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C8MK44

- C8MK44_STAAU

UniProt

C8MK44 - C8MK44_STAAU

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Protein
Submitted name:

Phosphomethylpyrimidine kinase

Gene

SAMG_02176

Organism
Staphylococcus aureus A9719
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei176 – 1761ATPanalogImported
Binding sitei238 – 2381ATPanalogImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi186 – 1883ATPanalogImported
Nucleotide bindingi203 – 2042ATPanalogImported
Nucleotide bindingi209 – 2146ATPanalogImported

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphomethylpyrimidine kinase activity Source: InterPro

GO - Biological processi

  1. thiamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphomethylpyrimidine kinaseImported
Gene namesi
ORF Names:SAMG_02176Imported
OrganismiStaphylococcus aureus A9719Imported
Taxonomic identifieri553588 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C5NX-ray1.75A/B/C/D2-276[»]
ProteinModelPortaliC8MK44.
SMRiC8MK44. Positions 2-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

C8MK44-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALKKVLTIA GSDTSAGAGM QADLKTFQEL DTYGMVALTA IVTMDKDTWS
60 70 80 90 100
HDVTPLPMDV FEKQLETALS IGPDAIKTGM LGTEEIIKRA GEVYEASNAQ
110 120 130 140 150
YFVVDPVMVC KGEDEVLNPG NTEAMIKYLL PKATVVTPNL FEAGQLSGLG
160 170 180 190 200
KLNSIEDMKK AATIIFDKGA QHVIIKGGKA LDQDKSYDLY YDGQTFYQLT
210 220 230 240 250
TDMFQQSYNH GAGCTFAAAT TAYLANGKSP KEAVISAKAF VASAIKNGWK
260 270
MNDFVGPVDH GAYNRIEHID VEVTEV
Length:276
Mass (Da):29,857
Last modified:November 3, 2009 - v1
Checksum:i62C5F054E4D56779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACKJ01000025 Genomic DNA. Translation: EEV68052.1.

Genome annotation databases

EnsemblBacteriaiEEV68052; EEV68052; SAMG_02176.
PATRICi26185442. VBIStaAur45793_0658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACKJ01000025 Genomic DNA. Translation: EEV68052.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4C5N X-ray 1.75 A/B/C/D 2-276 [» ]
ProteinModelPortali C8MK44.
SMRi C8MK44. Positions 2-276.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EEV68052 ; EEV68052 ; SAMG_02176 .
PATRICi 26185442. VBIStaAur45793_0658.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
InterProi IPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF08543. Phos_pyr_kin. 1 hit.
[Graphical view ]
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A9719Imported.
  2. "A subfamily of bacterial ribokinases utilizes a hemithioacetal for pyridoxal phosphate salvage."
    Nodwell M.B., Koch M.F., Alte F., Schneider S., Sieber S.A.
    J. Am. Chem. Soc. 136:4992-4999(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 2-276 IN COMPLEX WITH ATPANALOG.

Entry informationi

Entry nameiC8MK44_STAAU
AccessioniPrimary (citable) accession number: C8MK44
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: October 1, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3