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C8MK44

- C8MK44_STAAU

UniProt

C8MK44 - C8MK44_STAAU

Protein
Submitted name:

Phosphomethylpyrimidine kinase

Gene

SAMG_02176

Organism
Staphylococcus aureus A9719
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei176 – 1761ATPanalogImported
    Binding sitei238 – 2381ATPanalogImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi186 – 1883ATPanalogImported
    Nucleotide bindingi203 – 2042ATPanalogImported
    Nucleotide bindingi209 – 2146ATPanalogImported

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphomethylpyrimidine kinase activity Source: InterPro

    GO - Biological processi

    1. thiamine biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    KinaseSAAS annotationImported, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Phosphomethylpyrimidine kinaseImported
    Gene namesi
    ORF Names:SAMG_02176Imported
    OrganismiStaphylococcus aureus A9719Imported
    Taxonomic identifieri553588 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4C5NX-ray1.75A/B/C/D2-276[»]
    ProteinModelPortaliC8MK44.
    SMRiC8MK44. Positions 2-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    InterProiIPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF08543. Phos_pyr_kin. 1 hit.
    [Graphical view]
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C8MK44-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALKKVLTIA GSDTSAGAGM QADLKTFQEL DTYGMVALTA IVTMDKDTWS    50
    HDVTPLPMDV FEKQLETALS IGPDAIKTGM LGTEEIIKRA GEVYEASNAQ 100
    YFVVDPVMVC KGEDEVLNPG NTEAMIKYLL PKATVVTPNL FEAGQLSGLG 150
    KLNSIEDMKK AATIIFDKGA QHVIIKGGKA LDQDKSYDLY YDGQTFYQLT 200
    TDMFQQSYNH GAGCTFAAAT TAYLANGKSP KEAVISAKAF VASAIKNGWK 250
    MNDFVGPVDH GAYNRIEHID VEVTEV 276
    Length:276
    Mass (Da):29,857
    Last modified:November 3, 2009 - v1
    Checksum:i62C5F054E4D56779
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACKJ01000025 Genomic DNA. Translation: EEV68052.1.

    Genome annotation databases

    EnsemblBacteriaiEEV68052; EEV68052; SAMG_02176.
    PATRICi26185442. VBIStaAur45793_0658.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACKJ01000025 Genomic DNA. Translation: EEV68052.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4C5N X-ray 1.75 A/B/C/D 2-276 [» ]
    ProteinModelPortali C8MK44.
    SMRi C8MK44. Positions 2-276.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EEV68052 ; EEV68052 ; SAMG_02176 .
    PATRICi 26185442. VBIStaAur45793_0658.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    InterProi IPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF08543. Phos_pyr_kin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: A9719Imported.
    2. "A subfamily of bacterial ribokinases utilizes a hemithioacetal for pyridoxal phosphate salvage."
      Nodwell M.B., Koch M.F., Alte F., Schneider S., Sieber S.A.
      J. Am. Chem. Soc. 136:4992-4999(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 2-276 IN COMPLEX WITH ATPANALOG.

    Entry informationi

    Entry nameiC8MK44_STAAU
    AccessioniPrimary (citable) accession number: C8MK44
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3