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C8AE35 (C8AE35_STAAU) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein ArsC HAMAP MF_01624
Alternative name(s):
Arsenate reductase HAMAP MF_01624
Arsenical pump modifier HAMAP MF_01624
Low molecular weight protein-tyrosine-phosphatase HAMAP MF_01624
Gene names
Name:arsC HAMAP MF_01624
ORF Names:SACG_02580 EMBL EEV08356.1
OrganismStaphylococcus aureus subsp. aureus 68-397 EMBL EEV08356.1
Taxonomic identifier585146 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity. HAMAP MF_01624

Catalytic activity

Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O. HAMAP MF_01624

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. HAMAP MF_01624

Subunit structure

Monomer By similarity. HAMAP MF_01624

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family. HAMAP MF_01624

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site101Nucleophile; for reductase activity and phosphatase activity By similarity HAMAP MF_01624
Active site821Nucleophile; for reductase activity By similarity HAMAP MF_01624
Active site891Nucleophile; for reductase activity By similarity HAMAP MF_01624

Amino acid modifications

Disulfide bond10 ↔ 82Redox-active; alternate By similarity HAMAP MF_01624
Disulfide bond82 ↔ 89Redox-active; alternate By similarity HAMAP MF_01624

Sequences

Sequence LengthMass (Da)Tools
C8AE35 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 03871148DC433A18

FASTA13114,813
        10         20         30         40         50         60 
MDKKTIYFIC TGNSCRSQMA EGWGKEILGE GWNVYSAGIE THGVNPKAIE AMKEVDIDIS 

        70         80         90        100        110        120 
NHTSDLIDND ILKQSDLVVT LCSDADNNCP ILPPNVKKEH WGFDDPAGKE WSEFQRVRDE 

       130 
IKLAIEKFKL R

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		GG700590 Genomic DNA. Translation: EEV08356.1.

3D structure databases

ProteinModelPortalC8AE35.
SMRC8AE35. Positions 2-131.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC26223476. VBIStaAur3727_2704.

Family and domain databases

HAMAPMF_01624. Arsenate_reduct.
[Tree]
InterProIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. Low_mwt_PTPase. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. Tyr_Pase_low_mol_wt. 1 hit.
TIGRFAMsTIGR02691. ArsC_pI258_fam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC8AE35_STAAU
AccessionPrimary (citable) accession number: C8AE35
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: December 14, 2011
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info