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C8KJ11 (C8KJ11_STAAU) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase 1 HAMAP MF_00488
Short name=L-LDH 1 HAMAP MF_00488
EC=1.1.1.27 HAMAP MF_00488
Gene names
Name:lctE EMBL EEW46014.1
Synonyms:ldh1 HAMAP MF_00488
ORF Names:SA930_0673 EMBL EEW46014.1
OrganismStaphylococcus aureus 930918-3 EMBL EEW46014.1
Taxonomic identifier452948 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-lactate + NAD+ = pyruvate + NADH. HAMAP MF_00488

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. HAMAP MF_00488

Subunit structure

Homotetramer By similarity. HAMAP MF_00488

Subcellular location

Cytoplasm By similarity HAMAP MF_00488.

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family. HAMAP MF_00488

Ontologies

Keywords
   Biological processGlycolysis HAMAP MF_00488
Stress response HAMAP MF_00488
   Cellular componentCytoplasm HAMAP MF_00488
   LigandNAD HAMAP MF_00488
   Molecular functionOxidoreductase HAMAP MF_00488
   PTMPhosphoprotein HAMAP MF_00488
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: HAMAP

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-lactate dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding15 – 4329NAD By similarity HAMAP MF_00488

Sites

Active site1791Proton acceptor By similarity HAMAP MF_00488
Binding site921Substrate By similarity HAMAP MF_00488
Binding site1241NAD or substrate By similarity HAMAP MF_00488
Binding site1551Substrate By similarity HAMAP MF_00488
Binding site2321Substrate By similarity HAMAP MF_00488

Amino acid modifications

Modified residue2231Phosphotyrosine By similarity HAMAP MF_00488

Sequences

Sequence LengthMass (Da)Tools
C8KJ11 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: CDDE481269B7DE56

FASTA31734,583
        10         20         30         40         50         60 
MNKFKGNKVV LIGNGAVGSS YAFSLVNQSI VDELVIIDLD TEKVRGDVMD LKHATPYSPT 

        70         80         90        100        110        120 
TVRVKAGEYS DCHDADLVVI CAGAAQKPGE TRLDLVSKNL KIFKSIVGEV MASKFDGIFL 

       130        140        150        160        170        180 
VATNPVDILA YATWKFSGLP KERVIGSGTI LDSARFRLLL SEAFDVAPRS VDAQIIGEHG 

       190        200        210        220        230        240 
DTELPVWSHA NIAGQPLKTL LEQRPEGKAQ IEQIFVQTRD AAYDIIQAKG ATYYGVAMGL 

       250        260        270        280        290        300 
ARITEAIFRN EDAVLTVSAL LEGEYEEEDV YIGVPAVINR NGIRNVVEIP LNDEEQSKFA 

       310 
HSAKTLKDIM AEAEELK

« Hide

References

[1]"Genome sequencing and analysis reveals possible determinants of Staphylococcus aureus nasal carriage."
Sivaraman K., Venkataraman N., Tsai J., Dewell S., Cole A.M.
BMC Genomics 9:433-433(2008) [PubMed: 18808706] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 930918-3 EMBL EEW46014.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		ABFA01000001 Genomic DNA. Translation: EEW46014.1.

3D structure databases

ProteinModelPortalC8KJ11.
SMRC8KJ11. Positions 1-313.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC35523831. VBIStaAur16924_0088.

Family and domain databases

HAMAPMF_00488. Lactate_dehydrog.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11540:SF3. PTHR11540:SF3. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01771. L-LDH-NAD. 1 hit.
PROSITEPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC8KJ11_STAAU
AccessionPrimary (citable) accession number: C8KJ11
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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