1

Taxonomic identifier

553588 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Ontologies

Keywords
Molecular function	Kinase EMBL EEV67598.1 Transferase
Technical term	3D-structure PDB 4AD6
Gene Ontology (GO)
Biological_process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Inferred from electronic annotation. Source: InterPro kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C8MLE4 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: C029E324C16690C0	FASTA	158	18,002
	10 20 30 40 50 60 MIQAYLGLGS NIGDRESQLN DAIKILNEYD GISVSNISPI YETAPVGYTE QPNFLNLCVE 70 80 90 100 110 120 IQTTLTVLQL LECCLKTEEC LHRIRKERWG PRTLDVDILL YGEEMIDLPK LSVPHPRMNE 130 140 150 RAFVLIPLND IAANVVEPRS KLKVKDLVFV DDSVKRYK

References

[1]	"The Genome Sequence of Staphylococcus aureus strain A9719." The Broad Institute Genome Sequencing Platform Ward D., Young S.K., Zeng Q., Koehrsen M., Godfrey P., Alvarado L., Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C. , Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Peleg A.Y., Galagan J., Nusbaum C., Birren B. Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A9719 EMBL EEV67598.1.
[2]	"Synthesis and Sar Study of Guanine Based Analogues for Hppk Inhibitors." Chhabra S., Peat T.S., Swarbrick J. Submitted (DEC-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

ACKJ01000034 Genomic DNA. Translation: EEV67598.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4AD6	X-ray	1.85	A/B	1-158	[»]

ProteinModelPortal

C8MLE4.

SMR

C8MLE4. Positions 1-158.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EEV67598; EEV67598; SAMG_02376.

PATRIC

26186395. VBIStaAur45793_1112.

Family and domain databases

Gene3D

3.30.70.560. 1 hit.

InterPro

IPR000550. Hppk.
[Graphical view]

Pfam

PF01288. HPPK. 1 hit.
[Graphical view]

SUPFAM

SSF55083. Hppk. 1 hit.

TIGRFAMs

TIGR01498. folK. 1 hit.

PROSITE

PS00794. HPPK. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

C8MLE4_STAAU

Accession

Primary (citable) accession number: C8MLE4

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	May 29, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)