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Protein
Submitted name:

Polyprotein

Gene
N/A
Organism
Coxsackievirus A16
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation, Nucleotidyltransferase, RNA-directed RNA polymeraseSAAS annotation, Transferase

Keywords - Biological processi

Viral RNA replicationSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Protein family/group databases

MEROPSiC03.014.

Names & Taxonomyi

Protein namesi
Submitted name:
PolyproteinImported
OrganismiCoxsackievirus A16Imported
Taxonomic identifieri31704 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stagePicornaviralesPicornaviridaeEnterovirusEnterovirus A

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SJ8X-ray2.20A1-183[»]
3SJ9X-ray2.40A1-183[»]
3SJIX-ray1.80A1-183[»]
ProteinModelPortaliC8CIL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini410 – 526117RdRp catalyticInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotation

Family and domain databases

InterProiIPR000199. Peptidase_C3A/C3B_picornavir.
IPR009003. Peptidase_S1_PA.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00548. Peptidase_C3. 1 hit.
PF00680. RdRP_1. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

C8CIL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GPSLDFALSL LRRNIRQVQT DQGHFTMLGV RDRLAILPRH SQPGKTIWVE
60 70 80 90 100
HKLINVLDAV ELVDEQGVNL ELTLVTLDTN EKFRDVTKFI PETITGASDA
110 120 130 140 150
TLIINTEHMP SMFVPVGDVV QYGFLNLSGK PTHRTMMYNF PTKAGQCGGV
160 170 180 190 200
VTSVGKIIGI HIGGNGRQGF CAGLKRGYFA SEQGEIQWMK SNKETGRLNI
210 220 230 240 250
NGPTRTKLEP SAFYDVFEGS KEPAVLTSKD PRLEVDFEQA LFSKYVGNTL
260 270 280 290 300
HEPDEYVTQA ALHYANQLKQ LDININKMSM EEACYGTEYL EAINLHTSAG
310 320 330 340 350
YPYSALGVKK SDILDPTTRD TTKMKFYMDK YGLDLPYSTY VKDELRSLDK
360 370 380 390 400
IKKGKSRLIE ASSLNDSVYL RMTFGHLYET FHANPGTVTG SAVGCNPDVF
410 420 430 440 450
WSKLPILLPG SLFAFDYSGY DASLSPVWFR ALEVVLREIG YSEEAVSLIE
460 470 480 490 500
GINHTHHVYR NRTYCVLGGM PSGCSGTSIF NSMINNIIIR TLLIKTFKGI
510 520 530 540 550
DLDELNMVAY GDDVLASYPF PIDCSELAKT GKEYGLTMTP ADKSPCFNGV
560 570 580 590 600
TWENATFLKR GFLPDHQFPF LIHPTMPMRE IHESIRWTKD ARNTQDHVRS
610 620 630 640
LCLLAWHNGK EEYEKFVSTI RSVPVGKALA IPNFENLRRN WLELF
Length:645
Mass (Da):72,477
Last modified:October 13, 2009 - v1
Checksum:i7CB783B17C8D1E25
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei645 – 6451Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ406341 Genomic RNA. Translation: ACV33372.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ406341 Genomic RNA. Translation: ACV33372.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SJ8X-ray2.20A1-183[»]
3SJ9X-ray2.40A1-183[»]
3SJIX-ray1.80A1-183[»]
ProteinModelPortaliC8CIL7.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC03.014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000199. Peptidase_C3A/C3B_picornavir.
IPR009003. Peptidase_S1_PA.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00548. Peptidase_C3. 1 hit.
PF00680. RdRP_1. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and Sequence Analysis of Coxsackievirus A16 in China."
    Zhao Z., Liu X., Wang X.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Beijing0907Imported.
  2. "Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design."
    Lu G., Qi J., Chen Z., Xu X., Gao F., Lin D., Qian W., Liu H., Jiang H., Yan J., Gao G.F.
    J. Virol. 85:10319-10331(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-183.

Entry informationi

Entry nameiC8CIL7_9ENTO
AccessioniPrimary (citable) accession number: C8CIL7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: May 11, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.