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C8K917 (C8K917_LISMO) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase 1 HAMAP MF_00488
Short name=L-LDH 1 HAMAP MF_00488
EC=1.1.1.27 HAMAP MF_00488
Gene names
Name:ldh1 HAMAP MF_00488
ORF Names:LMMG_00499 EMBL EEW21738.1
OrganismListeria monocytogenes F6900 EMBL EEW21738.1
Taxonomic identifier393128 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-lactate + NAD+ = pyruvate + NADH. HAMAP MF_00488

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. HAMAP MF_00488

Subunit structure

Homotetramer By similarity. HAMAP MF_00488

Subcellular location

Cytoplasm By similarity HAMAP MF_00488.

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family. HAMAP MF_00488

Ontologies

Keywords
   Biological processGlycolysis HAMAP MF_00488
   Cellular componentCytoplasm HAMAP MF_00488
   LigandNAD HAMAP MF_00488
   Molecular functionOxidoreductase HAMAP MF_00488
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-lactate dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 4029NAD By similarity HAMAP MF_00488

Sites

Active site1771Proton acceptor By similarity HAMAP MF_00488
Binding site901Substrate By similarity HAMAP MF_00488
Binding site1221NAD or substrate By similarity HAMAP MF_00488
Binding site1531Substrate By similarity HAMAP MF_00488
Binding site2301Substrate By similarity HAMAP MF_00488

Sequences

Sequence LengthMass (Da)Tools
C8K917 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: D7DB065307C8E301

FASTA31133,741
        10         20         30         40         50         60 
MKPRKVMIIG AGNVGTAAAH AFVNQKFVEE LILVDLNKER VEGNRKDLAD AAAFMPGKMD 

        70         80         90        100        110        120 
ITVRDASDCA DVDIAVITVT AGPLKEGQTR LDELRSTSRI VSGIVPEMMK GGFNGIFLIA 

       130        140        150        160        170        180 
TNPCDIITYQ VWKLSGLPRE RVLGTGVWLD TTRLRRLLAE KLDIAAQSID AFILGEHGDS 

       190        200        210        220        230        240 
QFPVWSHSSI YGKPVNEYSL EKLGESLDLK QIGETARDTG FEIYHQKGCT EYGIGGTIVE 

       250        260        270        280        290        300 
ICRHIFSGSQ RALTVSCVLD GEYGESGLAI GVPAVLSQNG VKEIISLKLD EQEQQAFANS 

       310 
VSVIKKSIAS I

« Hide

References

[1]"The genome sequence of Listeria monocytogenes strain F6900."
The Broad Institute Genome Sequencing Platform
Borowsky M., Young S., Jaffe D., Gnerre S., Berlin A., Heiman D., Hepburn T., Sykes S., Alvarado L., Kodira C.D., Wiedmann M., Swaminathan B., Lauer P., Portnoy D., Cossart P., Buchrieser C., Higgins D., Lander E. expand/collapse author list , Galagan J., Nusbaum C., Birren B.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: F6900 EMBL EEW21738.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AARU02000001 Genomic DNA. Translation: EEW21738.1.

3D structure databases

ProteinModelPortalC8K917.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC27480214. VBILisMon69349_1083.

Phylogenomic databases

OMANEYSMEK.

Family and domain databases

HAMAPMF_00488. Lactate_dehydrog.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11540:SF3. PTHR11540:SF3. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01771. L-LDH-NAD. 1 hit.
PROSITEPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC8K917_LISMO
AccessionPrimary (citable) accession number: C8K917
Entry history
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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