C8L8V9 (C8L8V9_STAAU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Protein ArsC HAMAP MF_01624

Alternative name(s):
Arsenate reductase HAMAP MF_01624
Arsenical pump modifier HAMAP MF_01624
Low molecular weight protein-tyrosine-phosphatase HAMAP MF_01624

Gene names

Name:	arsC HAMAP MF_01624
ORF Names:	SAGG_02519 EMBL EEV84272.1

Organism

Staphylococcus aureus A5948 EMBL EEV84272.1

Taxonomic identifier

553567 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity. HAMAP MF_01624
Catalytic activity	Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O. HAMAP MF_01624 Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. HAMAP MF_01624
Subunit structure	Monomer By similarity. HAMAP MF_01624
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family. HAMAP MF_01624
Caution	The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Ontologies

Keywords
Biological process	Arsenical resistance HAMAP MF_01624
Domain	Redox-active center HAMAP MF_01624
Molecular function	Hydrolase HAMAP MF_01624 SAAS SAAS023485 Oxidoreductase HAMAP MF_01624
PTM	Disulfide bond HAMAP MF_01624
Gene Ontology (GO)
Biological process	response to arsenic-containing substance Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arsenate reductase (thioredoxin) activity Inferred from electronic annotation. Source: HAMAP protein tyrosine phosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	10	1	Nucleophile; for reductase activity and phosphatase activity By similarity HAMAP MF_01624
	Active site	82	1	Nucleophile; for reductase activity By similarity HAMAP MF_01624
	Active site	89	1	Nucleophile; for reductase activity By similarity HAMAP MF_01624
Amino acid modifications
	Disulfide bond	10 ↔ 82		Redox-active; alternate By similarity HAMAP MF_01624
	Disulfide bond	82 ↔ 89		Redox-active; alternate By similarity HAMAP MF_01624

Sequences

	Sequence		Length	Mass (Da)
	C8L8V9 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: 9B6AA5A854D66C89	FASTA	131	14,687
	10 20 30 40 50 60 MTKKTIYFIC TGNSCRSQMA EGWAKQILAD DWNVYSAGIE THGVNPKAIE AMKEVGIDIS 70 80 90 100 110 120 NHTSDLIDNN IIKNSNLVVT LCSDADVNCP SLPTNVKKEH WGFDDPAGKP WSEFQRVRDE 130 IKIAIENFKS R

References

[1]

"The Genome Sequence of Staphylococcus aureus strain A5948." The Broad Institute Genome Sequencing Platform Ward D., Young S.K., Zeng Q., Koehrsen M., Godfrey P., Alvarado L., Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C. , Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Peleg A.Y., Galagan J., Nusbaum C., Birren B. Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A5948 EMBL EEV84272.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACKD01000007 Genomic DNA. Translation: EEV84272.1.
3D structure databases
ProteinModelPortal	C8L8V9.
SMR	C8L8V9. Positions 3-131.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	29472282. VBIStaAur101774_0340.
Family and domain databases
HAMAP	MF_01624. Arsenate_reduct. [Tree]
InterPro	IPR014064. Arsenate_reductase_ArsC. IPR023485. Ptyr_pPase_SF. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. Low_mwt_PTPase. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
TIGRFAMs	TIGR02691. ArsC_pI258_fam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C8L8V9_STAAU

Accession

Primary (citable) accession number: C8L8V9

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	December 14, 2011
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)