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C8MK44

- C8MK44_STAAU

UniProt

C8MK44 - C8MK44_STAAU

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Protein
Submitted name: Phosphomethylpyrimidine kinase
Gene
SAMG_02176
Organism
Staphylococcus aureus A9719
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei223 – 2231Sulfate 1Imported
Binding sitei263 – 2631Sulfate 1Imported

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphomethylpyrimidine kinase activity Source: InterPro

GO - Biological processi

  1. thiamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationsImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphomethylpyrimidine kinaseImported
Gene namesi
ORF Names:SAMG_02176Imported
OrganismiStaphylococcus aureus A9719Imported
Taxonomic identifieri553588 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C5NX-ray1.75A/B/C/D2-276[»]
ProteinModelPortaliC8MK44.
SMRiC8MK44. Positions 2-276.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni206 – 2072Sulfate 2 bindingImported

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

C8MK44-1 [UniParc]FASTAAdd to Basket

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MALKKVLTIA GSDTSAGAGM QADLKTFQEL DTYGMVALTA IVTMDKDTWS    50
HDVTPLPMDV FEKQLETALS IGPDAIKTGM LGTEEIIKRA GEVYEASNAQ 100
YFVVDPVMVC KGEDEVLNPG NTEAMIKYLL PKATVVTPNL FEAGQLSGLG 150
KLNSIEDMKK AATIIFDKGA QHVIIKGGKA LDQDKSYDLY YDGQTFYQLT 200
TDMFQQSYNH GAGCTFAAAT TAYLANGKSP KEAVISAKAF VASAIKNGWK 250
MNDFVGPVDH GAYNRIEHID VEVTEV 276
Length:276
Mass (Da):29,857
Last modified:November 3, 2009 - v1
Checksum:i62C5F054E4D56779
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACKJ01000025 Genomic DNA. Translation: EEV68052.1.

Genome annotation databases

EnsemblBacteriaiEEV68052; EEV68052; SAMG_02176.
PATRICi26185442. VBIStaAur45793_0658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACKJ01000025 Genomic DNA. Translation: EEV68052.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4C5N X-ray 1.75 A/B/C/D 2-276 [» ]
ProteinModelPortali C8MK44.
SMRi C8MK44. Positions 2-276.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EEV68052 ; EEV68052 ; SAMG_02176 .
PATRICi 26185442. VBIStaAur45793_0658.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
InterProi IPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF08543. Phos_pyr_kin. 1 hit.
[Graphical view ]
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A9719Imported.
  2. "A subfamily of bacterial ribokinases utilizes a hemithioacetal for pyridoxal phosphate salvage."
    Nodwell M.B., Koch M.F., Alte F., Schneider S., Sieber S.A.
    J. Am. Chem. Soc. 136:4992-4999(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 2-276.

Entry informationi

Entry nameiC8MK44_STAAU
AccessioniPrimary (citable) accession number: C8MK44
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 3, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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